Template talk:Estradiol metabolism
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Putting this here temporarily. Seppi333 (Insert 2¢) 21:05, 8 August 2018 (UTC)
Feedback
@Medgirl131: I've made the changes you indicated. If you have any other suggestions/feedback for the background image file, feel free to follow up via email and let me know; if you think it looks good now, I'll start annotating wikitext. Seppi333 (Insert 2¢) 19:23, 8 August 2018 (UTC)
- I went ahead and added the annotations since I'd still be using the same approximate coordinates for an annotation regardless of whether I end up swapping one compound with another. The enzyme labels still need to be added; a few minor tweaks the the enzyme annotation coordinates will probably be necessary once that's done. Seppi333 (Insert 2¢) 22:18, 8 August 2018 (UTC)
BRENDA ligand entries for Homo sapiens
17β-Estradiol → Estrone
- EC 1.1.1.35 - [1]
- EC 1.1.1.50 - [2]
- EC 1.1.1.51 - [3]
- EC 1.1.1.62 - [4]: indicates 17β-HSD2, 17β-HSD4, and 17β-HSD5 are involved in this reaction and 17β-HSD1 is the predominant mediator of the reverse reaction.
- EC 1.1.1.239 - [5]
- EC 1.1.1.357 - [6]
Estrone
- EC 1.1.1.62 - [7]: indicates 17β-HSD1 is the predominant mediator of Estrone → 17β-Estradiol.
- EC 1.1.1.239 - [8]
- EC 1.1.1.357 - [9]
Estrone sulfation:
- EC 2.8.2.2 [10]
- EC 2.8.2.4: "high activity by SULT1E1, low activity by phenol sulfotransferase SULT1A1, EC 2.8.2.1" (SULT1E1 = EST) - [11]
Estrone glucuronidation: