Template talk:Estradiol metabolism
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Feedback
@Medgirl131: I've made the changes you indicated. If you have any other suggestions/feedback for the background image file, feel free to follow up via email and let me know; if you think it looks good now, I'll start annotating wikitext. Seppi333 (Insert 2¢) 19:23, 8 August 2018 (UTC)
- I went ahead and added the annotations since I'd still be using the same approximate coordinates for an annotation regardless of whether I end up swapping one compound with another. The enzyme labels still need to be added; a few minor tweaks the the enzyme annotation coordinates will probably be necessary once that's done. Seppi333 (Insert 2¢) 22:18, 8 August 2018 (UTC)
BRENDA ligand entries for Homo sapiens
Listing what I find on catalyzing enzymes from a database search in this section. Seppi333 (Insert 2¢) 17:39, 10 August 2018 (UTC)
17β-Estradiol → Estrone
Comprehensive search with commentary on isoenzymes: [1]
- EC 1.1.1.35 - [2]
- EC 1.1.1.50 - [3]
- EC 1.1.1.51 - [4]
- EC 1.1.1.62 - [5]: indicates 17β-HSD2, 17β-HSD4, and 17β-HSD5 are involved in this reaction and 17β-HSD1 is the predominant mediator of the reverse reaction.
- EC 1.1.1.239 - [6]
- EC 1.1.1.357 - [7]
Estrone
Comprehensive search with commentary on isoenzymes: [8]
- EC 1.1.1.62 - [9]: indicates 17β-HSD1 is the predominant mediator of Estrone → 17β-Estradiol.
- EC 1.1.1.239 - [10]
- EC 1.1.1.357 - [11]
Estrone sulfation:
- EC 2.8.2.2 [12]
- EC 2.8.2.4: "high activity by SULT1E1, low activity by phenol sulfotransferase SULT1A1, EC 2.8.2.1" (SULT1E1 = EST) - [13]
Estrone glucuronidation:
Estrone 2-hydroxylation:
- Nothing listed – look for pathway in a textbook or review
Estrone 4-hydroxylation:
- Nothing listed – look for pathway in a textbook or review
Estrone 16α-hydroxylation:
- Nothing listed – look for pathway in a textbook or review
Estrone sulfate
Desulfation:
16α-Hydroxyestrone
→17-Epiestriol:
- Nothing listed – look for pathway in a textbook or review
→Estriol:
- Nothing listed – look for pathway in a textbook or review
→16-Epiestriol:
- Nothing listed – look for pathway in a textbook or review
Human Metabolome Database entries on ligands with enzymatic reactions listed
- 17β-HSD1 (listed as gene: HSD17B1) [Catalyzed reactions link: [17]]
- 17β-HSD2 (listed as gene: HSD17B2) [Catalyzed reactions link: [18]]
- 17β-HSD6 (listed as gene: HSD17B6) [Catalyzed reactions link: [19]]
- 17β-HSD7 (listed as gene: HSD17B7) [Catalyzed reactions link: [20]]
- 17β-HSD8 (listed as gene: HSD17B8) [Catalyzed reactions link: [21]]
- 17β-HSD11 (listed as gene: HSD17B11) [Catalyzed reactions link: [22]]
- 17β-HSD12 (listed as gene: HSD17B12) [Catalyzed reactions link: [23]]
CYP450:
- CYP1A1
- CYP1A2
- CYP1B1
- CYP2A7
- CYP2A13
- CYP2B6
- CYP2C8
- CYP2C9
- CYP2C19
- CYP2D6
- CYP2E1
- CYP2F1
- CYP2J2
- CYP2S1
- CYP3A4
- CYP4B1
- CYP4Z1
- CYP19A1C
... I think I'm just going to list "CYP450". Seppi333 (Insert 2¢) 18:32, 10 August 2018 (UTC)
- 16-Epiestriol - no enzymes listed
- 17-Epiestriol - no enzymes listed
- Estriol - metabolized into 16β-Hydroxyestrone by various 17β-HSD isoenzymes. No synthesizing enzymes listed.
- 2-Hydroxyestrone - COMT is listed as a metabolizing enzyme; no synthesizing enzymes listed.
- 4-Hydroxyestrone - no enzymes listed
- 16α-Hydroxyestrone - enzymes are listed but don't indicate reversibility (specifies estriol → 16α-Hydroxyestrone by four 17β-HSD isoenzymes).
- 16β-Hydroxyestrone - enzymes are listed, but as above, the specified reactions don't indicate reversibility (specifies estriol → 16β-Hydroxyestrone by six 17β-HSD isoenzymes, including the same four for 16α-Hydroxyestrone).
- BRENDA lists 16-hydroxysteroid epimerase as an enzyme the catalyzes the biotransformation of 16α-Hydroxyestrone into 16β-Hydroxyestrone (see this link for details).