OTC

OTC may refer to:

Science, medicine, and technology

Over-the-counter drug
On-tape Catalog, a section of a Microsoft Tape Format file
OpenType Collection (OTC), a file format for bundling multiple OpenType fonts
Orbiter test conductor, part of NASA's Launch Control Center
Ornithine transcarbamylase, also called OTC gene or ornithine carbamoyltransferase
Oxytetracycline

Oliver Typewriter Company, a former US company
One Thousand Children, child survivors of the Holocaust who fled to America without their parents
Open Text Corporation, a Canadian software company
Oriental Trading Company, based in Omaha, Nebraska
Oshkosh Truck Corporation, former name of the Oshkosh Corporation
OTC Tool Company, originally the Owatonna Tool Company
OTC Markets Group, a private company that provides services to the US over-the-counter securities market
Offshore Technology Conference, an organization that holds conferences on offshore energy technology, based in Houston, Texas

Oakwood Technology College, in Rotherham, South Yorkshire
Okefenokee Technical College, in Waycross and Alma, in the US state of Georgia
Ozarks Technical Community College, in Springfield, Missouri
Roy Campanella Occupational Training Center, public high school in Brooklyn, New York