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Mushroom poisoning

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See also: List of deadly fungi and List of poisonous fungi
Mushroom poisoning
SpecialtyEmergency medicine, mycotoxicology Edit this on Wikidata

Mushroom poisoning (also known as mycetism or mycetismus) refers to harmful effects from ingestion of toxic substances present in a mushroom. These symptoms can vary from slight gastrointestinal discomfort to death. The toxins present are secondary metabolites produced by the fungus. Mushroom poisoning is usually the result of ingestion of wild mushrooms after misidentification of a toxic mushroom as an edible species. The most common reason for this misidentification is close resemblance in terms of colour and general morphology of the toxic mushrooms species with edible species.

To prevent mushroom poisoning, mushroom gatherers familiarize themselves with the mushrooms they intend to collect as well as with any similar-looking toxic species. In addition, edibility of mushrooms may depend on methods of preparation for cooking. The edibility or toxicity of some species varies with geographic location.[citation needed]

Folk traditions

Many folk traditions concern the defining features of poisonous mushrooms.[1][2] However, there are no general identifiers for poisonous mushrooms, so such traditions are unreliable. Guidelines to identify particular mushrooms exist, and will serve only if one knows which mushrooms are toxic.

Examples of erroneous folklore "rules" include:

  • "Poisonous mushrooms are brightly colored." – Indeed, fly agaric, usually bright-red to orange or yellow, is narcotic and hallucinogenic, although no human deaths have been reported. The deadly destroying angel, in contrast, is an unremarkable white. The deadly Galerinas are brown. Some choice edible species (chanterelles, Amanita caesarea, Laetiporus sulphureus, etc.) are brightly colored, whereas most poisonous species are brown or white.
  • "Insects/animals will avoid toxic mushrooms." – Fungi that are harmless to invertebrates can still be toxic to humans; the death cap, for instance, is often infested by insect larvae.
  • "Poisonous mushrooms blacken silver." – None of the known mushroom toxins have a reaction with silver.
  • "Poisonous mushrooms taste bad." – People who have eaten the deadly Amanitas have reported that the mushrooms tasted quite good.
  • "All mushrooms are safe if cooked/parboiled/dried/pickled/etc." – While it is true that some otherwise-inedible species can be rendered safe by special preparation, many toxic species cannot be made toxin-free. Many fungal toxins are not particularly sensitive to heat and so are not broken down during cooking; in particular, α-amanitin, the poison produced by the death cap (Amanita phalloides) and others of the genus, is not denatured by heat.
  • "Poisonous mushrooms will turn rice red when boiled."[3] – A number of Laotian refugees were hospitalized after eating mushrooms (probably toxic Russula species) deemed safe by this folklore rule and this misconception cost at least one person her life.[4][5]
  • "Poisonous mushrooms have a pointed cap. Edible ones have a flat, rounded cap." – The shape of the mushroom cap does not correlate with presence or absence of mushroom toxins, so this is not a reliable method to distinguish between edible and poisonous species. Death cap, for instance, has a rounded cap when mature.
  • "Boletes are, in general, safe to eat." – It is true that, unlike a number of Amanita species in particular, in most parts of the world, there are no known deadly varieties of the genus Boletus, which reduces the risks associated with misidentification. However, mushrooms like the Devil's bolete are poisonous both raw and cooked and can lead to strong gastrointestinal symptoms, and other species like the lurid bolete require thorough cooking to break down toxins. As with other mushroom genera, proper caution is, therefore, advised in determining the correct species.

Causes

New species of fungi are continuing to be discovered, with an estimated number of 800 new species registered annually. This, added to the fact that many investigations have recently reclassified some species of mushrooms from edible to poisonous has made older classifications insufficient at describing what now is known about the different species of fungi that are harmful to humans. Thus, contrary to what older registers state, it is now thought that of the approximately 100,000 known fungi species found worldwide, about 100 of them are poisonous to humans.[6] However, by far the majority of mushroom poisonings are not fatal,[7] and the majority of fatal poisonings are attributable to the Amanita phalloides mushroom.[8]

Amanita spp., immature, possibly poisonous, Amanita mushrooms.
Edible shaggy mane Coprinus comatus mushrooms.

A majority of these cases are due to mistaken identity.[3] This is a common occurrence with A. phalloides in particular, due to its resemblance to the Asian paddy-straw mushroom, Volvariella volvacea. Both are light-colored and covered with a universal veil when young.

Amanitas can be mistaken for other species, as well, in particular when immature. On at least one occasion[9] they have been mistaken for Coprinus comatus. In this case, the victim had some limited experience in identifying mushrooms, but did not take the time to correctly identify these particular mushrooms until after he began to experience symptoms of mushroom poisoning.

Amanitas, two examples of immature Amanitas, one deadly and one edible.
Puffball, an edible puffball mushroom, which closely resembles the immature Amanitas.

The author of Mushrooms Demystified, David Arora[10] cautions puffball-hunters to beware of Amanita "eggs", which are Amanitas still entirely encased in their universal veil. Amanitas at this stage are difficult to distinguish from puffballs. Foragers are encouraged to always cut the fruiting bodies of suspected puffballs in half, as this will reveal the outline of a developing Amanita should it be present within the structure.

A majority of mushroom poisonings in general are the result of small children, especially toddlers in the "grazing" stage, ingesting mushrooms found in the lawn. While this can happen with any mushroom, Chlorophyllum molybdites is often implicated due to its preference for growing in lawns. C. molybdites causes severe gastrointestinal upset but is not considered deadly poisonous.

A few poisonings are the result of misidentification while attempting to collect hallucinogenic mushrooms for recreational use.[11] In 1981, one fatality and two hospitalizations occurred following consumption of Galerina autumnalis, mistaken for a Psilocybe species.[12] Galerina and Psilocybe species are both small, brown, and sticky, and can be found growing together. However, Galerina contains amatoxins, the same poison found in the deadly Amanita species. Another case reports kidney failure following ingestion of Cortinarius orellanus,[13] a mushroom containing orellanine.

It is natural that accidental ingestion of hallucinogenic species also occurs, but is rarely harmful when ingested in small quantities. Cases of serious toxicity have been reported in small children.[14] Amanita pantherina, while containing the same hallucinogens as Amanita muscaria (e.g., ibotenic acid and muscimol), has been more commonly associated with severe gastrointestinal upset than its better-known counterpart.[10]

Jack-O-Lantern, a poisonous mushroom sometimes mistaken for a chanterelle.
Chanterelle, edible.

Although usually not fatal, Omphalotus spp., "Jack-o-lantern mushrooms," are another cause of sometimes significant toxicity.[10] They are sometimes mistaken for chanterelles. Both are bright-orange and fruit at the same time of year, although Omphalotus grows on wood and has true gills rather than the veins of a Cantharellus. They contain toxins known as illudins, which causes gastrointestinal symptoms.

Bioluminescent species are generally inedible and often mildly toxic.[citation needed]

Clitocybe dealbata, which is occasionally mistaken for an oyster mushroom or other edible species contains muscarine.

Toxicities can also occur with collection of morels. Even true morels, if eaten raw, will cause gastrointestinal upset. Typically, morels are thoroughly cooked before eating. Verpa bohemica, although referred to as "thimble morels" or "early morels" by some, have caused toxic effects in some individuals.[15] Gyromitra spp., "false morels", are deadly poisonous if eaten raw. They contain a toxin called gyromitrin, which can cause neurotoxicity, gastrointestinal toxicity, and destruction of the blood cells.[16] The Finns consume Gyromitra esculenta after parboiling, but this may not render the mushroom entirely safe, resulting in its being called the "fugu of the Finnish cuisine".

A more unusual toxin is coprine, a disulfiram-like compound that is harmless unless ingested within a few days of ingesting alcohol. It inhibits aldehyde dehydrogenase, an enzyme required for breaking down alcohol. Thus, the symptoms of toxicity are similar to being hung over—flushing, headache, nausea, palpitations, and, in severe cases, trouble breathing. Coprinus species, including Coprinopsis atramentaria, contain coprine. Coprinus comatus does not,[17] but it is best to avoid mixing alcohol with other members of this genus.

Recently[when?], poisonings have also been associated with Amanita smithiana. These poisonings may be due to orellanine, but the onset of symptoms occurs in 4 to 11 hours, which is much quicker than the 3 to 20 days normally associated with orellanine.[18]

Paxillus involutus is also inedible when raw, but is eaten in Europe after pickling or parboiling. However, after the death of the German mycologist Dr Julius Schäffer, it was discovered that the mushroom contains a toxin that can stimulate the immune system to attack its own red blood cells. This reaction is rare, but can occur even after safely eating the mushroom for many years.[19] Similarly, Tricholoma equestre was widely considered edible and good, until it was connected with rare cases of rhabdomyolysis.[20]

In the fall of 2004, thirteen deaths were associated with consumption of Pleurocybella porrigens or "angel's wings".[21] In general, these mushrooms are considered edible. All the victims died of an acute brain disorder, and all had pre-existing kidney disease. The exact cause of the toxicity was not known at this time and the deaths cannot be definitively attributed to mushroom consumption.

However, mushroom poisoning is not always due to mistaken identity. For example, the highly toxic ergot Claviceps purpurea, which grows on rye, is sometimes ground up with rye, unnoticed, and later consumed. This can cause devastating, even fatal effects, which is called ergotism.

Cases of idiosyncratic or unusual reactions to fungi can also occur. Some are probably due to allergy, others to some other kind of sensitivity. It is not uncommon for an individual person to experience gastrointestinal upset associated with one particular mushroom species or genus.[21]

Toxins and their symptoms

See also: Category:Mycotoxins

Poisonous mushrooms contain a variety of different toxins that can differ markedly in toxicity. Symptoms of mushroom poisoning may vary from gastric upset to life-threatening organ failure resulting in death. Serious symptoms do not always occur immediately after eating, often not until the toxin attacks the kidney or liver, sometimes days or weeks later.

The most common consequence of mushroom poisoning is simply gastrointestinal upset. Most "poisonous" mushrooms contain gastrointestinal irritants that cause vomiting and diarrhea (sometimes requiring hospitalization), but usually no long-term damage. However, there are a number of recognized mushroom toxins with specific, and sometimes deadly, effects:

Toxin Toxicity Effects
Alpha-amanitin Deadly Causes often fatal liver damage 1–3 days after ingestion. Principal toxin in the death cap.
Phallotoxin Non-lethal Causes extreme gastrointestinal upset. Found in various mushrooms.
Orellanine Deadly Redox cycler similar to paraquat. Causes kidney failure within 3 weeks after ingestion. Principal toxin in genus Cortinarius.
Muscarine Potentially deadly Causes SLUDGE syndrome. Found in various mushrooms. Antidote is atropine
Monomethylhydrazine (MMH) Deadly Causes brain damage, seizures, gastrointestinal upset, and hemolysis. Metabolic poison. Principal toxin in genus Gyromitra. Antidote is large doses of intravenous pyridoxine hydrochloride[22]
Coprine Non-lethal Causes illness when consumed with alcohol. Principal toxin in genus Coprinus.
Ibotenic acid Potentially deadly Excitotoxin. Principal toxin in Amanita muscaria, A. pantherina, and A. gemmata.
Muscimol Psychoactive Causes CNS depression and hallucinations. Principal toxin in Amanita muscaria, A. pantherina, and A. gemmata.
Psilocybin and psilocin Psychoactive Causes CNS arousal and hallucinations. Principal Effects in psilocybin mushrooms, many of which belonging to the genus Psilocybe (often used recreationally).
Arabitol Non-lethal Causes diarrhea in some people.
Bolesatine Non-lethal Causes gastrointestinal irritation, vomiting, nausea.
Ergotamine Deadly Affects the vascular system and can lead to loss of limbs and/or cardiac arrest. Found in genus Claviceps.

The period of time between ingestion and the onset of symptoms varies dramatically between toxins, some taking days to show symptoms identifiable as mushroom poisoning.

  • Alpha-amanitin: For 6–12 hours, there are no symptoms. This is followed by a period of gastrointestinal upset (vomiting and profuse, watery diarrhea). This stage is caused primarily by the phallotoxins[23] and typically lasts 24 hours. At the end of this second stage is when severe liver damage begins. The damage may continue for another 2–3 days. Kidney damage can also occur. Some patients will require a liver transplant.[24] Amatoxins are found in some mushrooms in the genus Amanita, but are also found in some species of Galerina and Lepiota.[10] Overall, mortality is between 10 and 15 percent.[25] Recently, Silybum marianum or blessed milk thistle has been shown to protect the liver from amanita toxins and promote regrowth of damaged cells.[26][27]
  • Orellanine: This toxin causes no symptoms for 3–20 days after ingestion. Typically around day 11, the process of kidney failure begins,[23] and is usually symptomatic by day 20. These symptoms can include pain in the area of the kidneys, thirst, vomiting, headache, and fatigue. A few species in the very large genus Cortinarius contain this toxin. People having eaten mushrooms containing orellanine may experience early symptoms as well, because the mushrooms often contain other toxins in addition to orellanine.[28] A related toxin that causes similar symptoms but within 3–6 days has been isolated from Amanita smithiana and some other related toxic Amanitas.[29]
  • Muscarine: Muscarine stimulates the muscarinic receptors of the nerves and muscles. Symptoms include sweating, salivation, tears, blurred vision, palpitations, and, in high doses, respiratory failure.[30] Muscarine is found in mushrooms of the genus Omphalotus, notably the Jack o' Lantern mushrooms. It is also found in A. muscaria, although it is now known that the main effect of this mushroom is caused by ibotenic acid. Muscarine can also be found in some Inocybe species and Clitocybe species, in particular Clitocybe dealbata, and some red-pored Boletes.[10]
  • Gyromitrin: Stomach acids convert gyromitrin to monomethylhydrazine (MMH), a compound employed in rocket fuel. It affects multiple body systems. It blocks the important neurotransmitter GABA, leading to stupor, delirium, muscle cramps, loss of coordination,[23] tremors, and/or seizures. It causes severe gastrointestinal irritation, leading to vomiting and diarrhea. In some cases, liver failure has been reported.[23] It can also cause red blood cells to break down, leading to jaundice, kidney failure, and signs of anemia. It is found in mushrooms of the genus Gyromitra.[16] A gyromitrin-like compound has also been identified in mushrooms of the genus Verpa.[15] NOT CORRECT REFERENCE - IN REFERENCE 15 IS REPORTED "UNIDENTIFIED TOXIN" - NOT CLEAR...
  • Coprine: Coprine is metabolized to a chemical that resembles disulfiram. It inhibits aldehyde dehydrogenase (ALDH), which, in general, causes no harm, unless the person has alcohol in their bloodstream while ALDH is inhibited. This can happen if alcohol is ingested shortly before or up to a few days after eating the mushrooms. In that case the alcohol cannot be completely metabolized, and the person will experience flushed skin, vomiting, headache, dizziness, weakness, apprehension, confusion, palpitations, and sometimes trouble breathing. Coprine is found mainly in mushrooms of the genus Coprinus, although similar effects have been noted after ingestion of Clitocybe clavipes.
  • Ibotenic acid: Decarboxylates into muscimol upon ingestion. The effects of muscimol vary, but nausea and vomiting are common. Confusion, euphoria, or sleepiness are possible. Loss of muscular coordination, sweating, and chills are likely. Some people experience visual distortions, a feeling of strength, or delusions. Symptoms normally appear after 30 minutes to 2 hours and last for several hours. A. muscaria, the "Alice in Wonderland" mushroom, is known for the hallucinatory experiences caused by muscimol, but A. pantherina and A. gemmata also contain the same compound.[10] While normally self-limiting, fatalities have been associated with A. pantherina,[14] and consumption of a large number of any of these mushrooms is likely to be dangerous.
  • Psilocybin: Dephosphorylates into the psychoactive psilocin upon ingestion, which acts as a psychedelic drug. Symptoms begin shortly after ingestion. The effects can include euphoria, visual and religious hallucinations, and heightened perception. However, some persons experience fear, agitation, confusion, and schizophrenia-like symptoms. All symptoms generally pass after several hours. Some (though not all) members of the genus Psilocybe contain psilocybin, as do some Panaeolus, Copelandia, Conocybe, Gymnopilus, and others. Some of these mushrooms also contain baeocystin, which has effects similar to psilocin.
  • Arabitol: A sugar alcohol, similar to mannitol, which causes no harm in most people but causes gastrointestinal irritation in some. It is found in small amounts in oyster mushrooms, and considerable amounts in Suillus species and Hygrophoropsis aurantiaca (the "false chanterelle").[31]

Some mushrooms contain less toxic compounds and, therefore, are not severely poisonous. Poisonings by these mushrooms may respond well to treatment. However, certain types of mushrooms, such as the Amanitas, contain very potent toxins and are very poisonous; so even if symptoms are treated promptly mortality is high. With some toxins, death can occur in a week or a few days. Although a liver or kidney transplant may save some patients with complete organ failure, in many cases there are no organs available. Patients hospitalized and given aggressive support therapy almost immediately after ingestion of amanitin-containing mushrooms have a mortality rate of only 10%, whereas those admitted 60 or more hours after ingestion have a 50–90% mortality rate.[32]

Poisonous mushrooms

See also: List of deadly fungi and List of poisonous fungus species

Of the most lethal mushrooms, three—the death cap (A. phalloides), destroying angels (A. virosa and A. bisporigera), and the fool's mushroom (A. verna)—belong to the genus Amanita, and two more—the deadly webcap (C. rubellus), and the fool's webcap (C. orellanus)—are from the genus Cortinarius. Several species of Galerina, Lepiota, and Conocybe also contain lethal amounts of amatoxins. Deadly species are listed in the List of deadly fungi.

The following species may cause great discomfort, sometimes requiring hospitalization, but are not considered deadly.

Other causes

Rotten mushrooms may cause food poisoning. Mushrooms that are mushy, bad-smelling, or moldy (even of a choice edible species) may be toxic due to bacterial decay or mold. Also, mushrooms are sometimes contaminated by concentrating pollutants[citation needed].

Many mushrooms are high in chitinous fiber. Excessive consumption of mushrooms may lead to indigestion, which may be diagnosed as mushroom "poisoning".

It is plausible that some mushrooms might concentrate toxins from their growth substrate. For example, for this reason many sources recommend against eating Chicken of the Woods found growing on Yew[35], though this species is otherwise considered a choice and relatively safe edible.

Famous incidents

In fiction

  • In the civil war drama The Beguiled, Clint Eastwood's character John McBurney, an injured Union soldier at a boarding school for girls, was poisoned by a jealous, vengeful headmistress and her young female students. The headmistress was played by Geraldine Page.
  • In Bollywood movie 7 Khoon Maaf, Modhusudhon Tarafdar (Naseeruddin Shah), a Bengali doctor who rescues Susanna from a suicide attempt and marries her, tries to poison Susanna with mushroom soup several years later for her inheritance.
  • Linda Howard's action/romance novel Kiss Me While I Sleep has the anti-heroine use synthetic orellanine as a weapon.
  • In Julius Streicher's Nazi propaganda children's book The Poisonous Mushroom, Jews are compared to deadly fungi.
  • In "The Story of Babar" by Jean de Brunhoff, the King of the Elephants died from eating a poisonous mushroom.
  • The 1993 Italian film Fiorile features a woman who takes revenge on her brother by feeding him poisonous mushrooms.
  • In the 2017 film "The Phantom Thread", Alma fed poisonous mushrooms to the renowned fashion designer Reynolds Woodcock.

References

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  40. ^ Evans, N; Hamilton, A; Bello-Villalba, M. J; Bingham, C (2012). "Irreversible renal damage from accidental mushroom poisoning". BMJ. 345: e5262. doi:10.1136/bmj.e5262. PMID 22885396.
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