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This is an old revision of this page, as edited by 2a02:8070:27b9:8bf0:29cb:2f8a:e1e2:5f10 (talk) at 03:43, 13 January 2019 (→Off-label use for beard growth: new section). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

In need of depth

I second the prior call for additional information on its use as an antihypertensive. It's a third-line agent, but in refractory patients it is commonly considered. My particular interest is in knowing the incidence of pericardial effusions with minoxidil use. All the research appears to have been done in the late 70s and early 80s, and I'm having troubble accessing it. -- PCAndrew

"Cure" for hair loss?

Maybe someone asked this, but according to the line "known for its ability to slow or stop hair loss and promote hair regrowth" in the first paragraph, this implies a cure. So, is it? --IdLoveOne (talk) 05:22, 16 June 2008 (UTC)[reply]

Insofar as cessation of use of minoxidil will cause hair loss to resume, it's not a cure. Treatment has to be maintained permanently for the effects to be maintained. Martin Blank (talk) 19:42, 14 December 2008 (UTC)[reply]

hair growth

the current entry says that it is unknown how minoxidil stimulates hair growth, but i don't believe that is accurate. my understanding is that it dialates blood vessels, increasing blood flow to the area. (that's why it was originally thought of as a heart attack/blood pressure medicine, because it would dialate blood vessels, increasing blood flow)

yes and...it's exat mechanism of action is not...known.


ok, well we're kind of splitting hairs -- The article says "It is unknown how the drug stimulates hair growth." Known is that it stimulates hair growth by dialating blood vessels which increases blood flow to the area. What is unknown is exactly how it dialates blood vessels.

I think it's the other way round; it's known for its vasodilatory properties but it's unknown exactly how this vasodilation promotes hair growth. In fact, one could speculate that the promotion of hair growth could be as a result of a mechanism other than vasodilation (I have no scientific evidence for this - I'm just highlighting where the gap in the knowledge is). 78.144.78.170 (talk) 18:45, 9 June 2011 (UTC)[reply]

it opens atp sensitive k+ channels causing hyperpolarisation which opens ca2+ channels and this causes vasodilation and falling TPR

It apparently directly opens ATP sensitive potassium channels and it is not through the cGMP-PKG pathway as the article hints. The Potassium hypothesis is supported by other potassium channel agonist ( pinacidil) increasing hair growth, so the effect may not be vascular but directly on the dermal papillae. GetAgrippa 01:52, 6 January 2007 (UTC)[reply]

Also, it would be helpful if the article gave some indication of the drug's efficacy. What percentage of users experience hair growth, or cessation of hair loss?

Mechanism of hair loss treatment

Note that minoxidil's vasodilatory effect does not explain its ability to thicken hair. Other vasodilators have no effect on the hair.

Also - some in the hairloss community have started to use oral minoxidil tablets in an attempt to grow hair, although this is regarded as risky.

For citations, see for example: http://www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=39415&FTVAR_MSGDBTABLE=

Or search for "loniten" on any hairloss forum.

81.179.103.232 21:03, 29 July 2007 (UTC)[reply]

Loniten

This article really needs balance, as the drug was not originally for hair growth. 132.205.44.5 (talk) 02:30, 22 November 2007 (UTC)[reply]

I fully agree. This drug was -- and still is -- used for control of hypertension, and as such I prescribe it often in my work as a physician. Sadly this article barely talks about it. 59.125.23.30 (talk) 07:43, 8 May 2009 (UTC)[reply]
The following text is transcluded from Talk:Rogaine (drug) to Talk:Minoxidil primarily to show justification for merging those articles.

Propecia

Is there any information on the combination of using this and Propecia?

Plenty. In pubmed or google scholar you could find studies showing a synergistic effect when the two are used concurrently.

the link is not spam.

Wikipedia is not here to advertise your site. I will revert your edits if you keep spamming articles with the same link. --Tim1988 talk 10:37, 7 July 2006 (UTC)[reply]
Im not spamming the article, you idiot. The website isn't selling anything, its a related link to the topics.
Don't behave like a child.

Propose merging into Minoxidil article

Since Rogaine and Regaine are really nothing more than brand names for Minoxidil, I propose merging this article into the Minoxidil article. I suggest that Rogaine (drug) and Regaine should then redirect to the Minoxidil article. --JHP 07:11, 24 July 2007 (UTC)[reply]

Merge completed - Draeco (talk) 03:49, 4 March 2008 (UTC)[reply]

End of transcluded text.

Reference No. 6 contains a dead URL

Currently links to "http://www.showcatsonline.com/x/minoxidil.htm" (404)

Should link to "http://www.showcatsonline.com/x/minoxidil.shtml"

Alsavage (talk) 20:26, 23 August 2008 (UTC)[reply]

 Fixed, thank you. Fvasconcellos (t·c) 20:35, 23 August 2008 (UTC)[reply]

Feline toxicity

Just HOW toxic to cats is it? Obviously, you can't exactly go around spraying them with it... But is playing with or sharing a pillow with a minoxidil user dangerous to cats??? —Preceding unsigned comment added by Aadieu (talk • contribs) 20:03, 17 March 2010 (UTC)[reply]

I've used it for about two years and my cat seems okay. The toxicity was discovered because ridiculous people actually used it ON show cats. Cats cannot metabolize minoxidil and it kills them, and I think the amount needed to become toxic is still unknown; on the other hand I think we would be able to turn up more information on the subject if it were EASY to kill cats with minoxidil accidentally.--98.216.50.36 (talk) 05:27, 28 April 2011 (UTC)[reply]

Does Minoxidil has anything to do with Amenixil? It's referenced on de: Cogiati (talk) 22:11, 21 April 2010 (UTC)[reply]

commercial

Isn't the picture of the regain a commercial, they invented the medicine but they are not the only producer.And this picture contribute anything to the article? —Preceding unsigned comment added by 94.159.211.57 (talk) 19:24, 31 October 2010 (UTC)[reply]

Collagen Depletion and effects on face of the topical Minoxidil

Are there any studies that cover this topic? The link goes to a study which proves that minoxidil depletes collagen when applied in vitro for subconjunctival fibroblasts of Rabbits. Are there any studies regarding topical application and the documentation of this side effect? Scientifically I'm interested and personally I'm concerned :)


Dose0017 (talk) 17:23, 3 February 2014 (UTC)[reply]

Guinter Kahn

I am surprised this article makes no mention of one of this drug's inventors, Guinter Kahn. See this New York Times article. Best.4meter4 (talk) 16:49, 20 September 2014 (UTC)[reply]

hair loss

81.135.37.186 you keep wanting to add content about hair loss but I have not found that in any source. You cited http://www.drugs.com/pro/minoxidil.html - would you please quote the part of that article where exacerbated hair loss is discussed? Please discuss. Thanks. Jytdog (talk) 14:37, 19 January 2015 (UTC)[reply]

I've requested semi-protection. Jytdog (talk) 18:32, 19 January 2015 (UTC)[reply]
Jytdog, the first reference was indeed wrong, earlier today. I have instead inserted the correct reference for hair loss - just search the reference http://www.drugs.com/sfx/rogaine-side-effects.html for "exacerbate", you will find it easily. A Chemist--81.131.172.95 (talk) 18:42, 19 January 2015 (UTC)[reply]
you are an edit-warring ass. terrible behavior. Thank you for finally talking and for providing a real source. Jytdog (talk) 18:48, 19 January 2015 (UTC)[reply]
I made one (!) mistake. That does not deserve your foul language. And a good evening to you, too. — Preceding unsigned comment added by 81.131.172.95 (talk) 18:51, 19 January 2015 (UTC)[reply]


Side effects?

I don't see any discussion of side effects. I have yet to see *any* drug whichis actually effective which has *no* side effects, and the absence makes it look like nothing more than an ad. Critterkeeper (talk) 05:25, 1 February 2016 (UTC)[reply]

Minoxidil#Side_effects.... ? Jytdog (talk) 06:21, 1 February 2016 (UTC)[reply]

Off-label use for beard growth

The internet is full of attempts and reports about applying Minoxidil to trigger or improve beard growth in adult men. I myself have used it successfully that way. Would be interesting to find a source and add this. 2A02:8070:27B9:8BF0:29CB:2F8A:E1E2:5F10 (talk) 03:43, 13 January 2019 (UTC)[reply]

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