Kisspeptin

Kisspeptin the product of the gene Kiss1 is a G-protein coupled receptor ligand for GPR54. Kiss1 was originally identified as a human metastasis suppressor gene that has the ability to suppress melanoma and breast cancer metastasis. It is recently become clear that kisspeptin-GPR54 signalling has an important role in initiating GnRH secretion at puberty, the extent of which is an area of ongoing research.