PRMT2

PRMT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X2P
Identifiers
Aliases	PRMT2, HRMT1L1, protein arginine methyltransferase 2
External IDs	OMIM: 601961; MGI: 1316652; HomoloGene: 55587; GeneCards: PRMT2; OMA:PRMT2 - orthologs
EC number	2.1.1.321
Gene location (Human)
Chr.	Chromosome 21 (human)
End	46,665,124 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	76,073,699 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right coronary artery; ; ganglionic eminence; ; tibial nerve; ; popliteal artery; ; tibial arteries; ; granulocyte; ; thoracic aorta; ; ascending aorta; ; ventricular zone;
	Top expressed in
	Hypothalamus; ; neural tube; ; Mesencephalon; ; rhombencephalon; ; dentate gyrus of hippocampal formation granule cell; ; ganglionic eminence; ; hippocampus proper; ; placenta; ; olfactory bulb; ; lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; histone methyltransferase activity; protein homodimerization activity; progesterone receptor binding; transcription coactivator activity; signal transducer activity; thyroid hormone receptor binding; protein binding; androgen receptor binding; peroxisome proliferator activated receptor binding; retinoic acid receptor binding; estrogen receptor binding; protein-arginine N-methyltransferase activity; histone-arginine N-methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; Rb-E2F complex; nucleoplasm; nucleolus; nucleus;
Biological process	developmental cell growth; negative regulation of G1/S transition of mitotic cell cycle; positive regulation of transcription, DNA-templated; methylation; positive regulation of apoptotic process; regulation of androgen receptor signaling pathway; histone methylation; negative regulation of transcription, DNA-templated; negative regulation of NF-kappaB transcription factor activity; signal transduction; protein methylation; histone arginine methylation; peptidyl-arginine N-methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	3275
	15468
	ENSG00000160310
	ENSMUSG00000020230
	P55345
	Q9R144
NM_001242864; NM_001242865; NM_001242866; NM_001286676; NM_001286677;
	NM_001286678; NM_001535; NM_206962
	NM_001077638; NM_133182; NM_001302965
NP_001229793; NP_001229794; NP_001229795; NP_001273605; NP_001273606;
	NP_001273607; NP_001526; NP_996845
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protein arginine N-methyltransferase 2 is an enzyme that in humans is encoded by the PRMT2 gene.^[5]^[6]

Template:PBB Summary

Interactions

PRMT2 has been shown to interact with Estrogen receptor alpha^[7] and HNRPUL1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160310 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020230 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF (Jun 1998). "Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)". Genomics. 48 (3): 330–40. doi:10.1006/geno.1997.5190. PMID 9545638.
^ "Entrez Gene: PRMT2 protein arginine methyltransferase 2".
^ Qi, Chao; Chang Jeffrey; Zhu Yiwei; Yeldandi Anjana V; Rao Sambasiva M; Zhu Yi-Jun (Aug 2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. 277 (32). United States: 28624–30. doi:10.1074/jbc.M201053200. ISSN 0021-9258. PMID 12039952. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Kzhyshkowska, J; Schütt H; Liss M; Kremmer E; Stauber R; Wolf H; Dobner T (Sep 2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. 358 (Pt 2). England: 305–14. doi:10.1042/0264-6021:3580305. ISSN 0264-6021. PMC 1222062. PMID 11513728. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading