Talk:Vitamin K

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Too much vitamin k ?

This is not really a problem. Vitamin K is a cofactor - excess levels do not increase thrombosis risk as such. Only too little (such as in malabsorption of breastfeeding babies) may lead to a coagulopathy. JFW | T@lk 07:53, 5 Nov 2004 (UTC)

Someone who understands the issues might want to add something on the issue of interferance with warfarin . See issues with Anlene milk powder[1]

Better link[2]. This is completely reasonable, although I think using vitamin K for bone health is unproven bunk. JFW | T@lk 14:55, 4 August 2006 (UTC)

Why? Lots of recent clinical data support it. Vitamin K, and particularly K2, seems to move calcium into the bones. 1,25D3 only moves it into the bloodstream. K2 helps with both CHD and osteoporosis. It exerts certain effects that K1 does not in this area, and is not inhibited by salicylates. --Ryan Wise (talk) 22:22, 3 May 2009 (UTC)

Pubmed search. JFW | T@lk 14:57, 4 August 2006 (UTC)

Don't have the journal references handy, but I ran into one article which did a trial of *K1* supplementation and did not find a correlation with bone density. But another (more recent) article found was a trial of K2 supplementation did affect bone density. There is also an association found between bone density and/or osteoporosis rates (forget which), and vitamin K level, although which way that correlation goes, and why, wasn't clear to the researchers as I recall from the article. It's been a while since I looked into the vitamin K lit (pulling up stuff for autism research..)

As a patient taking Marcomar (the Swiss equivalent of Warfarin), I suggest being careful about advice in this area. All the doctors I have seen have stressed to NOT CHANGE YOUR NORMAL DIET. They did suggest that eating a large amount (plate full) of cabbage or brussel sprouts wouldn't be clever, but, eating these high % foods shouldn't be a problem in 'normal' portions. The reason for this seems to be the fact that these Anticoagulant drugs act very slowly meaning it is really difficult to establish the correct dose. If you couple the dosage issue with a situation where the patient also changes diet in a significant way, then you have a danger that the blood thins too much or more than expected leading to a danager of bleeding and haemorages. Therefore, my doctors are saying don't change your diet, adjust the drug dose to fit with your normal eating habits. —Preceding unsigned comment added by 128.246.4.6 (talk) 09:41, 15 February 2008 (UTC)

You may want to read this article in regards to k2 and warfarin. [3] Of note, it's slowly emerging that since salicylates work by inhibiting K1 that they actually lead to more heart attacks down the line. --Ryan Wise (talk) 22:21, 3 May 2009 (UTC)—Preceding unsigned comment added by Wiserd911 (talk • contribs) 22:19, 3 May 2009

Agree. Olbenberg notes this too in his article on vitamin K notes that a small supplemtary dose of vitamin K seems to stabilize the K cycle against disruptions caused by mutations which affect warfarin activity.

Why "K"

All the othervitamins go in alphabetical order: A, B, C, D, E, why "Vitamin K"? Why not vitamin F? --Munchkinguy 19:00, 2 Jun 2005 (UTC)

Because the scientist who discovered this antihaemorrhagic vitamin in 1935 was Danish, and called it Koagulation (coagulation) vitamin. JFW | T@lk 22:40, 2 Jun 2005 (UTC)

Also the naming of different B vitamins and other substances had originally been named F,G,H,I e.t.c when they were first discovered but through the years they either adopted another name or have been removed from the vitamin group in general so there are empty positions, the same holds true for "missing" numbers in the B complex. 89.133.150.230 (talk) 20:44, 7 March 2008 (UTC)

Dangers?

Italic text Hey. =) —Preceding unsigned comment added by 83.70.75.7 (talk) 16:34, 16 January 2010 (UTC)

With oral vit. K doses available as a safer alternative, and knowing the risks of injections (contaminants, autoimmune diseases, anaphilaxis, nerve injury, etc.) I totally don’t understand this injection craze. It must be a iatrogenic strategy to ensure a constant flow of patients in the future. — Preceding unsigned comment added by 145.64.134.245 (talk) 15:29, 4 February 2014 (UTC)

Physiology of vitamin K

This free article outlines the pleiotropic roles of vitamin K. Worth including. JFW | T@lk 21:22, 6 September 2006 (UTC)

Now it's used once in Physiology (ref name=Berkner) but probably deserves more use, eg. re VKD proteins & atherosclerosis specifically. Rod57 (talk) 10:48, 1 July 2010 (UTC)

Slang

I've taken the liberty of revamping the slang section about "vitamin K" as slang for ketamine; the term is in common use and important. The old version stated that ketamine was Schedule I. This is bunk and smacks of poor research at best and fearmongering at worst. I've also decided to remove the term "powerful"-- ketamine may or many not be powerful (whatever a "powerful" drug is), but its potency and efficacy are better addressed in the ketamine article and its references. I also explicitly referred to it as a dissociative anesthetic and linked it as such.

I think the slang section is about as long as it ever needs to be (unless new important usages pop up), since this article should really be about napthoquinones. Is this section a good solution, or should there be a disambiguation page? Kajerm 04:56, 3 November 2006 (UTC)

Are Vitamin K and ketamine the same thing?

Are vitamin K and ketamine the same thing? I have looked on websites and they tell me they are different however other websites say they are the same. Which is true? —The preceding unsigned comment was added by 88.110.252.29 (talk) 10:39, 10 March 2007 (UTC).

No. This question is addressed in the article at the top in the comment about disambiguation with ketamine. --EricE 18:38, 22 May 2007 (UTC)

Pictures are inconsistent

The ball and stick pictures do not currently match their respective molecular diagrams. For starters, the diagrams show oxygens double-bonded to carbon, outside the ring. The ball and stick figures show the oxygen as being part of the ring. —Preceding unsigned comment added by 72.227.129.47 (talk) 06:23, 23 January 2008 (UTC)

Origin of "Vitamin K"

Vitamin K is named K for the Danish, not German, word koagulation (coagulation). This is mentioned in all the biochemistry books (hereunder Stryer: Bochemistry, Voet&Voet, Biochemistry), that deals with vitamin K. Moreover, I am Danish, as the discoverer of vitamin K is, and has heard the story from my biochemistry teachers at different lectures at the university (University of Southern Denmark). Therefore, please do not change the origin of the word back to German again. it is simply not true!

PernilleGodiva —Preceding unsigned comment added by PernilleGodiva (talk • contribs) 11:44, 4 February 2008 (UTC)

According to the article: "The new vitamin received the letter K because the initial discoveries were reported in a German journal, in which it was designated as Koagulationsvitamin."

Do you disagree with this statement? --Slashme (talk) 14:28, 4 February 2008 (UTC)

Another reference is Brody, Tom (1999). Nutritional biochemistry. Boston: Academic Press. ISBN 0-12-134836-9. which says it's from German --Slashme (talk) 14:49, 4 February 2008 (UTC)

And also the Merck Index of Chemicals and Drugs, citing some references:

The designation K is derived from the German "Koagulationsvitamin": Dam, Biochem. Z. 215, 475 (1929); 220, 158 (1930); Nature 135, 652 (1935).

--Slashme (talk) 14:53, 4 February 2008 (UTC)

Fine with me :-)PernilleGodiva (talk) 09:50, 5 February 2008 (UTC)

I will give you, that he published in a German paper. But the vitamin has not been named in German, it just fits snuggly with the spelling being alike on both languages! Therefore, the naming was made in Danish (please look at the alikeness of the words), but published in German, and therefore for the sake of being readable written like that.

It may be that the name was conceived in Danish, but we have to work with published sources. --Slashme (talk) 05:52, 5 February 2008 (UTC)

OK, here's one from the horse's mouth, so to speak. "It is proposed to term this factor vitamin K (Koagulations-Vitamin in German and the Scandinavian languages)." from CLIV. THE ANTIHAEMORRHAGIC VITAMIN OF THE CHICK. BY HENRIK DAM. From the Biochemical Institute, University of Copenhagen. (Received April 8th, 1935.) so maybe we should indeed change the text to read "German and Danish"? --Slashme (talk) 06:00, 5 February 2008 (UTC)

I've been trying to verify the first use of Koagulations-Vitamin, but can't find those 1929 and 1930 references from Biochem Z. Does anybody have a copy? I think the article is wrong with the 1929 date: the lack of a vitamin was discovered in 1929, but the actual identity of the missing component wasn't nailed until 1935. But I can't confirm or refute this until I see those two papers ... Cloning jedi (talk) 14:04, 8 February 2013 (UTC)

Here's a followup. As far as I can tell, "Vitamin K" wasn't coined until 1935. And it wasn't published in a German journal:

"In 1934, after much experimentation with the addition of vitamin C and other known vitamins, he concluded that a hitherto unknown factor was essential for the coagulation of blood. He called this substance “vitamin K” (from the first letter of the Danish and German word (coagulation), thus symbolizing its ability to coagulate blood and to prevent hemorrhage. Within a year after this discovery, Doisy elucidated the chemical nature of vitamin K." -from http://www.mayoclinicproceedings.org/article/S0025-6196(11)63617-3/fulltext

"Vitamin K" is first mentioned in 1935: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266625/ . Dam did not use the term in his 1934 Biochem J paper, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253344/, which implies he hadn't thought of the word yet. What he discovered in 1929 was that something was missing; but what this was didn't become clear for another 5 or 6 years. Unless somebody can show me those Biochem Z papers then I will edit the article accordingly. The quote from the Merck Index ('The designation K is derived from the German "Koagulationsvitamin": Dam, Biochem. Z. 215, 475 (1929); 220, 158 (1930); Nature 135, 652 (1935).'), isn't sufficient by itself, as it's not clear exactly what the citation is supporting (and people do make mistakes in citations). Dam claims it was from "Scandinavian and German", in 1935, in his Nobel Lecture: http://www.nobelprize.org/nobel_prizes/medicine/laureates/1943/dam-lecture.html. The 1999 Brody reference asserts it's from German, without a supporting citation, by the way. Cloning jedi (talk) 11:48, 11 February 2013 (UTC)

PernilleGodiva implies Coagulation is the German word for coagulation. It isn't. It begins with a K, Koagulation. The Danish is perhaps the same spelling as the German. Or the German is the same spelling as the Danish. Possibly a touch of Germanophobia here.Fletcherbrian (talk) 16:41, 22 May 2014 (UTC)

Sources (of vitamin K)

Just chicken egg yolks? Really? That seems unusually specific. Do we mean all bird eggs or really just chickens? 172.142.84.245 (talk) 04:39, 9 February 2008 (UTC)

I see bananas in the list of main sources, but at 0.5 micrograms per 100 grams, I dispute whether bananas can really be considered a true 'main source' of Vitamin K. I suspect there is a confusion here between the Vitamin K and the mineral Potassium (Chemical symbol K). As a non expert, I have not edited out bananas, but, at least added a link to the banana page that was missing that shows that Vitamin K is not listed as a significant nutrient within the fruit. —Preceding unsigned comment added by 128.246.4.6 (talk) 09:33, 15 February 2008 (UTC)

Please can we get rid of the '1/2 a cup' rubbish, I would do it but I don't feel qualified given that the 'cup' measurement is different depending on what is being measured - totally asinine. Measurements by weight please, not based on some idiotic method which results in different amounts every time something is apportioned.

How much is a cup? Is this referring to a:

1) Metric Cup 2) US customary Cup 3) US legal Cup, 4) An Imperial Cup, 5) A Japanese Cup 6) A traditional Japanese Customary cup.

Or is it referring to weight, see here: https://en.wikipedia.org/wiki/Cup_%28unit%29#Using_volume_measures_to_estimate_mass — Preceding unsigned comment added by 95.141.18.189 (talk) 12:30, 7 October 2013 (UTC)

It just an approximate amount, even using an exact mass of the foodstuff would presumably give only a certain degree of accuracy to the figures which will vary. To be honest the real problem is giving vague approximations then having 3 significant figures in the amounts of the vitamins. It implies a level of precision that simply isnt justified. But whatever, people who want to know how much K is in brocolli or want to compare food A with food B can get the info they are looking for. 78.55.151.47 (talk) 17:27, 3 April 2016 (UTC)

topical vitamin k

may be worth having a section in the article on topical use of vitamin k —Preceding unsigned comment added by EBMdoc (talk • contribs) 14:31, 9 February 2008 (UTC) Green leafy vegetables e.g. spinach, swiss chard, lettuce. —Preceding unsigned comment added by 83.70.75.7 (talk) 16:36, 16 January 2010 (UTC)

Clarity please? "dark circles"

What on earth are dark circles??! Please elaborate?Jkjambsj (talk) 17:21, 10 March 2009 (UTC) "Fifty-seven adults with dark circles participated in this 8-week study" being, 57 members of the freemasons, the illuminati, the Vatican and similar dark circles.Jkjambsj (talk) 17:25, 10 March 2009 (UTC)

NPOV Question: Vitamin K as a Beauty Product

In the Vitamin K as a Beauty Product section, the results of the study referenced are described "the results, while not a slam-dunk, weren't exactly discouraging either". This seems to be breaking NPOV and offers no concrete information as to what the results of the study really were. 24.185.71.65 (talk) 14:02, 14 March 2009 (UTC)

You're right; I've removed that phrase. Mindmatrix 15:41, 14 March 2009 (UTC)

Vitamin K as a Beauty Product

I have added the importance-sect tag to "Vitamin K as a Beauty Product". Considering one study with ambiguous results, I do not feel this worthy of inclusion. Notably, considering the psychological aspects of testing, the current text do not imply anything interesting. (That this applies to the source too, is obviously not guaranteed.) 88.77.151.79 (talk) 09:47, 18 June 2009 (UTC)

needs section re vitamin-D toxicity or inappropriate vascular mineralization

emerging area but reasonably notable by now- calcification in cvd or ckd hgas only recntly been noted to be of clinical rtelevance. Krueger, T; Ketteler, M; Schurgers, LJ; Floege, J (Jul-2009). "Vitamin K deficiency in CKD patients: a modifiable risk factor for vascular calcification?". Kidney international. 76 (1): 18–22. doi:10.1038/ki.2009.126. PMC 10.1038/ki.2009.126. PMID 19387474. {{cite journal}}: Check |pmc= value (help); Check date values in: |date= (help)CS1 maint: date and year (link)

Krueger, T; Schurgers, L; Brandenburg, V (Feb-2009). "Coagulation meets calcification: the vitamin K system". The International journal of artificial organs. 32 (2): 67–74. PMID 19363777. {{cite journal}}: Check date values in: |date= (help)CS1 maint: date and year (link)

Spasovski, GB (2007). "Bone health and vascular calcification relationships in chronic kidney disease". International urology and nephrology. 39 (4): 1209–16. doi:10.1007/s11255-007-9276-9. PMC 10.1007/s11255-007-9276-9. PMID 17899431. {{cite journal}}: Check |pmc= value (help)CS1 maint: date and year (link)

Hruska, KA; Mathew, S; Lund, R. "Renal osteodystrophy, phosphate homeostasis, and vascular calcification". Seminars in dialysis. 20 (4): 309–15. doi:10.1111/j.1525-139X.2007.00300.x. PMC 10.1111/j.1525-139X.2007.00300.x. PMID 17635820. {{cite journal}}: Check |pmc= value (help)

Proudfoot, D (Oct-2006). "Molecular mechanisms mediating vascular calcification: role of matrix Gla protein". Nephrology (Carlton, Vic.). 11 (5): 455–61. doi:10.1111/j.1440-1797.2006.00660.x. PMC 10.1111/j.1440-1797.2006.00660.x. PMID 17014561. {{cite journal}}: Check |pmc= value (help); Check date values in: |date= (help)CS1 maint: date and year (link)

Younes, NA; Mahafzah, W; Ailabouni, W; Al-Mansour, M; Hamzah, Y; Sroujieh, AS (May-2006). "The spectrum of bone disease in Jordanian hemodialysis patients". Saudi medical journal. 27 (5): 667–71. PMID 16680258. {{cite journal}}: Check date values in: |date= (help)CS1 maint: date and year (link)

de Francisco, AL (Dec-2004). "Secondary hyperparathyroidism: review of the disease and its treatment". Clinical therapeutics. 26 (12): 1976–93. doi:10.1016/j.clinthera.2004.12.011. PMC 10.1016/j.clinthera.2004.12.011. PMID 15823762. {{cite journal}}: Check |pmc= value (help); Check date values in: |date= (help)CS1 maint: date and year (link)

Okada, N (May-2004). "[K/DOQI clinical practice guidelines for management of renal osteodystrophy in predialysis patients]". Clinical calcium. 14 (5): 698–706. PMID 15577030. {{cite journal}}: Check date values in: |date= (help)CS1 maint: date and year (link)

Nerdseeksblonde (talk) 15:36, 10 November 2009 (UTC)

K2 deficiency

"Vitamin K2 (menaquinone, menatetrenone) is normally produced by bacteria in the large intestine,[2] and dietary deficiency is extremely rare unless the intestines are heavily damaged, are unable to absorb the molecule, or are subject to decreased production by normal flora, as seen in broad spectrum antibiotic use[3]."

This is ungrounded information. I checked both sources (2) and (3) and there are no such conclusions there. Please add relevant publication backing this claim.

--79.186.82.165 (talk) 13:16, 30 March 2010 (UTC)

I agree there is little evidence to support intestinal flora as source of vitamin K in humans and even less so in breastfeeding infants who's flora will digsest vitamin k but doesn't produce K this was originally noted by H Dam, and is in some other subsequent studies. There is evidence that from vitamin k 1 it is converted in the body to K2 , radioactive labeled material eaten. This whole subject experienced an explosion of research about 10 or so years ago, having to with preventing or dealing with diseases of the aging baby boomers. —Preceding unsigned comment added by 24.255.26.122 (talk) 08:13, 28 December 2010 (UTC)

Do we need both K1 and K2

Article does not clarify if we need both K1 and K2 or any of K3, K4, K5. The EPIC-Heidelburg study suggests that K1 does not fully substitute for K2. Many places in the article just refer to vitamin K without clarifying if they mean K1 or K2 or some typical mixture of the two. Rod57 (talk) 19:14, 6 April 2010 (UTC)

New study on tranexamic acid

I recently saw a headline that an antifibrolytic agent, tranexamic acid, was found to be a life-saving intervention against bleeding and death from accidents.[4][5] Though perhaps the research hasn't yet been done, I thought I should just toss out the question of whether vitamin K injection has been tested for trauma in non-deficient people other than childbirth or osteoporotic bone fracture. Is vitamin K a non-prescription alternative to tranexamic acid for purposes of first aid?

The Lancet article doesn't discuss vitamin K, but to me something seems very suspicious. A traumatic accident should be the acid test in the evolution of clotting. If an injection of a drug to fool with the regulation of clotting at the last moment could save tens of thousands of lives, doesn't that imply that the general population is a little short on some natural nutrient, perhaps that of vitamin K? Wnt (talk) 17:38, 15 June 2010 (UTC)

Is this accurate?

"Treatment usually consists of repeated intravenous doses of vitamin K, followed by doses in pill form for a period of at least two weeks, though possibly up to 2 months, afterwards (in the case of the more potent 4-hydoxycoumarins used as rodenticides). If caught early, prognosis is good, even when great amounts of the drug or poison are ingested."

Really? I don't know anything about human medicine, but in animals (pets that accidentally ingest rodenticides) we might give one subcutaneous injection of Vit K1 and then oral therapy for however long is needed based on the exact rodenticide. I've never heard of Vit K1 being administered IV??? In fact, I have heard of adverse reactions occuring from a SQ injection....let alone an IV injection. Can anyone clarify this point? —Preceding unsigned comment added by 70.27.100.172 (talk) 11:23, 20 October 2010 (UTC) Vitamin K injections can be used to stop internal bleeding on dogs. Followed by Vitamin K pills. Main use is if dog is suffering from symptoms of ingesting certain type of rat poison that kills rats with an anticogluent. Symptoms in dog will be lethargic, spotted gums and pale tongue. Source: is self from veterinary clinic in Willmar Minnesota. — Preceding unsigned comment added by 142.197.50.143 (talk) 20:35, 14 April 2018 (UTC)

Article treatment of MK4 vs MK7

While the article does note that MK7 is helpful with arterial calcification, there are a number of places in the article where MK4 is noted as having beneficial effects, as if to the exclusion of other forms of K2 such as MK7. I realize that there are more citations in the literature regarding MK4 but should this be corrected? It seems like both MK4 and MK7 have beneficial effects (though different dosages of each are tolerated) and this isn't uniformly presented in the article. Also, there are some suggestions that K2 improves bone strength disproportionate to improvements in bone mineral density. While many drugs have better efficacy in promoting BMD K2 is comparable-or-superior in terms of preventing fractures relative to many drugs. I don't have authoritative cites for this on hand, but given that structure and not just density is a significant factor, perhaps something along these lines is worth noting? --Ryan W (talk) 04:03, 26 September 2011 (UTC)

European J. of Nutrition quote

Guidance level for upper safe intake of vitamin K. Vitamin K is a lipid soluble vitamin. The current consideration of a tolerable upper level for vitamin K is focused on phylloquinone, the predominant dietary source. The SCF concludes in their opinion on vitamin K that, in the limited numbers of human studies,‘there is no evidence of adverse effects associated with supplementary intakes of vitamin K in the form of phylloquinone of up to 10 mg/day (more than two orders of magnitude higher than the recommended dietary intake of vitamin K) for limited periods of time.’ The SCF is, therefore,not able to establish a UL for vitamin K intake.The same conclusion was reached by the US IOM and by the EVM [5, 21]. The EVM has,however, established a GL for safe upper intake by applying an uncertainty factor of 10 to the dose of 10 mg/day that has been investigated in a small number of subjects (n=8) [40] resulting in a GL of 1 mg/day that is unlikely to result in adverse effects [21].We suggest using this GL until further knowledge on potential adverse effects of vitamin K is gathered.We also suggest differentiating this GL to other age groups on a bw0.75 basis(see Table 2).

---some jerk on the Internet (talk) 16:02, 15 December 2011 (UTC)

Clarification Vit K1/K2/K3

I am not clear about the role of Vit K 2 in coagulation. Antibiotic use can prolong PT time. I think a table would be useful: Source, role confirmed/suspected, influenced by. Right now it's a pretty chemical article, but the practical implication are vast. Thanks, keep up the good work. Flori122 (talk) 21:57, 31 January 2012 (UTC)

Inconsistent information about deficiency.

The article says under Vitamin K absorption and dietary need that deficiency was thought to be uncommon, then found to be common. Later, it says under Deficiency that deficiency is uncommon. 63.192.133.72 (talk) 01:42, 6 April 2012 (UTC)

Vitamin K2 and Heart Disease

The Rotterdam Study is cited (39 : http://www.ncbi.nlm.nih.gov/pubmed/15514282) but only in the context of Vitamin K absorption. While arterial calcification is mentioned here and there in the article, I think there are grounds for a section titled "Vitamin K2 and Heart Disease" citing the Rotterdam Study, amongst others (eg http://www.ncbi.nlm.nih.gov/pubmed/19179058). — Preceding unsigned comment added by 174.25.99.162 (talk) 05:49, 3 July 2012 (UTC)

I added an older reference that explicitly mentions (in the abstract) aortic calcification. Whether this justifies creating a new section heading, I don't know. Greensburger (talk) 05:48, 5 July 2012 (UTC)

No interference with or interaction with dabigatran etexilate / Pradaxa:

No interference with or interaction with Pradaxa:

"Research into the antioxidant properties of vitamin K indicates that the concentration of vitamin K is lower in the circulation of carriers of the APOE4 gene"

This is indecipherable — Preceding unsigned comment added by 8.225.200.133 (talk) 22:21, 5 November 2012 (UTC)

“ Drug Interactions - PRADAXA (dabigatran etexilate)

http://www.pradaxapro.com/drug-interactions.jsp

Drug Interactions | PRADAXA (dabigatran etexilate) ... Drug interactions 3 ... Protamine sulfate and vitamin K are not expected to affect dabigatran anticoagulant …

Pradaxa interacts with vitamin K antagonists (warfarin) but not with vitamin K.”

--Ocdnctx (talk) 04:40, 19 September 2012 (UTC)

I've just made the thing about new anticoagulants more general. We could also mention apixaban and edoxaban if we wanted... I gave the chemical names instead of the trade names. The editor did something weird on my first attempt, which is why the entire section got deleted. Hopefully it's OK now! Cloning jedi (talk) 15:06, 7 February 2013 (UTC)

sources of vitamin k table shows incorrect figures for raw and cooked food. they should be switched as it appears that food is gaining vitamins after cooking. or is this meant to demonstrate that more vitamins are absorbed from from cooked food must show

ources of vitamin k table shows incorrect figures for raw and cooked food. they should be switched as it appears that food is gaining vitamins after cooking. or is this meant to demonstrate that more vitamins are absorbed from from cooked food must show clearly — Preceding unsigned comment added by 86.5.59.182 (talk) 19:44, 6 November 2012 (UTC)

Who is this article aimed at?

When a layman goes to an encyclopedia he wants to have an explanation of something he perhaps knows nothing about. This article is totally incomprehensible to a layman. The first paragraph has nine links to try to explain what it is talking about - it fails on all counts.

I despair when I see a Wikipedia article written by 'experts' who assume everyone knows what they are talking about. If we did, we wouldn't look up the subject on Wikipedia.

I looked up Vitamin K in Simple [sic] English and found out exactly what I was looking for. A clear concise explanation of Vitamin K. Cannonmc (talk) 03:00, 28 January 2013 (UTC)

Nonsensical sentence

"Menaquinone is not inhibited by salicylates as happens with K1, so menaquinone supplementation can alleviate the chronic vitamin K deficiency caused by long-term aspirin use." This is completely wrong. Aspirin is not an Vitamin K antagonist nor does it interfere with Vitamin K metabolism in any way. The author obviously confused Aspirin with the warfarin like drugs. BUT in this case it's known that K2 interferes with the action of those drugs just like K1. — Preceding unsigned comment added by 77.180.28.159 (talk) 10:39, 24 July 2013 (UTC)

There are studies showing salicylate interfering with K1 metabolism but I can find no reference that long-term aspirin use caused "chronic vitamin K deficiency". Nor can I find any reference that concludes that the menaquinones are free from any such interference. That section warrants removal as currently written.

http://www.ncbi.nlm.nih.gov/pubmed/3726797

http://www.ncbi.nlm.nih.gov/pubmed/6136582

Liberato (talk) 08:43, 25 September 2016 (UTC)

Longstanding copyright violations

So I saw some suspected vandalism [6], but since the claim was unsourced either way, I went to seek a source. What I found was that whole paragraph was in [7], published January 2001. I discovered this material was added in December 2001 [8]. The first paragraph in the "Structures of K-vitamins" section is also taken from that source. What I've done is removed all the material from that section of the infringing edit which remains in the article up to today. I suspect the rest of the material in the other sections is also copyright infringement, but I'm not sure. If anyone wants to take a look, that would be great. --Atethnekos (Discussion, Contributions) 19:34, 4 October 2013 (UTC)

Vitamin K and memory

There should be a section dealing specifically with memory and vitamin K.

One link of many is here Fletcherbrian (talk) 02:08, 15 May 2014 (UTC)

That link is dead. There are epidemiology studies suggesting low vitamin K intake or status correlates to cognitive impairment in older adults, but lower K could be due to changes in diet as a consequence of impairment. No prospective clin trials (no reviews either). One trial tracked 10 years of people on or not on warfarin (vitamin K antagonist). Results were no change in rate of mental decline versus not on the drug. (Ferland G, et al. Vitamin K Antagonists and Cognitive Function in Older Adults: The Three-City Cohort Study. J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1356-62.) David notMD (talk) 19:05, 24 March 2017 (UTC)

Kellog's Special K

When I was a kid in the 1960s Kellog's Special K was touted as being a good source of vitamin K and somehow therefore healthy for the heart.

There's no or very little vitamin K in Special K now, if there ever was any in the first place.Fletcherbrian (talk) 16:46, 22 May 2014 (UTC)

Split this page

This page should be split into three, K, K1, K2, because K1 and K2 are so different that they should be clearly separated. 24.6.132.239 (talk) 15:35, 5 November 2014 (UTC)

There are already articles about Vitamin K2 and Phylloquinone. Mindmatrix 16:31, 5 November 2014 (UTC)

natto

this article says over 1000mcg K2 in natto, but the natto article says below 30, and the same small number is listed in wolfram-alpha. what is the explanation for such a discrepancy? Krisztián Pintér (talk) 13:00, 16 March 2015 (UTC)

Units!

The table for k1 had units of micrograms while the reference had units of millicentigrams. Are the other ues of micrograms correct? Colonel hack (talk) 23:19, 7 August 2015 (UTC) But its source says micrograms, so I reverted my edit but this might should still be checked up on. Colonel hack (talk) 02:06, 8 August 2015 (UTC)

Review of vitamin K cycle

doi:10.1111/jth.13217 JFW | T@lk 10:09, 20 December 2015 (UTC)

Dietary Reference Intakes (DRIs)

I am creating the same format for DRIs for all vitamins. That is a U.S.- based system that identifies Estimated Average Requirements (EARs), Recommended Dietary Allowances (RDAs), or Adequate Intakes (AIs) if there is not enough information to establish EARs and RDAs, plus Tolerable Upper Intake Levels (ULs). Another major regulatory agency that has established ULs is the European Food Safety Authority (EFSA). ULs for both are provided, as they often differ. If there is a UL (for some vitamins none has been determined) then rationale should be covered in a Toxicity section. In addition to DRIs, the U.S. also established Daily Value, using it on food and dietary supplement labels as % DV. DVs were based on older RDAs and as of 2016 have never been updated to reflect the newer DRIs. Thus, often a product has 100% DV not same as 100% RDA. Examples given for each vitamin. What I have written can be improved. It lacks EFSA or other major country RDAs. It lacks an estimate of what percentages of people are deficient - although that is often covered in a separate section on deficiency and consequences of deficiency. I am creating this Subject in all of the Talk pages of the nutrients entries I have edited. Comments and improvements are welcome.David notMD (talk) 12:08, 14 May 2016 (UTC)

Text on Daily Values changed to reflect official changes. For most nutrients the 100% DV was revised lower. Vitamin K was one of a few revised higher (vitamin D, vitamin C).David notMD (talk) 18:01, 9 July 2016 (UTC)

Anticoagulant drug interactions

"Sometimes small amounts of vitamin K (one milligram per day) are given orally to patients taking warfarin so that the action of the drug is more predictable."

The NIH reference given for that sentence does not support the 1mg per day statement. It suggests not taking any supplements at all unless approved by your physician. It also does not seem intuitively correct because 1 mg does not seem small for a substance (K₁) that is usually measured in mcg. The reference only suggests keeping your dietary levels consistent. So, can whoever added that one milligram per day sentence please document it. Liberato (talk) 03:08, 13 June 2016 (UTC)

_______________________________________________________________________________________ — Preceding unsigned comment added by Liberato (talk • contribs) 10:25, 27 September 2018 (UTC)

Source for some history of synthetic Vitamin K1

There is some interesting discussion around pages 169, 172 and 228 of the book The Scientific method by Louis F. Fieser about Vitamin K1 around the time it was being first isolated and synthesised. It also talks about a cat (Syn Kai Pooh) named after synthetic Vitamin K1

http://library.sciencemadness.org/library/books/the_scientific_method.pdf — Preceding unsigned comment added by Idyllic press (talk • contribs) 23:32, 20 July 2019 (UTC)

Foundations 2 2019, Group 5a goals

1) reorder sections and create a new "Medical Uses" section. merge "health effects" and "pediatric injections" sections into this new section. Reorder so that this section is after chemistry, physio, biochem sections. 2) expand on the use of Vitamin K as an antidote for over anticoagulation 3) expand on the use of Vitamin K injections in children

Kshim054 (talk) 21:37, 29 July 2019 (UTC)