Talk:Hepatitis E/GA1

GA Review

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Reviewer: Casliber (talk · contribs) 20:29, 14 August 2019 (UTC)[reply]

I'll take a look. I will make straightforward changes as I go and jot queries below. Please revert if I accidentally change the meaning. Cas Liber (talk · contribs) 20:29, 14 August 2019 (UTC)[reply]

Cas Liber thank you--Ozzie10aaaa (talk) 20:50, 14 August 2019 (UTC)[reply]

~~I'd link incubation period, zoonosis, capsid.~~

Done incubation period, capsid while 'zoonosis' was already linked via 'zoonoses' (alternate spelling)

~~Convert centigrade to fahrenheit~~

Done [1] and [2] placed in parenthesis

After a short prodromal phase symptoms lasting from days to weeks follow. - are there any symptoms in the prodromal phase? Also, "days to weeks" is a bit vague/noninformative for the reader

Done agree have clarified the text in question per..."Hepatitis E". www.who.int. Retrieved 17 August 2019....an initial phase of mild fever, reduced appetite, nausea and vomiting

~~How long do/can chronic infections last?~~

per review....Kamar, Nassim; Izopet, Jacques; Dalton, Harry R. "Chronic Hepatitis E Virus Infection and Treatment". Journal of Clinical and Experimental Hepatology. 3 (2): 134–140. doi:10.1016/j.jceh.2013.05.003. ISSN 0973-6883. Retrieved 17 August 2019....chronic Hepatitis E can be diagnosed at 3 months however as to how long chronic Hepatitis E can last (according to this review) is not as obvious, "A few liver-transplant patients with chronic HEV infection were given a 3-month (n = 3) or a 12-month (n = 1) course of pegylated interferon (135 μg/week)", according to the author within the first year chronic Hepatitis E can cause complications. I therefore have inserted [3] the time to diagnosis of the chronic condition.Should you wish me to elaborate on how long the chronic condition can last (and almost invariably its potential for complications) then I will do so

Adding the 3 month diagnosis is good Cas Liber (talk · contribs) 14:31, 17 August 2019 (UTC)[reply]

For some of these reported conditions the relationship is tenuous, but for several neurological and blood conditions the relationship appears causal - do you mean the ones listed below? Or is this all and only some are causal?

Done agree have added [4] per...Bazerbachi, Fateh; Haffar, Samir; Garg, Sushil K; Lake, John R. "Extra-hepatic manifestations associated with hepatitis E virus infection: a comprehensive review of the literature". Gastroenterology Report. 4 (1): 1–15. doi:10.1093/gastro/gov042. ISSN 2052-0034. Retrieved 17 August 2019.... "According to the available data, HEV infection appears to be strongly associated with acute pancreatitis, neurological disorders (with primarily dominant peripheral nerve involvement, most commonly manifested as Guillain-Barré syndrome, followed by neuralgic amyotrophy), hematological diseases (hemolytic anemia due to glucose phosphate dehydrogenase deficiency, and severe thrombocytopenia), glomerulonephritis, and mixed cryoglobulinemia. More data are needed to clarify whether an association exists with musculoskeletal or other immune-mediated manifestations"

~~As mentioned, the incubation period following exposure to the hepatitis E virus ranges from 3 to 8 weeks, with a mean of 40 days~~ ~~- you've already mentioned this, in fact teh mean should be at the top mention. I'd say something like, "The length of the incubation period means that/leads to..." or something~~

Done agree have added[5]

The article has two different cooking temperatures and times...and one is more confident than the other...

Done agree have added [6]

Err, there is still the discrepancy....Cas Liber (talk · contribs) 14:33, 17 August 2019 (UTC)[reply]

per "Hepatitis E Virus and Food | FAQ | Food Safety Authority of Ireland". www.fsai.ie. Retrieved 17 August 2019.... "suggested that 71oC for 20 minutes was needed to kill the virus completely. Other studies in various food matrices including pig liver, suggest that 71oC for 10 minutes or even 70oC for 5 minutes would be sufficient to kill the hepatitis E virus"...the source indicated different times for different temperatures

Problem is, then, the two different values in two different parts of the article just looks like two inconsistent parts of article. Would be best in same place of article somehow Cas Liber (talk · contribs) 12:57, 20 August 2019 (UTC)[reply]

~~Has the chinese vaccine been used outside China?~~

per [7] Chinese-HEV vaccine, clinical trials in the United States have started, however there has been no approval/license[8]

~~Also, if the Ugandan outbreak was the largest, it probably should be expanded a bit to give proper weighting. Also, was the vaccine used in any of these outbreaks?~~

Done agree have added[9]
was unable to find periods of use of HEV vaccine, furthermore per WHO...the absence of sufficient information at this time,WHO does not make a recommendation on the introduction of the vaccine for routine use in national programmes...where HEV is common "Summary of the WHO Position Paper on Vaccine against Hepatitis E Virus(HEV)" (PDF). WHO.int. Retrieved 17 August 2019. {{cite web}}: no-break space character in |title= at position 8 (help)

Outbreaks of epidemic hepatitis E most commonly occur after heavy rainfalls and monsoons because of their disruption of water supplies - probably better to explain this a little more - i.e. contamination of drinking water with effluent (I guess). Cas Liber (talk · contribs) 22:29, 17 August 2019 (UTC)[reply]

Done agree have added with reference[10]

What is the rationale behind the para splits in Recent outbreaks section? The first one is the largest outbreak...but then you have an African and Asian one in the next para...aaand an African one in the last.

An outbreak was reported in Namibia in southern Africa, in January 2018, the total infected is reported as 490 - is written like it was just added...and left. Needs to be reworded to fit with the next two sentences.

I just came across this article, which should be included - other salient facts - historically we used to call other viral hepatitises non-A non-B hepatitis. It also cites this paper, which seems to be about the discovery of the virus.

The Webb article also states that Hep E is the most common cause of viral hepatitis worldwide. That should be included prominently if true.

The Webb article also states in epidemiology "Young adults are most commonly affected, especially the 15–35 age group, and men are more likely to be infected than women" - not mentioned in this article.

The Webb article also mentions renal complications

The Webb article also has a table "Who should we test for HEV?" - article lacks information on indications for testing..

The Webb article gives 2-8 weeks as incubation period (vs article's 3-8 weeks. I'd take a review article over a fact sheet but might be good to figure out why there is a discrepancy and think of a rationale to go with one or the other.