Talk:Fluphenazine

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Fluphenazine is more potent than Haloperidol?

"It belongs to the piperazine class of phenothiazines and is extremely potent; more potent than haloperidol and around fifty to seventy times the potency of chlorpromazine."

While fluphenazine certainly is a highly potent neuroleptic, I don't think it's more potent than haloperidol. Most sources I have state, that the neuroleptic potency of fluphenazine dihydrochloride administred orally or intramusculary is somewhere between 30 and 40 (maximum 50) chlorpromazine-equivalents; haloperidol is stated to have CPZeq. of 50 in all sources I have to my disposition; thus, fluphenazine is slightly less, or maximaly equaly potent, compared to haloperidol; in one publication, intramuscular fluphenazine decanoate is stated to have a potency of about 115 - 130 CPZeq's, but then again, haloperidol decanoate i.m. is stated to have potency of 110 - 125 CPZeq.--84.163.86.56 00:12, 1 May 2007 (UTC)[reply]

Advertising images

Thoughts out there about these old Prolixin ads? I'm in favor of keeping the images, as they provide some visual context for the era when these drugs were marketed, in the same way that the Coca-Cola page has advertisements in the article. Andrew73 13:46, 24 July 2007 (UTC)[reply]

Hmm. These are both non-free images so we shouldn't be using them without a good reason (see WP:NFC#Policy for more). If they are supposed to illustrate the product's promotion and advertising, why does the article make no mention of this? Neither of the images even has a caption. And why two unfree images? Cheers, --KFP (talk | contribs) 11:49, 25 July 2007 (UTC)[reply]

Good points. I've added captions to show that they are advertisements. There are no free equivalents, and I think they do serve an encyclopedic role. If they are okay on the Coca-Cola page, they should similarly be okay here. Andrew73 12:23, 25 July 2007 (UTC)[reply]

Prodrugs?

The article lists brand names for various ester forms. Does this mean that fluphenazine is not given directly, but rather as esters that are metabolized to fluphenazine? Or are fluphenazine decanoate, etc. salts, not esters? Either way, the article should explain. —Preceding unsigned comment added by 72.94.164.21 (talk) 00:04, 20 January 2010 (UTC) those are different salt forms of the drug — Preceding unsigned comment added by 159.238.36.19 (talk) 15:59, 2 October 2013 (UTC)[reply]

That doesn't works that way; in depot form, fluphenazine is in form of ester, because ester (e.g. decanoate) is slowly hydrolysed (weeks, even months) and thus fluphenazine is slowly released, just that way as haloperidol depot. Salt would be released nearly without delay, thus it wouldn't work as depot. 193.242.143.1 (talk) 15:11, 25 May 2015 (UTC)[reply]

Fluphenazine decanoate half life is in correct

http://journals.lww.com/psychopharmacology/Abstract/1990/10060/Single_Dose_Pharmacokinetics_of_Fluphenazine_after.7.aspx

Here, in 9 patients, they gave 1 injection of fluphenazine decanoate, plasma level after 26 days didn't decrease to 50% .. ppl said 2 weeks half life — Preceding unsigned comment added by 109.67.91.192 (talk) 00:57, 31 July 2017 (UTC)[reply]

calmodulin antagonist ?

In this paper, it says fluphenazine is a calmodulin antagonist, but on this wiki page it says its mechanism is not entirely clear, except that it might have something to do with with dopamine receptor. Should this reference and a few words about calmodulin be added? https://onlinelibrary.wiley.com/doi/epdf/10.1046/j.1365-2958.2002.03165.x Jajava (talk) 14:48, 20 August 2019 (UTC)[reply]