Antibody-oligonucleotide conjugate
Antibody-oligonucleotide conjugates or AOCs belong to a class of chimeric molecules combining in their structure two important families of biomolecules: monoclonal antibodies and oligonucleotides.
History
AOCs combine the targeting capabilities of monoclonal antibodies with numerous functional modalities of oligonucleotides. Applications with AOCs are numerous, including imaging, detection and targeted therapeutics.[1]
References
- ^ Dovgan, Igor; Koniev, Oleksandr; Kolodych, Sergii; Wagner, Alain (24 July 2019). "Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents". Bioconjugate Chemistry. doi:10.1021/acs.bioconjchem.9b00306. ISSN 1043-1802. Retrieved 26 August 2019.