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Julius Marmur

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Julius Marmur made significant contributions to the science of molecular biology. In particular, his discovery, while working in the laboratory of Paul Doty at Harvard, that the denaturation of DNA was reversible and depended on salt and GC content, had a major impact on how scientists thought about DNA, and how DNA could be handled in vitro; thus, this discovery was a cornerstone of the recombinant DNA revolution. Marmur spent most of his professional career at the Albert Einstein College of Medicine (AECOM), Bronx, NY based medical school affiliated with Yeshiva University.

Sadly, AECOM, while supporting an annual symposium in Julius' honor (http://www.aecom.yu.edu/home/search_page.asp) does not list his biography on their web site.

A standard work on the history of molecular biology, such as Horace Freeland Judson's "The eigth day of creation' may be consulted.

In an historical context, Julius can be seen as a figure who bridged the work of the 1940s and 50s, as exemplified by Rollin Hotchkiss, with the work of the 70s and later.

Two Articles written by scientists: Szybalski W. In memoriam. Julius Marmur (1926-1996). Gene. 1997 Dec 19;204(1-2):1-3.

Doty P. Julius Marmur (1926-96) Nature. 1996 Jun 13;381(6583):557.

Key Paper MARMUR J, DOTY P. Determination of the base composition of deoxyribonucleic acid from its thermal denaturation temperature. J Mol Biol. 1962 Jul;5:109-18.