Yoshihiro Kawaoka
Yoshihiro Kawaoka | |
|---|---|
| Born | November 14, 1955 Kobe, Japan |
| Alma mater | Hokkaido University |
| Occupation(s) | Virologist, professor at University of Wisconsin-Madison and University of Tokyo |
| Known for | Studies of influenza and Ebola viruses |
Yoshihiro Kawaoka (河岡 義裕, Kawaoka Yoshihiro, born November 14, 1955) is a virologist specializing in the study of the influenza and Ebola viruses. He holds a professorship in virology in the Department of Pathobiological Sciences at the University of Wisconsin-Madison, USA, and at the University of Tokyo, Japan.
Following the West African Ebola virus epidemic of 2014, Kawaoka began development of an Ebola vaccine working in close coordination with Dr. Alhaji N'jai a toxicologist at the University of Wisconsin–Madison and his non-profit organization Project 1808, Inc.[1]
Controversial experiment
Kawaoka reinvented a new virus based on H5N1, which he revealed to the public in 2011.[2] For now, no known vaccine has been found. Despite the great disturbance he has caused, Kawaoka argued that "it is part of valuable scientific research".[3][deprecated source] His research was halted by a moratorium issued from the US government in 2014. However in 2019 he was allowed to resume the research.[4][5]
Dan Brown mentioned the experiment in his novel Inferno.[6]
Recognition
- 2006 - Robert Koch Prize (with Peter Palese)[7]
- 2011 - Medal with Purple Ribbon
- 2013 - Members of the United States National Academy of Sciences
- 2014 - Popular Mechanics Breakthrough Award
- 2015 - Carlos J. Finlay Prize for Microbiology
- 2016 - Japan Academy Prize
- 2018 - Sir Michael Stoker Prize[8]
Selected publications
- Jasenosky, Luke D; Neumann, Gabriele; Lukashevich, Igor; Kawaoka, Y (2001-06-01). "Ebola virus vp40-induced particle formation and association with the lipid bilayer". J Virol. 75 (11): 5205–5214. doi:10.1128/JVI.75.11.5205-5214.2001. OCLC 6965132858. PMC 114926. PMID 11333902.
- Watanabe, Tokiko; Watanabe, Shinji; Ito, Hiroshi; Kida, Hiroshi; Kawaoka, Y (2001-06-15). "Influenza A virus can undergo multiple cycles of replication without m2 ion channel activity". J Virol. 75 (12): 5656–5662. doi:10.1128/jvi.75.12.5656-5662.2001. PMC 114278. PMID 11356973. Retrieved 2018-03-26.
- Schultz-Cherry, S; Dybdahl-Sissoko, N; Neumann, G; Kawaoka, Y; Hinshaw VS (2001-09-01). "Influenza Virus NS1 Protein Induces Apoptosis in Cultured Cells". J Virol. 75 (17): 7875–7881. doi:10.1128/jvi.75.17.7875-7881.2001. ISSN 0022-538X. OCLC 120974346. PMID 11483732.
- Hatta, M; Gao, P; Halfmann, P; Kawaoka, Y (2001-09-07). "Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses". Science. 293 (298): 1840–1842. Bibcode:2001Sci...293.1840H. doi:10.1126/science.1062882. ISSN 0036-8075. OCLC 95118961. PMID 11546875.
- Goto, Hideo; Wells, Krisna; Takada, Ayato; Kawaoka, Y. (2001-10-01). "Plasminogen-binding activity of neuraminidase determines the pathogenicity of influenza A virus". J Virol. 75 (19): 9297–9301. doi:10.1128/jvi.75.19.9297-9301.2001. ISSN 0022-538X. OCLC 6965138857. PMC 114497. PMID 11533192.
- Kobasa, Darwyn; Wells, Krisna; Kawaoka, Yoshihiro (2001-12-01). "Amino Acids Responsible for the Absolute Sialidase Activity of the Influenza A Virus Neuraminidase: Relationship to Growth in Duck Intestine". J Virol. 75 (23): 11773–11780. doi:10.1128/jvi.75.23.11773-11780.2001. OCLC 4639538185. PMC 114763. PMID 11689658.
- Kawaoka, Y; Neumann, Gabriele (2012). Influenza Virus : Methods and Protocols. Methods in Molecular Biology, Methods and Protocols, 865. Vol. 865. Springer. doi:10.1007/978-1-61779-621-0. ISBN 978-1-61779-620-3.
- Watanabe, Tokiko; Kawaoka, Yoshihiro (June 2016). "Ebora shukketsu netsu no seiatsu ni mukete : Wakuchin kaihatsu to shierareone de no kenkyu" [Control of Ebola hemorrhagic fever : vaccine development and our Ebola project in Sierra Leone]. Virus (in Japanese). 66 (1): 53–62. doi:10.2222/jsv.66.53. ISSN 0042-6857. OCLC 6807788600. PMID 28484179.
References
- ^ "Project 1808".
- ^ "Scientists Brace for Media Storm Around Controversial Flu Studies". 2011-11-24.
- ^ Guy Walters (3 July 2014). "Are we mad to have let a maverick scientist create a virus that could wipe out 400 million people?". MailOnline. Retrieved 4 July 2014.
- ^ https://madison.com/wsj/news/local/health-med-fit/uw-madison-scientist-allowed-to-resume-controversial-flu-research/article_7778777c-75b8-5da0-beda-3232cb8083ef.html
- ^ "EXCLUSIVE: Controversial experiments that could make bird flu more risky poised to resume". 2019-02-09.
- ^ Dan Burstein, Secrets of Inferno: In the Footsteps of Dante and Dan Brown. Story Plant, 2013.
- ^ Robert-Koch-Stiftung: Robert Koch Award. Retrieved 4 July 2014.
- ^ "Sir Michael Stoker Prize & Lecture 2018".
External links
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- Articles with deprecated sources from September 2019
- Living people
- 1955 births
- People from Kobe
- Influenza researchers
- American virologists
- Japanese virologists
- Japanese microbiologists
- University of Wisconsin–Madison faculty
- University of Tokyo faculty
- Hokkaido University alumni
- Recipients of the Medal of Honor (Japan)
- Foreign associates of the National Academy of Sciences
- Japanese scientist stubs