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This is an old revision of this page, as edited by D A Patriarche (talk | contribs) at 18:41, 6 May 2020 (→Methamphetamine as neurotoxin: add to disc -- relative toxicity related compounds). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.


Methamphetamine as neurotoxin

The article calls meth a "neurotoxin and" cns stimulant. This is technically correct, I guess, since, as mentioned in the article cited, meth is neurotoxic. Pretty much all stimulants that act on norepinephrine and dopamine are neurotoxic in high enough doses over long enough periods of time. It's silly to include that neurotoxicity in the drug's definition. I'm rewriting. Quodfui (talk) 20:32, 19 November 2014 (UTC)[reply]

I don't have time to deal with this - there are some good sources there that I don't want to remove, but as that section is set up right now it has a pov beyond that expressed in its sources. This article seems to have devolved into a discussion of stimulants as street drugs even though there are a variety of legitimate uses for which they are prescribed. Quodfui (talk) 20:46, 19 November 2014 (UTC)[reply]

Methamphetamine happens to possess uniquely individual properties among which include its comparative degree of neuronal toxicity even compared to other hard or "amphetamine-type" stimulants. This is simply the truth - the DEA can go fly a kite as far as I'm concerned, but they are veracious in stating to the public methamphetamine is uniquely toxic to the human brain system. I pass no judgment on Desoxyn users (usage thereof may be had without serious critical toxicity if intelligently done) but yeah, meth is heavy, hard stuff. We must report reality. Only cocaine and meth rival each other in brain damage potential in the stimulant group. — Preceding unsigned comment added by 2602:304:B34B:A940:F051:AB0F:3A76:DE48 (talk) 04:27, 19 June 2015 (UTC)[reply]

Methamphetamine is far from being "uniquely" toxic. It seems to me a more useful presentation would be a discussion of relative neurotoxicity of different substituted phenethylamines & related psychedelics. In my college days I came across a paper studying just this. Some compounds caused severe irreversible brain damage after a single dose, which makes meth look benign. I was sufficiently horrified to avoid all such drugs not just through the glorious 60s but for the next 40 years.
IIRC, the chief culprit was the position & number of hydroxyl groups. Shift an -OH group one position and a relatively safe compound became acutely toxic. This is of more than academic interest when the possibility of contaminated street drugs is considered. I don't have much hope of finding that 1960s paper now, but there must be more recent work.
The technical details don't belong in this article, but I think a brief mention is in order here. I'm putting this article on my "to-do" watchlist as I see other bits that could use improving, but as usual feel free to jump in. --D Anthony Patriarche, BSc (talk) 18:41, 6 May 2020 (UTC)[reply]

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MDMA is not a stimulant and should not be listed in this article as one

MDMA is a psychedelic which means it is between stimulant and hallucinogen. It's inclusion in the stimulants list is inappropriate. If we are including MDMA as a pure stimulant we would also have to include LSD, DMT, DPT ect which all have a very significant stimulating effect on humans. Boilingorangejuice (talk) 20:06, 29 May 2016 (UTC)[reply]

Do you have a source for this definition of psychedelic drug? It doesn't seem to match our article. Sizeofint (talk) 20:21, 29 May 2016 (UTC)[reply]
Also MDMA has reliable sources stating it is a stimulant. Sizeofint (talk) 22:00, 29 May 2016 (UTC)[reply]
Well, given that reasoning I will be adding LSD and psilocybin to the stimulants list given that while they are mainly known for their hallucinogenic effects they are also stimulating. Boilingorangejuice (talk) 07:42, 8 June 2016 (UTC)[reply]
If you find WP:MEDRS sources stating LSD and psilocybin are stimulants then do so. I have not seen any however. Sizeofint (talk) 09:21, 8 June 2016 (UTC)[reply]

MDMA is an amphetamine, why separete it?

In the introductory section MDMA is listed as separeted from the amphetamines: It is estimated that the percent of the population that has abused amphetamines, cocaine and MDMA combined is between .8% and 2.1%; Because MDMA is an amphetamine I'll edit this phrase to: It is estimated that the combined percentage of the population that has abused amphetamines or cocaine is between 0.8% and 2.1%.". — Preceding unsigned comment added by Gottliber (talk • contribs) 22:30, 13 October 2017 (UTC)[reply]

Fair point.  Fixed it. Seppi333 (Insert 2¢) 03:32, 14 October 2017 (UTC)[reply]

"Phenatine" listed at Redirects for discussion

An editor has asked for a discussion to address the redirect Phenatine. Please participate in the redirect discussion if you wish to do so. Hairy Dude (talk) 14:25, 30 January 2020 (UTC)[reply]

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