Choline transporter-like protein 4

SLC44A4
Identifiers
Aliases	SLC44A4, C6orf29, CTL4, NG22, TPPT, solute carrier family 44 member 4, DFNA72, hTPPT1
External IDs	OMIM: 606107; MGI: 1917379; HomoloGene: 11359; GeneCards: SLC44A4; OMA:SLC44A4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,879,046 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,149,412 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right uterine tube; ; rectum; ; duodenum; ; olfactory zone of nasal mucosa; ; gallbladder; ; prostate; ; islet of Langerhans; ; human kidney; ; appendix;
	Top expressed in
	left colon; ; epithelium of stomach; ; ileum; ; intestinal villus; ; Ileal epithelium; ; mucous cell of stomach; ; right kidney; ; pyloric antrum; ; jejunum; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	choline transmembrane transporter activity; thiamine pyrophosphate transmembrane transporter activity;
Cellular component	extracellular exosome; membrane; integral component of membrane; plasma membrane; apical plasma membrane;
Biological process	acetylcholine secretion; phosphatidylcholine biosynthetic process; transmembrane transport; acetylcholine biosynthetic process; positive regulation of cell growth; choline transport; thiamine pyrophosphate transmembrane transport; otolith formation; neuromast hair cell development;
	Sources:Amigo / QuickGO
Orthologs
	80736
	70129
ENSG00000232180; ENSG00000204385; ENSG00000231479; ENSG00000228263; ENSG00000206378;
	ENSG00000235336; ENSG00000229077; ENSG00000203463
	ENSMUSG00000007034
	Q53GD3
	Q91VA1
	NM_025257; NM_001178044; NM_001178045
	NM_023557
	NP_001171515; NP_001171516; NP_079533
	NP_076046
	Wikidata
View/Edit Human	View/Edit Mouse

Choline transporter-like protein 4 is a protein that in humans is encoded by the SLC44A4 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c ENSG00000204385, ENSG00000231479, ENSG00000228263, ENSG00000206378, ENSG00000235336, ENSG00000229077, ENSG00000203463 GRCh38: Ensembl release 89: ENSG00000232180, ENSG00000204385, ENSG00000231479, ENSG00000228263, ENSG00000206378, ENSG00000235336, ENSG00000229077, ENSG00000203463 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000007034 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (Mar 2000). "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins". Proc Natl Acad Sci U S A. 97 (4): 1835–40. Bibcode:2000PNAS...97.1835O. doi:10.1073/pnas.030339697. PMC 26522. PMID 10677542.
^ Traiffort E, Ruat M, O'Regan S, Meunier FM (Feb 2005). "Molecular characterization of the family of choline transporter-like proteins and their splice variants". J Neurochem. 92 (5): 1116–25. doi:10.1111/j.1471-4159.2004.02962.x. PMID 15715662. S2CID 30921826.
^ "Entrez Gene: SLC44A4 solute carrier family 44, member 4".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Uhl J, Penzel R, Sergi C, et al. (2002). "Identification of a CTL4/Neu1 fusion transcript in a sialidosis patient". FEBS Lett. 521 (1–3): 19–23. doi:10.1016/S0014-5793(02)02748-5. PMID 12067718. S2CID 23180217.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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[refGRCh38Ensembl-1] ENSG00000204385, ENSG00000231479, ENSG00000228263, ENSG00000206378, ENSG00000235336, ENSG00000229077, ENSG00000203463 GRCh38: Ensembl release 89: ENSG00000232180, ENSG00000204385, ENSG00000231479, ENSG00000228263, ENSG00000206378, ENSG00000235336, ENSG00000229077, ENSG00000203463 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007034 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10677542-5] O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (Mar 2000). "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins". Proc Natl Acad Sci U S A. 97 (4): 1835–40. Bibcode:2000PNAS...97.1835O. doi:10.1073/pnas.030339697. PMC 26522. PMID 10677542.

[pmid15715662-6] Traiffort E, Ruat M, O'Regan S, Meunier FM (Feb 2005). "Molecular characterization of the family of choline transporter-like proteins and their splice variants". J Neurochem. 92 (5): 1116–25. doi:10.1111/j.1471-4159.2004.02962.x. PMID 15715662. S2CID 30921826.

[entrez-7] "Entrez Gene: SLC44A4 solute carrier family 44, member 4".

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Choline transporter-like protein 4

See also

References

Further reading