β-Naphthoflavone

β-Naphthoflavone
Names
	IUPAC name Benzo[5,6]flavone
	Systematic IUPAC name 3-Phenyl-1H-naphtho[2,1-b]pyran-1-one
	Other names 5,6-Benzoflavone, BNF
Identifiers
CAS Number	6051-87-2 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:77013 ;
ChEMBL	ChEMBL26260 ;
ChemSpider	2271 ;
DrugBank	DB06732 ;
ECHA InfoCard	100.025.417
PubChem CID	2361;
UNII	1BT0256Y8O ;
CompTox Dashboard (EPA)	DTXSID8030423 ;
	InChI InChI=1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H Key: OUGIDAPQYNCXRA-UHFFFAOYSA-N ; InChI=1/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H Key: OUGIDAPQYNCXRA-UHFFFAOYAM;
	SMILES O=C\1c3c(O/C(=C/1)c2ccccc2)ccc4c3cccc4;
Properties
Chemical formula	C19H12O2
Molar mass	272.303 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

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β-Naphthoflavone, also known as 5,6-benzoflavone, is a potent agonist of the aryl hydrocarbon receptor and as such is an inducer of such detoxification enzymes as cytochromes P450 (CYPs) and uridine 5'-diphospho-glucuronosyltransferases (UGTs).^[1] β-Naphthoflavone is a putative chemopreventive agent.^[2]

References

^ Chlouchi A, Girard C, Bonet A, Viollon-Abadie C, Heyd B, Mantion G, Martin H, Richert L (2007). "Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture". Planta Med. 73 (8): 742–7. doi:10.1055/s-2007-981548. PMID 17599282. S2CID 260281088.
^ Izzotti A, Bagnasco M, Cartiglia C, Longobardi M, Camoirano A, Tampa E, Lubet RA, De Flora S (2005). "Modulation of multigene expression and proteome profiles by chemopreventive agents". Mutat Res. 591 (1–2): 212–23. doi:10.1016/j.mrfmmm.2005.03.032. PMID 16083920.

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[1] Chlouchi A, Girard C, Bonet A, Viollon-Abadie C, Heyd B, Mantion G, Martin H, Richert L (2007). "Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture". Planta Med. 73 (8): 742–7. doi:10.1055/s-2007-981548. PMID 17599282. S2CID 260281088.

[2] Izzotti A, Bagnasco M, Cartiglia C, Longobardi M, Camoirano A, Tampa E, Lubet RA, De Flora S (2005). "Modulation of multigene expression and proteome profiles by chemopreventive agents". Mutat Res. 591 (1–2): 212–23. doi:10.1016/j.mrfmmm.2005.03.032. PMID 16083920.

[1]

[2]

See also

References