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CSL Behring

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CSL Behring LLC
ASX: CSL
IndustryBiopharmaceutical, health care
HeadquartersKing of Prussia, Pennsylvania
Key people
Paul McKenzie, CEO and Managing Director of CSL Limited
Number of employees
27,000+[1]
ParentCSL Limited
Websitewww.cslbehring.com

CSL Behring is a biopharmaceutical company, manufacturing plasma-derived and recombinant therapeutic products.[2] The company is a combination of Behringwerke, founded in 1904 in Marburg, Germany by Emil von Behring, and the Commonwealth Serum Laboratories (CSL), established in Australia in 1916 to provide vaccines to the people of Australia, as well as other companies acquired since 2004.

About

CSL Behring's parent company, CSL Limited, is headquartered in Melbourne, Victoria, Australia.[3] Previously known as ZLB Behring, the company's history dates back to 1904 when Behringwerke was founded in Germany by Emil von Behring, winner of the first Nobel Prize in Medicine as the inventor of serum therapy or serology.[4] The CSL Behring brand was established in 2007.

CSL Behring operates CSL Plasma. It has over 12,000 employees and more than 270 plasma collection centres covering China, the US, and Europe.[5][6][7]

History

In 1904, Von Behring founded the Behringwerke in Marburg, Germany, for experimental work on disease prevention and the manufacturing of sera and vaccines. In 1913, Behringwerke expanded to produce a gas gangrene antiserum and a cholera vaccine.

The Commonwealth Serum Laboratories (now CSL Ltd.) were established in Australia in 1916 to provide vaccines to the people of Australia and New Zealand. In 1930, CSL released an antivenom for tiger snake bites. In 1944, CSL began producing penicillin for the Australian military.

In 1954, Australian CSL officer Val Bazeley assisted Jonas Salk in producing the experimental polio vaccine used in the first clinical trials in the US. Bazeley returned to Australia to set up production of the Salk vaccine at CSL.

In 1981, Behringwerke introduced Haemate, a human plasma coagulation factor VIII/von Willebrand factor complex, for the treatment of patients with Hemophilia A.

In 1991, CSL Limited was incorporated in Australia. The company went private in 1994 and was listed on the Australian Stock Exchange.

In 2007, ZLB Behring became CSL Behring. In 2009, ZLB Plasma changed its name to CSL Plasma to align with its parent company and opened plasma testing laboratories in Knoxville, Tennessee. That same year, the National Organization for Rare Disorders (NORD) recognised CSL Behring for developing and marketing a treatment in the U.S. for acute bleeding episodes in patients with congenital fibrinogen deficiency, and the Swiss government awarded CSL Behring the Tell Award.

In 2012, the European Organisation for Rare Diseases recognised CSL Behring for developing and manufacturing therapies to treat rare and serious medical conditions with the 2012 EURORDIS Company Award.[8]

Sales and acquisitions

Over the past century, CSL Behring has acquired:

In 2000, the company acquired ZLB from the Swiss Red Cross for $525 million.[9] U.S. plasma collector Nabi, which helped form the world's largest plasma collection network in CSL Plasma, was acquired in 2001.

The company sold Animal Health and acquired the U.S. coagulation-therapy maker Aventis Behring in 2004 for $925 million[10] combining it with ZLB Bioplasma to create ZLB Behring (later CSL Behring). The following year the company sold JRH Biosciences, which the company had acquired in 1994.

Zenyth Therapeutics was acquired in 2006.

Calimmune, a leader in gene-modification and cell-delivery technology,[11] was acquired in 2020 for a reported $91 million.[12]

In 2020, CSL Behring picked up a 2017 option agreement and acquired Vitaeris, a biopharmaceutical company focused on the development of Clazakizumab as a potential treatment option for organ transplant recipients experiencing rejection.

In August 2022, the company finalized its purchase of Vifor Pharma for a reported $11.7 billion.[13]

Offices

The company's United States headquarters are in King of Prussia, Pennsylvania. It has 27,000+ employees in 30 countries. Major manufacturing centers are located in Bern, Switzerland;Marburg, Germany; Kankakee, Illinois; and Broadmeadows, Australia.

References

  1. ^ De Vane, Natalie (October 29, 2020). "CSL Named as One of the World's Best Employers". www.cslbehring.com. CSL Behring. Archived from the original on 2020-11-28. Retrieved February 22, 2021. Forbes magazine has named global biotechnology leader CSL Limited … to its World's Best Employers 2020 list.
  2. ^ "CSL Behring LLC - Company Profile and News". Bloomberg.com. Retrieved 2023-10-16.
  3. ^ "Articles about CSL Behring". BioSpace. Retrieved 2023-09-27.
  4. ^ Nobel Prize in Physiology or Medicine 1901 - Emil von Behring – Biographical. Elsevier Publishing Company, Amsterdam. 1967. p. 16. Retrieved February 22, 2021 – via The Nobel Foundation. … for his work on serum therapy, especially its application against diphtheria … {{cite book}}: |work= ignored (help)
  5. ^ "About CSL Plasma". www.cslplasma.com. CSL Plasma. Archived from the original on 2018-10-30. Retrieved February 22, 2021. … operates one of the world's largest and most sophisticated plasma collection networks, …
  6. ^ "CSL Behring: new approaches against Covid-19". Healthcare Mittelhessen. 2020-08-04. Retrieved 2022-03-27.
  7. ^ "CSL Behring Company Information". Drugs.com. Retrieved 2022-03-27.
  8. ^ "EURORDIS". www.eurordis.org. March 22, 2012. Retrieved January 20, 2020.
  9. ^ "Aventis disposes of Behring unit with $925M sale to Australia's CSL -". www.thepharmaletter.com. Archived from the original on 2012-03-24. Retrieved 2023-10-02.
  10. ^ "Insight Weekly: Bank mergers of equals return; energy tops S&P 500; green bond sales to rise". www.spglobal.com. Retrieved 2023-10-02.
  11. ^ C. S. L. Behring (August 28, 2017). "CSL Behring to Acquire Biotech Company Calimmune and its Proprietary Stem Cell Gene Therapy Platform". CSL Behring. Archived from the original on 2017-08-29. Retrieved February 22, 2021 – via prnewswire.com. …CSL Behring announced today that it has agreed to acquire Calimmune, Inc., …
  12. ^ "*". In Vivo. Retrieved 2023-10-11.
  13. ^ Kansteiner, Fraiser (2 August 2022). "After delay, CSL's $11.7B deal for Vifor poised to close next week". Fierce Pharma. Retrieved 11 October 2023.
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