Lactivicin

Lactivicin
Names
	IUPAC name 2-(4-Acetamido-3-oxo-1,2-oxazolidin-2-yl)-5-oxooxolane-2-carboxylic acid
Identifiers
CAS Number	107167-31-7;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1909427;
ChemSpider	8057612;
PubChem CID	9881937;
CompTox Dashboard (EPA)	DTXSID50910246 ;
	InChI InChI=1S/C10H12N2O7/c1-5(13)11-6-4-18-12(8(6)15)10(9(16)17)3-2-7(14)19-10/h6H,2-4H2,1H3,(H,11,13)(H,16,17) Key: ZUEKKUYIXILDAF-UHFFFAOYSA-N;
	SMILES CC(=O)NC1CON(C1=O)C2(CCC(=O)O2)C(=O)O;
Properties
Chemical formula	C10H12N2O7
Molar mass	272.213 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Lactivicin is a non-beta-lactam antibiotic that is active against a range of Gram-positive and Gram-negative bacteria.^[1] Lactivicin demonstrates a similar affinity for penicillin-binding proteins to beta-lactam antibiotics and is also susceptible to beta-lactamase enzymes.^[2]

References

^ Nozaki Y, Katayama N, Harada S, Ono H, Okazaki H (1989). "Lactivicin, a naturally occurring non-beta-lactam antibiotic having beta-lactam-like action: biological activities and mode of action". J. Antibiot. 42 (10): 84–93. doi:10.7164/antibiotics.42.84. PMID 2493440.
^ Harada S, Tsubotani S, Hida T, Ono H, Okazaki H (1986). "Structure of lactivicin, an antibiotic having a new nucleus and similar biological activities to β-lactam antibiotics". Tetrahedron Letters. 27 (51): 6229–6232. doi:10.1016/S0040-4039(00)85439-8.

External links

"Mechanism Of Unusual Antibiotic". Chemical & Engineering News. 85 (33): 13. August 13, 2007.

[Lactivicin-1] Nozaki Y, Katayama N, Harada S, Ono H, Okazaki H (1989). "Lactivicin, a naturally occurring non-beta-lactam antibiotic having beta-lactam-like action: biological activities and mode of action". J. Antibiot. 42 (10): 84–93. doi:10.7164/antibiotics.42.84. PMID 2493440.

[Lactivicin_discovery-2] Harada S, Tsubotani S, Hida T, Ono H, Okazaki H (1986). "Structure of lactivicin, an antibiotic having a new nucleus and similar biological activities to β-lactam antibiotics". Tetrahedron Letters. 27 (51): 6229–6232. doi:10.1016/S0040-4039(00)85439-8.

[1]

[2]