English: Metaphase cells depleted for CENP-E using RNAi, showing unaligned chromosomes (arrows) which show positive staining for checkpoint proteins Mad1/Mad2. Hec1 and CENP-B label the centromeric region (the kinetochore), and DAPI labels the ADN.
Español: Células en metafase con niveles bajos de CENP-E mediante RNAi, que muestran cromosomas no alineados en la placa metafásica (flechas). Estos cromosomas presentan marcaje para las proteínas del checkpoint de mitosis Mad1/Mad2. Hec1 y CENP-B marcan la región centromérica (el cinetocoro), y DAPI es una tinción específica para el ADN.
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{{Information |Description={{en|1=Metaphase cells depleted for CENP-E using RNAi, showing unaligned chromosomes (arrows) which show positive staining for checkpoint proteins Mad1/Mad2. CENP-B is a marker for the centromeric region, and DAPI labels the ADN
{{Information |Description={{en|1=Metaphase cells depleted for CENP-E using RNAi, showing unaligned chromosomes (arrows) which show positive staining for checkpoint proteins Mad1/Mad2. CENP-B is a marker for the centromeric region, and DAPI labels the ADN