PPP1R11

PPP1R11
Identifiers
Aliases	PPP1R11, HCG-V, HCGV, IPP3, TCTE5, TCTEX5, CFAP255, protein phosphatase 1 regulatory inhibitor subunit 11
External IDs	OMIM: 606670; MGI: 1923747; HomoloGene: 32520; GeneCards: PPP1R11; OMA:PPP1R11 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,070,333 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	37,262,633 bp
RNA expression pattern
	Top expressed in
	rectum; ; superior frontal gyrus; ; smooth muscle tissue; ; mucosa of transverse colon; ; granulocyte; ; duodenum; ; blood; ; epithelium of colon; ; primary visual cortex; ; body of stomach;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; interventricular septum; ; neural layer of retina; ; yolk sac; ; dentate gyrus of hippocampal formation granule cell; ; blastocyst; ; muscle of thigh; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein phosphatase inhibitor activity; protein binding; protein phosphatase 1 binding; protein serine/threonine phosphatase inhibitor activity; ubiquitin protein ligase activity; transferase activity;
Cellular component	cytoplasm; protein phosphatase type 1 complex; nucleus;
Biological process	negative regulation of phosphoprotein phosphatase activity; defense response to Gram-positive bacterium; protein ubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of protein dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	6992
	76497
ENSG00000234058; ENSG00000236560; ENSG00000237829; ENSG00000204619; ENSG00000237403;
	ENSG00000233314; ENSG00000206501; ENSG00000227720
	ENSMUSG00000036398
	O60927
	Q8K1L5
	NM_021959; NM_170781
	NM_029632
	NP_068778; NP_068778.1
	NP_083908
	Wikidata
View/Edit Human	View/Edit Mouse

Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene.^[5]^[6]^[7]

This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1.

The gene is located within the major histocompatibility complex class I region on chromosome 6.^[7]

References

^ ^a ^b ^c ENSG00000236560, ENSG00000237829, ENSG00000204619, ENSG00000237403, ENSG00000233314, ENSG00000206501, ENSG00000227720 GRCh38: Ensembl release 89: ENSG00000234058, ENSG00000236560, ENSG00000237829, ENSG00000204619, ENSG00000237403, ENSG00000233314, ENSG00000206501, ENSG00000227720 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036398 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang J, Zhang L, Zhao S, Lee EY (Dec 1998). "Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1". Biochemistry. 37 (47): 16728–34. doi:10.1021/bi981169g. PMID 9843442.
^ Giffon T, Lepourcelet M, Pichon L, Jezequel P, Bouric P, Carn G, Pontarotti P, Gall JY, David V (Oct 1996). "Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region". Immunogenetics. 44 (5): 331–9. doi:10.1007/BF02602777. PMID 8781118. S2CID 7130465.
^ ^a ^b "Entrez Gene: PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11".

Amadou C, Ribouchon MT, Mattei MG, et al. (1995). "Localization of new genes and markers to the distal part of the human major histocompatibility complex (MHC) region and comparison with the mouse: new insights into the evolution of mammalian genomes". Genomics. 26 (1): 9–20. doi:10.1016/0888-7543(95)80077-Y. PMID 7782091.
el Kahloun A, Chauvel B, Mauvieux V, et al. (1993). "Localization of seven new genes around the HLA-A locus". Hum. Mol. Genet. 2 (1): 55–60. doi:10.1093/hmg/2.1.55. PMID 8490624.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Lepourcelet M, Andrieux N, Giffon T, et al. (1997). "Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence". Genomics. 37 (3): 316–26. doi:10.1006/geno.1996.0566. PMID 8938444.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Lesage B, Beullens M, Pedelini L, et al. (2007). "A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3". Biochemistry. 46 (31): 8909–19. doi:10.1021/bi7003119. PMID 17630778.

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[refGRCh38Ensembl-1] ENSG00000236560, ENSG00000237829, ENSG00000204619, ENSG00000237403, ENSG00000233314, ENSG00000206501, ENSG00000227720 GRCh38: Ensembl release 89: ENSG00000234058, ENSG00000236560, ENSG00000237829, ENSG00000204619, ENSG00000237403, ENSG00000233314, ENSG00000206501, ENSG00000227720 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036398 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9843442-5] Zhang J, Zhang L, Zhao S, Lee EY (Dec 1998). "Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1". Biochemistry. 37 (47): 16728–34. doi:10.1021/bi981169g. PMID 9843442.

[pmid8781118-6] Giffon T, Lepourcelet M, Pichon L, Jezequel P, Bouric P, Carn G, Pontarotti P, Gall JY, David V (Oct 1996). "Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region". Immunogenetics. 44 (5): 331–9. doi:10.1007/BF02602777. PMID 8781118. S2CID 7130465.

[entrez-7] "Entrez Gene: PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11".

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[4]

[5]

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[7]

References

Further reading