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'{{Infobox drug | drug_name = Brincidofovir | IUPAC_name = | image = Brincidofovir.svg | alt = | caption = <!-- Clinical data --> | tradename = | Drugs.com = | MedlinePlus = | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_US = <!-- A / B / C / D / X --> | pregnancy_category= | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM --> | legal_US = Investigational:(ViaCNN) -- After just three doses of an experimental drug, Josh Hardy -- whose parents had to launch a media campaign to get him the medicine -- is sitting up, doing homework and playing board games with his brothers, his mother said. Just last week, Josh was so sick he could barely get out even a few words. He was in heart and kidney failure, and vomited blood several times an hour as his family held a vigil in the intensive care unit of a Memphis hospital. Josh received doses of the drug brincidofovir Wednesday, Saturday, and Tuesday, and tests showed the level of adenovirus in his blood went down from 250,000 copies per milliliter to 367 copies per milliter. "We expect it will be out of his system by Tuesday," his mother, Aimee Hardy, said Friday. "I'm beside myself with how effective this drug was so quickly." Mom's desperate plea to drug company Already they're seeing results of the waning virus in Josh's system. He no longer has bleeding in his stomach and intestines. Before receiving brincidofovir, Josh was fighting for his life. The adenovirus was ravaging his immune system, left vulnerable by treatment for cancer, and the only available antiviral drug to treat it wasn't working. In early February, Chimerix, the company that makes brincidofovir, refused to give Josh its experimental drug. But after reports by CNN and intense pressure from social media, Chimerix and the Food and Drug Administration came up with a plan to get the medicine to Josh and other patients who request it. | legal_status = | routes_of_administration = <!-- Pharmacokinetic data --> | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = <!-- Identifiers --> | CAS_number = 444805-28-1 | ATCvet = | ATC_prefix = <!-- 'none' if uncategorised --> | ATC_suffix = | PubChem = | DrugBank = | synonyms = CMX001; Cidofovir-HDP <!-- Chemical data --> | C=27 | H=52 | N=3 | O=7 | P=1 | molecular_weight = 561.70 g/mol }} '''Brincidofovir''' ('''CMX001''') is an experimental [[Antiviral drug|antiviral]] drug being [[drug development|developed]] by Chimerix for the treatment of [[cytomegalovirus]]. It also has activity against [[adenovirus]]es, [[BK virus]] and [[herpes simplex virus]]es.<ref>{{cite journal | doi = 10.1086/656717| pmid = 20923374| title = Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies| journal = The Journal of Infectious Diseases| volume = 202| issue = 10| pages = 1492| year = 2010| last1 = Quenelle| first1 = Debra C.| last2 = Lampert| first2 = Bernhardt| last3 = Collins| first3 = Deborah J.| last4 = Rice| first4 = Terri L.| last5 = Painter| first5 = George R.| last6 = Kern| first6 = Earl R.}}</ref><ref name= Chimerix >{{cite web | url = http://www.chimerix.com/therapeutic-programs/category/brincidofovir-cmx001 | publisher = Chimerix | title = Brincidofovir (CMX001)}}</ref> Brincidofovir is a [[prodrug]] of [[cidofovir]].<ref name= Chimerix/> ==References== {{Cnn news}} {{Antiinfective-drug-stub}} [[Category:Antivirals]] [[Category:Pyrimidones]] [[Category:Phosphonate esters]] [[Category:Prodrugs]]'