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'@@ -1,7 +1,8 @@ -The '''head-twitch(Mas conocido como el movimiento de los ratones response''' (HTR) is a rapid side-to-side head movement that occurs in mice and EdwinGaymer's and Cayden the [[serotonin]] [[5-HT2A receptor]] is activated.<ref>{{cite journal|last1=Nakagawasai|first1=O|last2=Arai|first2=Y|last3=Satoh|first3=SE|last4=Satoh|first4=N|last5=Neda|first5=M|last6=Hozumi|first6=M|last7=Oka|first7=R|last8=Hiraga|first8=H|last9=Tadano|first9=T|title=Monoamine Oxidase and Head-Twitch Response in Mice Mechanisms of α-Methylated Substrate Derivatives|journal=NeuroToxicology|date=January 2004|volume=25|issue=1-2|pages=223–232|doi=10.1016/S0161-813X(03)00101-3|pmid=14697897}}</ref> The [[prefrontal cortex]] may be the neuroanatomical locus mediating the HTR.<ref>{{cite journal|last1=Willins|first1=DL|last2=Meltzer|first2=HY|title=Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats.|journal=The Journal of pharmacology and experimental therapeutics|date=August 1997|volume=282|issue=2|pages=699-706|pmid=9262333}}</ref> Many serotonergic hallucinogens, including [[lysergic acid diethylamide]] (LSD), induce the head-twitch response, and so the HTR is used as a behavioral model of hallucinogen effects. However while there is generally a good correlation between compounds that induce head twitch in mice and compounds that are hallucinogenic in humans, it is unclear whether the head twitch response is primarily caused by [[5-HT2A receptor]]s, [[5-HT2C receptor]]s or both. Also, the effect can be non-specific, with head twitch responses also produced by some drugs that do not act through 5-HT₂ receptors, such as [[phencyclidine]], [[yohimbine]], [[atropine]] and [[cannabinoid receptor antagonist]]s. As well, compounds such as [[5-HTP]], [[fenfluramine]] and [[1-Methylpsilocin]] can also produce head twitch and do stimulate serotonin receptors, but are not hallucinogenic in humans. This means that while the head twitch response can be a useful indicator as to whether a compound is likely to display hallucinogenic activity in humans, the induction of a head twitch response does not necessarily mean that a compound will be hallucinogenic, and caution should be exercised when interpreting such results.<ref>{{cite journal|last1=Canal|first1=Clint E.|last2=Morgan|first2=Drake|title=Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model|journal=Drug Testing and Analysis|date=July 2012|volume=4|issue=7-8|pages=556–576|doi=10.1002/dta.1333|pmid=22517680}}</ref> +El "head-twitch(Mas conocido como el movimiento de cabeza hacia arriba de los ratones"(HTR)Es un rapido movimiento de cabeza hacia arriba donde levantas al jugador y lo mandas a la chucha, CaydenG0D y Cayden lo crearon. ==References== {{reflist}} LucianoTommoG0D And iLoro<3 [[Category:Medical terminology]] [[Category:Lysergic acid diethylamide]] + '