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[ 0 => '{{Use dmy dates|date=February 2020}}', 1 => '{{Infobox drug', 2 => '| Verifiedfields = changed', 3 => '| Watchedfields = changed', 4 => '| verifiedrevid = 456689148', 5 => '| drug_name = ', 6 => '| INN = ', 7 => '| type = <!-- empty -->', 8 => '| image = Amisulpride.svg', 9 => '| width = 250px', 10 => '| alt = ', 11 => '| image2 = Amisulpride-xtal-1990-ball-and-stick-model.png', 12 => '| width2 = 250px', 13 => '| alt2 = ', 14 => '| caption = ', 15 => '', 16 => '<!-- Clinical data -->', 17 => '| pronounce = ', 18 => '| tradename = Solian, Barhemsys, others', 19 => '| Drugs.com = {{drugs.com|international|amisulpride}}', 20 => '| MedlinePlus = ', 21 => '| licence_CA = <!-- Health Canada may use generic or brand name (generic name preferred) -->', 22 => '| licence_EU = <!-- EMA uses INN (or special INN_EMA) -->', 23 => '| DailyMedID = Amisulpride', 24 => '| licence_US = Barhemsys', 25 => '| pregnancy_AU = C', 26 => '| pregnancy_AU_comment = ', 27 => '| pregnancy_US = <!-- A / B / C / D / X / N -->', 28 => '| pregnancy_US_comment = ', 29 => '| pregnancy_category= ', 30 => '| dependency_liability = ', 31 => '| addiction_liability = ', 32 => '| routes_of_administration = [[Oral administration|By mouth]], [[intravenous therapy|intravenous]]', 33 => '| class = ', 34 => '| ATCvet = ', 35 => '| ATC_prefix = N05', 36 => '| ATC_suffix = AL05', 37 => '| ATC_supplemental = ', 38 => '', 39 => '<!-- Legal status -->', 40 => '| legal_AU = S4 ', 41 => '| legal_AU_comment = ', 42 => '| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F-->', 43 => '| legal_BR_comment = ', 44 => '| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->', 45 => '| legal_CA_comment = ', 46 => '| legal_DE = <!-- Anlage I, II, III or Unscheduled-->', 47 => '| legal_DE_comment = ', 48 => '| legal_NZ = <!-- Class A, B, C -->', 49 => '| legal_NZ_comment = ', 50 => '| legal_UK = POM', 51 => '| legal_UK_comment = <ref name="Amisulpride SmPC">{{cite web | title=Amisulpride 100 mg Tablets - Summary of Product Characteristics (SmPC) | website=(emc) | date=5 July 2019 | url=https://www.medicines.org.uk/emc/product/2726/smpc | access-date=26 February 2020}}</ref>', 52 => '| legal_US = Rx-only', 53 => '| legal_US_comment = ', 54 => '| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV-->', 55 => '| legal_UN_comment = ', 56 => '| legal_status = <!--For countries not listed above-->', 57 => '', 58 => '<!-- Pharmacokinetic data -->', 59 => '| bioavailability = 48%<ref name=Rosenzweig>{{ cite journal |author1=Rosenzweig, P. |author2=Canal, M. |author3=Patat, A. |author4=Bergougnan, L. |author5=Zieleniuk, I. |author6=Bianchetti, G. | title = A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers | journal = Human Psychopharmacology | volume = 17 | issue = 1 | year = 2002 | pages = 1–13 | pmid = 12404702 | doi = 10.1002/hup.320 }}</ref><ref name = SOLIAN>{{cite web|title=Solian tablets and solution product information |url=https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-01659-3|website=TGA eBusiness Services|publisher=Sanofi-Aventis Australia Pty Ltd|access-date=26 February 2020|format=PDF|date=27 September 2019}}</ref>', 60 => '| protein_bound = 16%<ref name = SOLIAN/>', 61 => '| metabolism = Hepatic (minimal; most excreted unchanged)<ref name = SOLIAN/>', 62 => '| metabolites = ', 63 => '| onset = ', 64 => '| elimination_half-life = 12 hours<ref name=Rosenzweig/>', 65 => '| duration_of_action = ', 66 => '| excretion = [[Kidney|Renal]]<ref name=Rosenzweig/> (23–46%),<ref name = BT>{{cite journal|author=Caccia, S|title=Biotransformation of Post-Clozapine Antipsychotics Pharmacological Implications|journal=Clinical Pharmacokinetics|doi=10.2165/00003088-200038050-00002|pmid=10843459|volume=38|issue=5|date=May 2000|pages=393–414}}</ref><ref name = Dys>{{cite journal|title=Amisulpride: A Review of its Clinical Potential in Dysthymia|author1=Noble, S |author2=Benfield, P |journal=CNS Drugs|volume=12|issue=6|date=December 1999|doi=10.2165/00023210-199912060-00005|pages=471–483}}</ref> [[Feces|Faecal]]<ref name = SOLIAN/>', 67 => '', 68 => '<!-- Identifiers -->', 69 => '| CAS_number_Ref = {{cascite|changed|??}}', 70 => '| CAS_number = 71675-85-9', 71 => '| CAS_supplemental = ', 72 => '| PubChem = 2159', 73 => '| IUPHAR_ligand = 963', 74 => '| DrugBank_Ref = {{drugbankcite|correct|drugbank}}', 75 => '| DrugBank = DB06288', 76 => '| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}', 77 => '| ChemSpiderID = 2074', 78 => '| UNII_Ref = {{fdacite|correct|FDA}}', 79 => '| UNII = 8110R61I4U', 80 => '| KEGG_Ref = {{keggcite|correct|kegg}}', 81 => '| KEGG = D07310', 82 => '| ChEBI_Ref = {{ebicite|changed|EBI}} ', 83 => '| ChEBI = 64045', 84 => '| ChEMBL_Ref = {{ebicite|correct|EBI}}', 85 => '| ChEMBL = 243712', 86 => '| NIAID_ChemDB = ', 87 => '| PDB_ligand = ', 88 => '| synonyms = APD421', 89 => '', 90 => '<!-- Chemical and physical data -->', 91 => '| IUPAC_name = 4-amino-''N''-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide', 92 => '| chemical_formula = ', 93 => '| C=17 | H=27 | N=3 | O=4 | S=1 ', 94 => '| molecular_weight = 369.48 g/mol', 95 => '| SMILES = O=S(=O)(c1cc(c(OC)cc1N)C(=O)NCC2N(CC)CCC2)CC', 96 => '| Jmol = ', 97 => '| StdInChI_Ref = {{stdinchicite|correct|chemspider}}', 98 => '| StdInChI = 1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)', 99 => '| StdInChI_comment = ', 100 => '| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}', 101 => '| StdInChIKey = NTJOBXMMWNYJFB-UHFFFAOYSA-N', 102 => '| density = ', 103 => '| density_notes = ', 104 => '| melting_point = ', 105 => '| melting_high = ', 106 => '| melting_notes = ', 107 => '| boiling_point = ', 108 => '| boiling_notes = ', 109 => '| solubility = ', 110 => '| sol_units = ', 111 => '| specific_rotation = ', 112 => '}}', 113 => '', 114 => ''''Amisulpride''' is an [[antiemetic]] and [[antipsychotic]] medication used at lower doses intravenously to prevent and treat [[postoperative nausea and vomiting]]; and at higher doses orally and intramuscularly{{mcn|date=February 2020}} to treat [[schizophrenia]] and [[psychosis|acute psychotic episodes]]. It is sold under the brandnames '''Barhemsys'''<ref name="Barhemsys label" /> (as an antiemetic) and Solian, Socian, Deniban and others (as an antipsychotic).<ref name="SOLIAN"/> It is also used to treat [[dysthymia]].<ref name = Itdys>{{cite journal|title=The substituted benzamides and their clinical potential on dysthymia and on the negative symptoms of schizophrenia|vauthors=Pani L, Gessa GL |journal=Molecular Psychiatry|volume=7|issue=3|pages=247–53|pmid=11920152|year=2002|doi=10.1038/sj.mp.4001040 | doi-access=free }}</ref> ', 115 => '', 116 => 'It is usually classed with the [[atypical antipsychotics]]. Chemically it is a [[benzamide]] and like other benzamide antipsychotics, such as [[sulpiride]], it is associated with a high risk of elevating blood levels of the lactation hormone, [[prolactin]] (thereby potentially causing [[amenorrhoea|the absence of the menstrual cycle]], breast enlargement, even in males, [[galactorrhoea|breast milk secretion not related to breastfeeding]], impaired fertility, [[impotence]], breast pain, ''etc.''), and a low risk, relative to the [[typical antipsychotics]], of causing [[extrapyramidal effect|movement disorders]].<ref name="AMH"/><ref name="Lancet"/><ref name="MD"/> It has also been found to be modestly more effective in treating schizophrenia than the typical antipsychotics.<ref name="Lancet"/>', 117 => '', 118 => 'Amisulpride is approved for use in the United States in adults for the prevention of [[postoperative nausea and vomiting]] (PONV), either alone or in combination with an [[antiemetic]] of a different class; and to treat PONV in those who have received antiemetic prophylaxis with an agent of a different class or have not received prophylaxis.<ref name="Barhemsys label">{{cite web | title=Barhemsys (amisulpride) injection, for intravenous use | url=https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209510s000lbl.pdf | publisher=U.S. [[Food and Drug Administration]] (FDA) | date=February 2020 | access-date=26 February 2020}}</ref>', 119 => '', 120 => 'Amisulpride is believed to work by blocking, or antagonizing, the [[dopamine D2 receptor|dopamine D₂ receptor]], reducing its signalling. The effectiveness of amisulpride in treating dysthymia and the [[negative symptoms]] of schizophrenia is believed to stem from its blockade of the [[presynaptic]] dopamine D₂ receptors. These presynaptic receptors regulate the release of [[dopamine]] into the [[synapse]], so by blocking them amisulpride increases dopamine concentrations in the synapse. This increased dopamine concentration is theorized to act on [[dopamine D1 receptor|dopamine D₁ receptors]] to relieve depressive symptoms (in dysthymia) and the negative symptoms of schizophrenia.<ref name="Itdys"/>', 121 => '', 122 => 'It was introduced by [[Sanofi-Aventis]] in the 1990s. Its patent expired by 2008, and generic formulations became available.<ref>{{cite journal|author1=De Silva, V |author2=Hanwella, R |title=Pharmaceutical patents and the quality of mental healthcare in low- and middle-income countries|journal=The Psychiatrist|volume=32|issue=4|pages=121–23|doi=10.1192/pb.bp.107.015651|date=April 2008|doi-access=free }}</ref> It is marketed in all English-speaking countries except for Canada and the United States.<ref name = "MD">{{Cite web| title = Amisulpride: Martindale: The Complete Drug Reference| access-date = 5 August 2017| url = https://www.medicinescomplete.com/mc/martindale/current/1759-d.htm | website = MedicineComplete | publisher = Pharmaceutical Press | date = June 2017 | editor = Brayfield, A}}</ref> A New York City based company, LB Pharmaceuticals, has announced the ongoing development of LB-102, also known as N-methyl amisulpride, an antipsychotic specifically targeting the United States.<ref>{{cite web|url=http://lbpharma.us/pipeline/|title=Pipeline|website=LB Pharmaceuticals|access-date=2019-08-29}}</ref><ref>{{cite web | title=About Us | website=LB Pharmaceuticals | url=http://lbpharma.us/about-us/ | access-date=26 February 2020}}</ref> A poster presentation at European Neuropsychopharmacology<ref>{{cite web | url=http://lbpharma.us/wp-content/uploads/2018/03/ECNP-2017-FINAL.jpg | title=Data presented at 2017 ECNP meeting (European Neuropsychopharmacology, 2017, 27 (S4), S922-S923) |website=LB Pharmaceuticals | access-date=26 February 2020}}</ref> seems to suggest that this version of amisulpride, known as LB-102 displays the same binding to D2, D3 and 5HT7 that amisulpride does.<ref>{{Cite web|url=http://lbpharma.us/wp-content/uploads/2019/09/LB-102-clinical-translation-Final-final-08.26.19-1.pdf|title=Building a translational bridge from animals to man for clinical candidate LB-102, a next-generation benzamide antipsychotic (P.101) |website=LB Pharmaceuticals|access-date=2019-08-29}}</ref><ref>{{cite journal | vauthors=Grattan V, Vaino AR, Prensky Z, Hixon MS | title=Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D2 and D3, while R Enantiomers Engage 5-HT7 | journal=ACS Omega | volume=4 | issue=9 | date=August 2019 | issn=2470-1343 | doi=10.1021/acsomega.9b02144 | pages=14151–4 | doi-access=free | pmid=31497735 | pmc=6714530 }}</ref>', 123 => '', 124 => '==Medical uses==', 125 => '', 126 => '===Schizophrenia===', 127 => 'In a 2013 study in a comparison of 15 antipsychotic drugs in effectiveness in treating schizophrenic symptoms, amisulpride was ranked second and demonstrated high effectiveness. 11% more effective than [[olanzapine]] (3rd), 32-35% more effective than [[haloperidol]], [[quetiapine]], and [[aripiprazole]], and 25% less effective than [[clozapine]] (1st).<ref name="Lancet"/> Although according to other studies it appears to have comparable efficacy to [[olanzapine]] in the treatment of schizophrenia.<ref>{{cite journal| author = Komossa, K |author2=Rummel-Kluge, C |author3=Hunger, H |author4=Schmid, F |author5=Schwarz, S|author6=Silveira da Mota Neto, JI |author7=Kissling, W |author8=Leucht, S | date=January 2010 | title = Amisulpride versus other atypical antipsychotics for schizophrenia| journal = The Cochrane Database of Systematic Reviews| volume = | issue = 1| pages = CD006624| pmid = 20091599| doi = 10.1002/14651858.CD006624.pub2 | pmc=4164462}}</ref><ref>{{cite journal|author1=Leucht, S |author2=Corves, C |author3=Arbter, D |author4=Engel, RR |author5=Li, C |author6=Davis, JM | date=January 2009 | title = Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis| journal = Lancet| volume = 373| issue = 9657| pages = 31–41| pmid = 19058842| doi = 10.1016/S0140-6736(08)61764-X}}</ref> Amisulpride augmentation, similarly to [[sulpiride]] augmentation, has been considered a viable treatment option (although this is based on low-quality evidence) in [[clozapine]]-resistant cases of schizophrenia.<ref>{{cite journal|title=Current perspectives in the treatment of resistant schizophrenia|author1=Solanki, RK |author2=Sing, P |author3=Munshi, D |journal=Indian Journal of Psychiatry|volume=51|issue=4|date=Oct–Dec 2009|doi=10.4103/0019-5545.58289|pmid=20048449|pmc=2802371|pages=254–60}}</ref><ref>{{cite journal|title=Augmentation Strategies of Clozapine With Antipsychotics in the Treatment of Ultraresistant Schizophrenia|author1=Mouaffak, F |author2=Tranulis, C |author3=Gourevitch, R |author4=Poirier, MF |author5=Douki, S |author6=Olié, JP |author7=Lôo, H |author8=Gourion, D |journal=Clinical Neuropharmacology|volume=29|issue=1|pages=28–33|pmid=16518132|doi=10.1097/00002826-200601000-00009|year=2006 }}</ref> Another recent study concluded that amisulpride is an appropriate first-line treatment for the management of acute psychosis.<ref>{{ cite journal |author1=Nuss, P. |author2=Hummer, M. |author3=Tessier, C. | title = The use of amisulpride in the treatment of acute psychosis | journal = Therapeutics and Clinical Risk Management | volume = 3 | issue = 1 | year = 2007 | pages = 3–11 | pmid = 18360610 | pmc = 1936283 | doi=10.2147/tcrm.2007.3.1.3}}</ref>', 128 => '', 129 => '==Contraindications==', 130 => 'Amisulpride's use is contraindicated in the following disease states<ref name = SOLIAN/><ref name = BNF/><ref name = AMH/>', 131 => '', 132 => '* [[Pheochromocytoma]]', 133 => '* Concomitant prolactin-dependent tumours e.g. [[prolactinoma]], [[breast cancer]]', 134 => '* Movement disorders (e.g. [[Parkinson's disease]] and [[dementia with Lewy bodies]])', 135 => '* Lactation', 136 => '* Children before the onset of puberty', 137 => '', 138 => 'Neither is it recommended to use amisulpride in patients with hypersensitivities to amisulpride or the excipients found in its dosage form.<ref name = SOLIAN/>', 139 => '', 140 => '==Adverse effects==', 141 => ';Very Common (≥10% incidence)<ref name="Amisulpride SmPC" />', 142 => '* [[Extrapyramidal side effects]] (EPS; including [[dystonia]], tremor, [[akathisia]], [[parkinsonism]]). Produces a moderate degree of EPS; more than aripiprazole (not ''significantly'', however), clozapine, iloperidone (not ''significantly''), olanzapine (not ''significantly''), quetiapine (not ''significantly'') and sertindole; less than chlorpromazine (not ''significantly''), haloperidol, lurasidone (not ''significantly''), paliperidone (not ''significantly''), risperidone (not ''significantly''), ziprasidone (not ''significantly'') and zotepine (not ''significantly'').<ref name = Lancet/>', 143 => '', 144 => ';Common (≥1%, <10% incidence)<ref name="Amisulpride SmPC" /><ref name = SOLIAN/><ref name = "DRUGDEX">Truven Health Analytics, Inc. DRUGDEX System (Internet) [cited 2013 Sep 19]. Greenwood Village, CO: Thomsen Healthcare; 2013.</ref><ref name="BNF">{{cite book | isbn = 978-0-85711-084-8 | title = British National Formulary (BNF) | last1 = Joint Formulary Committee | year = 2013 | publisher = Pharmaceutical Press | location = London, UK | edition = 65 | pages = | url-access = registration | url = https://archive.org/details/bnf65britishnati0000unse }}</ref><ref name="AMH">{{cite book | editor = Rossi, S | isbn = 978-0-9805790-9-3 | title = Australian Medicines Handbook | place = Adelaide | publisher = The Australian Medicines Handbook Unit Trust | year = 2013 | edition = 2013 }}</ref>', 145 => '{{div col|colwidth=22em}}', 146 => '* [[Insomnia]]', 147 => '* [[Hypersalivation]]', 148 => '* Nausea', 149 => '* Headache', 150 => '* [[Hyperactivity]]', 151 => '* Anxiety', 152 => '* Vomiting', 153 => '{{div col end}}', 154 => '* [[Hyperprolactinaemia]] (which can lead to galactorrhoea, breast enlargement and tenderness, sexual dysfunction, etc.)', 155 => '* Weight gain (produces less weight gain than chlorpromazine, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, zotepine and more (although not statistically significantly) weight gain than haloperidol, lurasidone, ziprasidone and approximately as much weight gain as aripiprazole and asenapine)<ref name = Lancet/>', 156 => '* [[Anticholinergic]] side effects (although it does not bind to the muscarinic acetylcholine receptors and hence these side effects are usually quite mild) such as', 157 => ':- constipation', 158 => ':- dry mouth', 159 => ':- disorder of accommodation', 160 => ':- Blurred vision', 161 => ';Rare (<1% incidence)<ref name="Amisulpride SmPC" /><ref name = SOLIAN/><ref name = "DRUGDEX" /><ref name = "BNF" /><ref name = "AMH" />', 162 => '{{div col|colwidth=22em}}', 163 => '* [[Hyponatraemia]]', 164 => '* [[Bradycardia]]', 165 => '* [[Hypotension]]', 166 => '* [[Palpitations]]', 167 => '* [[Urticaria]]', 168 => '* [[Seizures]]', 169 => '* [[Mania]]', 170 => '* [[Oculogyric crisis]]', 171 => '* [[Tardive dyskinesia]]', 172 => '{{div col end}}', 173 => '* Blood [[dyscrasia]]s such as [[leucopenia]], [[neutropenia]] and [[agranulocytosis]]', 174 => '* [[QT interval]] prolongation (in a recent meta-analysis of the safety and efficacy of 15 antipsychotic drugs amisulpride was found to have the 2nd highest effect size for causing QT interval prolongation<ref name = "Lancet">{{cite journal', 175 => ' |author1=Leucht, S |author2=Cipriani, A |author3=Spineli, L |author4=Mavridis, D |author5=Orey, D |author6=Richter, F |author7=Samara, M |author8=Barbui, C |author9=Engel, RR |author10=Geddes, JR |author11=Kissling, W |author12=Stapf, MP |author13=Lässig, B |author14=Salanti, G |author15=Davis, JM | date=September 2013 | title = Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis', 176 => ' | journal = Lancet', 177 => ' | volume = 382', 178 => ' | issue = 9896', 179 => ' | pages = 951–962', 180 => ' | pmid = 23810019', 181 => ' | doi = 10.1016/S0140-6736(13)60733-3', 182 => '}}</ref>)', 183 => '', 184 => 'Hyperprolactinaemia results from antagonism of the [[D2 receptor|D₂]] receptors located on the lactotrophic cells found in the [[anterior pituitary gland]]. Amisulpride has a high propensity for elevating plasma [[prolactin]] levels as a result of its poor [[blood-brain barrier]] penetrability and hence the resulting greater ratio of peripheral D₂ occupancy to central D₂ occupancy. This means that to achieve the sufficient occupancy (~60–80%<ref name="GG">{{cite book | isbn = 978-0-07-162442-8 | title = Goodman and Gilman's The Pharmacological Basis of Therapeutics | edition = 12th |author1=Brunton, L |author2=Chabner, B |author3=Knollman, B | year = 2010 | publisher = McGraw-Hill Professional | location = New York | title-link = Goodman and Gilman's The Pharmacological Basis of Therapeutics }}</ref>) of the central D₂ receptors in order to elicit its therapeutic effects a dose must be given that is enough to saturate peripheral D₂ receptors including those in the anterior pituitary.<ref name=mckeage>{{cite journal', 185 => ' |author1=McKeage, K |author2=Plosker, GL | title = Amisulpride: a review of its use in the management of schizophrenia', 186 => ' | journal = CNS Drugs', 187 => ' | volume = 18', 188 => ' | issue = 13', 189 => ' | pages = 933–956', 190 => ' | doi = 10.2165/00023210-200418130-00007', 191 => ' | pmid = 15521794', 192 => ' | issn = 1172-7047', 193 => ' | year=2004', 194 => '}}</ref><ref>{{cite journal', 195 => ' |author1=Natesan, S |author2=Reckless, GE |author3=Barlow, KB |author4=Nobrega, JN |author5=Kapur, S | date=October 2008 | title = Amisulpride the 'atypical' atypical antipsychotic — Comparison to haloperidol, risperidone and clozapine', 196 => ' | journal = Schizophrenia Research', 197 => ' | volume = 105', 198 => ' | issue = 1–3', 199 => ' | pages = 224–235', 200 => ' | pmid = 18710798', 201 => ' | doi = 10.1016/j.schres.2008.07.005', 202 => '}}</ref>', 203 => '* [[Somnolence]]. It produces minimal sedation due to its absence of cholinergic, histaminergic and alpha adrenergic receptor antagonism. It is one of the least sedating antipsychotics.<ref name = Lancet/>', 204 => '', 205 => '===Discontinuation===', 206 => 'The [[British National Formulary]] recommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse.<ref name="Group 2009 192">{{cite book |editor1-first=BMJ | editor = Joint Formulary Committee | title = British National Formulary | edition = 57 | date = March 2009 |publisher=Royal Pharmaceutical Society of Great Britain |location=United Kingdom |isbn=978-0-85369-845-6 |page=192 |chapter=4.2.1 |quote=Withdrawal of antipsychotic drugs after long-term therapy should always be gradual and closely monitored to avoid the risk of acute withdrawal syndromes or rapid relapse.}}</ref> Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite.<ref name=Had2004>{{cite book |last1=Haddad |first1=Peter |last2=Haddad |first2=Peter M. |last3=Dursun |first3=Serdar |last4=Deakin |first4=Bill |title=Adverse Syndromes and Psychiatric Drugs: A Clinical Guide |date=2004 |publisher=OUP Oxford |isbn=9780198527480 |page=207–216 |url=https://books.google.ca/books?id=CWR7DwAAQBAJ&pg=PA207 |language=en}}</ref> Other symptoms may include restlessness, increased sweating, and trouble sleeping.<ref name=Had2004/> Less commonly there may be a felling of the world spinning, numbness, or muscle pains.<ref name=Had2004/> Symptoms generally resolve after a short period of time.<ref name=Had2004/>', 207 => '', 208 => 'There is tentative evidence that discontinuation of antipsychotics can result in psychosis.<ref>{{cite journal | vauthors = Moncrieff J | title = Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal-related relapse | journal = Acta Psychiatrica Scandinavica | volume = 114 | issue = 1 | pages = 3–13 | date = July 2006 | pmid = 16774655 | doi = 10.1111/j.1600-0447.2006.00787.x }}</ref> It may also result in reoccurrence of the condition that is being treated.<ref>{{cite book |last1=Sacchetti |first1=Emilio |last2=Vita |first2=Antonio |last3=Siracusano |first3=Alberto |last4=Fleischhacker |first4=Wolfgang |title=Adherence to Antipsychotics in Schizophrenia |date=2013 |publisher=Springer Science & Business Media |isbn=9788847026797 |page=85 |url=https://books.google.ca/books?id=odE-AgAAQBAJ&pg=PA85 |language=en}}</ref> Rarely tardive dyskinesia can occur when the medication is stopped.<ref name=Had2004/>', 209 => '', 210 => '===Overdose===', 211 => '[[Torsades de pointes]] is common in overdose.<ref>{{cite journal|title=Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes|journal=Journal of Clinical Psychopharmacology|date=August 2010|volume=30|issue=4|pages=391–395|doi=10.1097/JCP.0b013e3181e5c14c|pmid=20531221|author1=Isbister, GK |author2=Balit, CR |author3=Macleod, D |author4=Duffull, SB }}</ref><ref>{{cite journal|title=Prediction of Torsade de Pointes From the QT Interval: Analysis of a Case Series of Amisulpride Overdoses|journal=Clinical Pharmacology & Therapeutics|date=August 2011|volume=90|issue=2|pages=243–245|doi=10.1038/clpt.2011.107|pmid=21716272|author1=Joy, JP |author2=Coulter, CV |author3=Duffull, SB |author4=Isbister, GK }}</ref> Amisulpride is moderately dangerous in overdose (with the [[tricyclic antidepressants|TCAs]] being very dangerous and the [[Selective serotonin reuptake inhibitors|SSRIs]] being modestly dangerous).<ref name = Maudsley/><ref>{{cite journal', 212 => ' |author1=Levine, M |author2=Ruha, AM | date=July 2012 | title = Overdose of atypical antipsychotics: clinical presentation, mechanisms of toxicity and management', 213 => ' | journal = CNS Drugs', 214 => ' | volume = 26', 215 => ' | issue = 7', 216 => ' | pages = 601–611', 217 => ' | doi = 10.2165/11631640-000000000-00000', 218 => ' | pmid = 22668123', 219 => ' }}</ref>', 220 => '', 221 => '===Interactions===', 222 => 'Amisulpride should not be used in conjunction with drugs that prolong the QT interval (such as [[citalopram]], [[venlafaxine]], [[bupropion]], [[clozapine]], [[tricyclic antidepressants]], [[sertindole]], [[ziprasidone]], etc.),<ref name="Maudsley">{{cite book | isbn = 978-0-47-097948-8 | title = Maudsley Prescribing Guidelines in Psychiatry | edition = 11th |author1=Taylor, D |author2=Paton, C |author3=Shitij, K | date = 2012 | publisher = Wiley-Blackwell | location = West Sussex }}</ref> reduce heart rate and those that can induce hypokalaemia. Likewise it is imprudent to combine antipsychotics due to the additive risk for [[tardive dyskinesia]] and [[neuroleptic malignant syndrome]].<ref name = Maudsley />', 223 => '', 224 => '==Pharmacology==', 225 => '', 226 => '===Pharmacodynamics===', 227 => '{{See also|Atypical antipsychotic#Pharmacodynamics|Antipsychotic#Comparison of medications}}', 228 => '{| class="wikitable floatright" style="font-size:small;"', 229 => '|+ Amisulpride<ref name="PDSP">{{cite web | title = PDSP K_i Database | website = Psychoactive Drug Screening Program (PDSP) | author1 = Roth, BL | author2 = Driscol, J | publisher = University of North Carolina at Chapel Hill and the United States National Institute of Mental Health | access-date = 14 August 2017 | url = https://pdsp.unc.edu/databases/pdsp.php?knowID=0&kiKey=&receptorDD=&receptor=&speciesDD=&species=&sourcesDD=&source=&hotLigandDD=&hotLigand=&testLigandDD=&testFreeRadio=testFreeRadio&testLigand=amisulpride&referenceDD=&reference=&KiGreater=&KiLess=&kiAllRadio=all&doQuery=Submit+Query}}</ref><ref name="pmid19337725" />', 230 => '|-', 231 => '! Site !! K_i (nM) !! Species !! Ref', 232 => '|-', 233 => '| [[5-HT1A receptor|5-HT_1A]] || >10,000 || Human || <ref name="pmid19337725">{{cite journal | vauthors = Abbas AI, Hedlund PB, Huang XP, Tran TB, Meltzer HY, Roth BL | title = Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo | journal = Psychopharmacology | volume = 205 | issue = 1 | pages = 119–28 | year = 2009 | pmid = 19337725 | pmc = 2821721 | doi = 10.1007/s00213-009-1521-8 | url = }}</ref>', 234 => '|-', 235 => '| [[5-HT1B receptor|5-HT_1B]] || 1,744 || Human || <ref name="pmid19337725" />', 236 => '|-', 237 => '| [[5-HT1D receptor|5-HT_1D]] || 1,341 || Human || <ref name="pmid19337725" />', 238 => '|-', 239 => '| [[5-HT1E receptor|5-HT_1E]] || >10,000 || Human || <ref name="pmid19337725" />', 240 => '|-', 241 => '| [[5-HT2A receptor|5-HT_2A]] || 8,304 || Human || <ref name="pmid19337725" />', 242 => '|-', 243 => '| [[5-HT2B receptor|5-HT_2B]] || 13 || Human || <ref name="pmid19337725" />', 244 => '|-', 245 => '| [[5-HT2C receptor|5-HT_2C]] || >10,000 || Human || <ref name="pmid19337725" />', 246 => '|-', 247 => '| [[5-HT3 receptor|5-HT₃]] || >10,000 || Human || <ref name="pmid19337725" />', 248 => '|-', 249 => '| [[5-HT5A receptor|5-HT_5A]] || >10,000 || Human || <ref name="pmid19337725" />', 250 => '|-', 251 => '| [[5-HT6 receptor|5-HT₆]] || 4,154 || Human || <ref name="pmid19337725" />', 252 => '|-', 253 => '| [[5-HT7 receptor|5-HT₇]] || 11.5 || Human || <ref name="pmid19337725"/>', 254 => '|-', 255 => '| [[Alpha-1A adrenergic receptor|α_1A]] || >10,000 || Human || <ref name="pmid19337725" />', 256 => '|-', 257 => '| [[Alpha-1B adrenergic receptor|α_1B]] || >10,000 || Human || <ref name="pmid19337725" />', 258 => '|-', 259 => '| [[Alpha-1D adrenergic receptor|α_1D]] || >10,000 || Human || <ref name="pmid19337725" />', 260 => '|-', 261 => '| [[Alpha-2A adrenergic receptor|α_2A]] || 1,114 || Human || <ref name="pmid19337725" />', 262 => '|-', 263 => '| [[Alpha-2C adrenergic receptor|α_2C]] || 1,540 || Human || <ref name="pmid19337725" />', 264 => '|-', 265 => '| [[Beta-1 adrenergic receptor|β₁]] || >10,000 || Human || <ref name="pmid19337725" />', 266 => '|-', 267 => '| [[Beta-2 adrenergic receptor|β₂]] || >10,000 || Human || <ref name="pmid19337725" />', 268 => '|-', 269 => '| [[Beta-3 adrenergic receptor|β₃]] || >10,000 || Human || <ref name="pmid19337725" />', 270 => '|-', 271 => '| [[D1 receptor|D₁]] || >10,000 || Human || <ref name="pmid19337725" />', 272 => '|-', 273 => '| [[D2 receptor|D₂]] || 3.0 || Human || <ref name="pmid19337725" />', 274 => '|-', 275 => '| [[D3 receptor|D₃]] || 3.5 || Rat || <ref name="pmid19337725" />', 276 => '|-', 277 => '| [[D4 receptor|D₄]] || 2,369 || Human || <ref name="pmid19337725" />', 278 => '|-', 279 => '| [[D5 receptor|D₅]] || >10,000 || Human || <ref name="pmid19337725" />', 280 => '|-', 281 => '| [[H1 receptor|H₁]] || >10,000 || Human || <ref name="pmid19337725" />', 282 => '|-', 283 => '| [[H2 receptor|H₂]] || >10,000 || Human || <ref name="pmid19337725" />', 284 => '|-', 285 => '| [[H4 receptor|H₄]] || >10,000 || Human || <ref name="pmid19337725" />', 286 => '|-', 287 => '| [[M1 receptor|M₁]] || >10,000 || Human || <ref name="pmid19337725" />', 288 => '|-', 289 => '| [[M2 receptor|M₂]] || >10,000 || Human || <ref name="pmid19337725" />', 290 => '|-', 291 => '| [[M3 receptor|M₃]] || >10,000 || Human || <ref name="pmid19337725" />', 292 => '|-', 293 => '| [[M4 receptor|M₄]] || >10,000 || Human || <ref name="pmid19337725" />', 294 => '|-', 295 => '| [[M5 receptor|M₅]] || >10,000 || Human || <ref name="pmid19337725" />', 296 => '|-', 297 => '| [[Sigma-1 receptor|σ₁]] || >10,000 || Rat || <ref name="pmid19337725" />', 298 => '|-', 299 => '| [[Sigma-2 receptor|σ₂]] || >10,000 || Rat || <ref name="pmid19337725" />', 300 => '|-', 301 => '| {{abbrlink|MOR|μ-Opioid receptor}} || >10,000 || Human || <ref name="pmid19337725" />', 302 => '|-', 303 => '| {{abbrlink|DOR|δ-Opioid receptor}} || >10,000 || Human || <ref name="pmid19337725" />', 304 => '|-', 305 => '| {{abbrlink|KOR|κ-Opioid receptor}} || >10,000 || Human || <ref name="pmid19337725" />', 306 => '|-', 307 => '| {{abbrlink|GHB^High|High-affinity γ-hydroxybutyric acid receptor}} || 50 ({{abbrlink|IC₅₀|Half-maximal inhibitory concentration}}) || Rat || <ref name="pmid7914168" />', 308 => '|-', 309 => '| [[NMDA receptor|{{abbr|NMDA|N-Methyl-D-aspartate receptor}}<br />({{abbr|PCP|Phencyclidine site}})]] || >10,000 || Rat || <ref name="pmid8996185">{{cite journal | vauthors = Schoemaker H, Claustre Y, Fage D, Rouquier L, Chergui K, Curet O, Oblin A, Gonon F, Carter C, Benavides J, Scatton B | title = Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity | journal = J. Pharmacol. Exp. Ther. | volume = 280 | issue = 1 | pages = 83–97 | year = 1997 | pmid = 8996185 | doi = | url = }}</ref>', 310 => '|-', 311 => '| {{abbrlink|SERT|Serotonin transporter}} || >10,000 || Human || <ref name="pmid19337725" />', 312 => '|-', 313 => '| {{abbrlink|NET|Norepinephrine transporter}} || >10,000 || Human || <ref name="pmid19337725" />', 314 => '|-', 315 => '| {{abbrlink|DAT|Dopamine transporter}} || >10,000 || Human || <ref name="pmid19337725" />', 316 => '|- class="sortbottom"', 317 => '| colspan="4" style="width: 1px;" | Values are K_i (nM). The smaller the value, the more strongly the drug binds to the site.', 318 => '|}', 319 => '', 320 => 'Amisulpride functions primarily as a [[dopamine receptor|dopamine]] [[D2 receptor|D₂]] and [[D3 receptor|D₃ receptor]] [[receptor antagonist|antagonist]]. It has high [[affinity (pharmacology)|affinity]] for these receptors with [[dissociation constant]]s of 3.0 and 3.5&nbsp;nM, respectively.<ref name="pmid19337725" /> Although standard doses used to treat [[psychosis]] inhibit [[dopaminergic]] [[neurotransmission]], low doses preferentially block inhibitory [[presynaptic]] [[autoreceptor]]s. This results in a facilitation of dopamine activity, and for this reason, low-dose amisulpride has also been used to treat [[dysthymia]].<ref name = SOLIAN/>', 321 => '', 322 => 'Amisulpride and its relatives [[sulpiride]], [[levosulpiride]], and [[sultopride]] have been shown to bind to the high-affinity [[GHB receptor]] at concentrations that are therapeutically relevant ({{abbrlink|IC₅₀|Half-maximal inhibitory concentration}} = 50&nbsp;nM for amisulpride).<ref name="pmid7914168">{{ cite journal |author1=Maitre, M. |author2=Ratomponirina, C. |author3=Gobaille, S. |author4=Hodé, Y. |author5=Hechler, V. | title = Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics | journal = European Journal of Pharmacology | volume = 256 | issue = 2 | pages = 211–214 |date=Apr 1994 | pmid = 7914168 | doi = 10.1016/0014-2999(94)90248-8 }}</ref>', 323 => '', 324 => 'Amisulpride, [[sultopride]] and [[sulpiride]] respectively present decreasing [[in vitro]] affinities for the [[Dopamine receptor D2|D2 receptor]] (IC50 = 27, 120 and 181 nM) and the D3 receptor (IC50 = 3.6, 4.8 and 17.5 nM).<ref>{{Citation|last=Blomme|first=Audrey|title=Amisulpride, Sultopride and Sulpiride: Comparison of Conformational and Physico-Chemical Properties|date=2000|work=Molecular Modeling and Prediction of Bioactivity|pages=404–405|publisher=Springer US|language=en|doi=10.1007/978-1-4615-4141-7_97|isbn=9781461368571|last2=Conraux|first2=Laurence|last3=Poirier|first3=Philippe|last4=Olivier|first4=Anne|last5=Koenig|first5=Jean-Jacques|last6=Sevrin|first6=Mireille|last7=Durant|first7=François|last8=George|first8=Pascal}}</ref>', 325 => '', 326 => 'Though it was long widely assumed that dopaminergic modulation is solely responsible for the respective [[antidepressant]] and [[antipsychotic]] properties of amisulpride, it was subsequently found that the drug also acts as a potent antagonist of the [[serotonin receptor|serotonin]] [[5-HT7 receptor|5-HT₇ receptor]] (K_i = 11.5&nbsp;nM).<ref name="pmid19337725" /> Several of the other atypical antipsychotics such as [[risperidone]] and [[ziprasidone]] are potent antagonists at the 5-HT₇ receptor as well, and selective antagonists of the receptor show antidepressant properties themselves. To characterize the role of the 5-HT₇ receptor in the antidepressant effects of amisulpride, a study prepared 5-HT₇ receptor knockout mice.<ref name="pmid19337725"/> The study found that in two widely used rodent models of depression, the tail suspension test, and the forced swim test, those mice did not exhibit an antidepressant response upon treatment with amisulpride.<ref name="pmid19337725"/> These results suggest that 5-HT₇ receptor antagonism mediates the antidepressant effects of amisulpride.<ref name="pmid19337725"/>', 327 => '', 328 => 'Amisulpride also appears to bind with high affinity to the serotonin [[5-HT2B receptor|5-HT_2B receptor]] (K_i = 13&nbsp;nM), where it acts as an antagonist.<ref name="pmid19337725" /> The clinical implications of this, if any, are unclear.<ref name="pmid19337725" /> In any case, there is no evidence that this action mediates any of the therapeutic effects of amisulpride.<ref name="pmid19337725" />', 329 => '', 330 => '==Society and culture==', 331 => '', 332 => '===Brand names===', 333 => 'Brand names include: Amazeo, Amipride <small>([[Australia|AU]])</small>, Amival, Solian <small>([[Australia|AU]], [[Ireland|IE]], [[Russian Federation|RU]], [[United Kingdom|UK]], [[South Africa|ZA]])</small>, Soltus, Sulpitac <small>([[India|IN]])</small>, Sulprix <small>([[Australia|AU]])</small>, Midora (RO) and Socian <small>([[Brazil|BR]])</small>.<ref>{{cite web | title=Amisulpride international | website=Drugs.com | date=3 February 2020 | url=https://www.drugs.com/international/amisulpride.html | access-date=26 February 2020}}</ref><ref name="EMA amisulpride">{{cite web | url=https://www.ema.europa.eu/docs/en_GB/document_library/Periodic_safety_update_single_assessment/2017/10/WC500236063.pdf | date=28 September 2017 | id=EMA/658194/2017; Procedure no.: PSUSA/00000167/201701 | title=Active substance: amisulpride | access-date=26 February 2020}}</ref>', 334 => '', 335 => '===Availability===', 336 => 'Amisulpride was not approved by the [[Food and Drug Administration]] for use in the United States until February 2020, but it is used in Europe,<ref name="EMA amisulpride" /> Israel, Mexico, India, New Zealand and Australia<ref name = SOLIAN/> to treat [[psychosis]] and [[schizophrenia]].<ref>{{ cite journal | author = Lecrubier, Y. | title = Consensus on the Practical Use of Amisulpride, an Atypical Antipsychotic, in the Treatment of Schizophrenia | journal = Neuropsychobiology | volume = 44 | pages = 41–46 | year = 2001 | doi = 10.1159/000054913 | pmid = 11408792 | issue = 1 |display-authors=etal}}</ref><ref>{{ cite journal | author = Kaplan, A. | title = Psychotropic Medications Around the World | journal = Psychiatric Times | volume = 21 | issue = 5 | year = 2004 | url = http://www.psychiatrictimes.com/showArticle.jhtml?articleID=175802519 }}</ref>', 337 => '', 338 => 'Amisulpride was approved for use in the United States in February 2020.<ref>{{cite web | title=Barhemsys: FDA-Approved Drugs | website=U.S. [[Food and Drug Administration]] (FDA) | url=https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=209510 | access-date=26 February 2020}}</ref><ref name="Barhemsys label" />', 339 => '', 340 => '{{-}}', 341 => '', 342 => '==References==', 343 => '{{Reflist}}', 344 => '', 345 => '==External links==', 346 => '* {{cite web| url = https://druginfo.nlm.nih.gov/drugportal/name/amisulpride | publisher = U.S. National Library of Medicine| work = Drug Information Portal | title = Amisulpride }}', 347 => '* {{ClinicalTrialsGov|NCT01991860}}', 348 => '* {{ClinicalTrialsGov|NCT02337062}}', 349 => '', 350 => '{{Antipsychotics}}', 351 => '{{Antidepressants}}', 352 => '{{Navboxes', 353 => '| title = [[Pharmacodynamics]]', 354 => '| titlestyle = background:#ccccff', 355 => '| list1 = ', 356 => '{{Dopamine receptor modulators}}', 357 => '{{GHB receptor modulators}}', 358 => '{{Serotonin receptor modulators}}', 359 => '}}', 360 => '{{Portal bar | Pharmacy and pharmacology | Medicine}}', 361 => '', 362 => '[[Category:5-HT2B antagonists]]', 363 => '[[Category:5-HT7 antagonists]]', 364 => '[[Category:Anilines]]', 365 => '[[Category:Antidepressants]]', 366 => '[[Category:Antiemetics]]', 367 => '[[Category:Atypical antipsychotics]]', 368 => '[[Category:Benzosulfones]]', 369 => '[[Category:D2 antagonists]]', 370 => '[[Category:D3 antagonists]]', 371 => '[[Category:GHB receptor ligands]]', 372 => '[[Category:Pyrrolidines]]', 373 => '[[Category:Salicylamide ethers]]' ]