Edit filter log

[ 0 => '{{User:HBC Archive Indexerbot/OptIn', 1 => '|target=/Archive index', 2 => '|mask=/Archive <#>', 3 => '|leading_zeros=0', 4 => '|indexhere=yes}}', 5 => '{{User:MiszaBot/config', 6 => '|maxarchivesize = 250K', 7 => '|counter = 2', 8 => '|minthreadsleft = 1', 9 => '|algo = old(180d)', 10 => '|archive = Talk:Asthma/Archive %(counter)d', 11 => '}}', 12 => '{{talkheader|search=yes}}', 13 => '{{ArticleHistory', 14 => '|action1=PR', 15 => '|action1date=20:25, 11 August 2005', 16 => '|action1link=Wikipedia:Peer review/Asthma/archive1', 17 => '|action1result=reviewed', 18 => '|action1oldid=20799647', 19 => '|action2=FAC', 20 => '|action2date=11:27, 2 September 2005', 21 => '|action2link=Wikipedia:Featured article candidates/Asthma/archive1', 22 => '|action2result=promoted', 23 => '|action2oldid=22382627', 24 => false, 25 => '|action3=PR', 26 => '|action3date=20:16, 9 July 2008', 27 => '|action3link=Wikipedia:Peer review/Asthma/archive2', 28 => '|action3result=reviewed', 29 => '|action3oldid=224643331', 30 => false, 31 => '|action4=FAR', 32 => '|action4date=22:49, 14 December 2008', 33 => '|action4link=Wikipedia:Featured article review/Asthma/archive1', 34 => '|action4result=removed', 35 => '|action4oldid=257752442', 36 => false, 37 => '|action5=PR', 38 => '|action5date=17:51, 9 November 2010', 39 => '|action5link=Wikipedia:Peer review/Asthma/archive3', 40 => '|action5result=reviewed', 41 => '|action5oldid=395732211', 42 => false, 43 => '|action6=GAN', 44 => '|action6date=22:53, 27 January 2013', 45 => '|action6link=Talk:Asthma/GA1', 46 => '|action6result=listed', 47 => '|action6oldid=535170724', 48 => false, 49 => '|maindate=October 5, 2005', 50 => '|currentstatus=FFA/GA', 51 => '|topic=Biology and medicine', 52 => '}}', 53 => '{{WPMED|class=GA|importance=Top|pulmonology=yes|pulmonology-imp=Top|MCOTM=prev|selected=yes|translation=yes |translation-imp=Top }}', 54 => '{{WP1.0|v0.5=pass|class=GA|importance=mid|category=Natsci}}', 55 => '{{Backwardscopy|title=ASTHMA, the alternative approach|url= http://books.google.ca/books?id=1OOnpq_CCWAC&pg=PT24 |author= Erika Szabo| year=2012|comments=Extensive copy and pastes of large sections of Wikipedia without appropriate attribution or release under the appropriate license.}} ', 56 => '{{Maintained|[[User talk:Jmh649|James Heilman, MD]]}}', 57 => false, 58 => '== Big Tobacco still up to its "health effects are controversial" tricks ==', 59 => false, 60 => 'Some of the comments above are difficult to understand other than as an attempt to extend tobacco sellers' decades-old "tobacco might be healthy" controversy-tricks to Wikipedia's asthma page, and to minimize or obfusticate the causative role of tobacco smoke as a cause of asthma. ', 61 => false, 62 => 'Big Tobacco's attempt to create the appearance of health "controversy" wherever it can seems to me to have extended to editing Wikipedia's "[[Tobacco]]" and "[[Smoking]]" pages, and to deleting mention of Big Tobacco's circumvention of its advertising agreements by product placement in movies from the [[Product Placement]] article. ', 63 => false, 64 => 'Just as product placement in media such as movies is devastatingly effective advertising because it appears not to be advertising, misinformation planted in Wikipedia is devastatingly effective because those expecting to rely on it expect straight information, and do not expect it to be skewed for the profits of the tobacco sellers. ', 65 => false, 66 => 'To the extent that the tobacco sellers succeed in extending the appearance of "controversy" to Wikipedia and depriving a new generation of the information needed to make a fully-informed decision about becoming a tobacco buyer, the tobacco sellers' direct and indirect profits will be huge and worldwide. It's censoring and throwing half-baked, off-topic studies to generate the appearance of "controversy" amount to subtle vandalism, and to the extent these tricky context tamperings are effective, are designed to suggest to impressionable preteens considering smoking -- tobacco seller's favorite marketing group -- that the health effects of tobacco use are, after all, in doubt. ', 67 => false, 68 => 'Tampering with Wikipedia to dilute the fact that tobacco costs are far higher than the price per pack should be viewed as a call to Wikipedians familiar with the science on the issue to ensure that ', 69 => false, 70 => '(1) the science and facts needed to evaluate tobacco's risks and costs in context, and the insidious marketing strategies of tobacco sellers, are not allowed to be quietly deleted from the relevant pages, ', 71 => false, 72 => '(2) that tobacco sellers' smoke screen of off-topic implications that tobacco use might be healthy is addressed by full factual context, and ', 73 => false, 74 => '(3) that health professionals realize that there is a continuing need for vigilance in guarding the pages where potentially profitable young customers for Big Tobacco will come looking for presumably-accurate information -- that making sure that information is reliable -- not jimmied to increase sales -- is an ongoing public health issue. <small><span class="autosigned">—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:68.165.11.209|68.165.11.209]] ([[User talk:68.165.11.209|talk]] • [[Special:Contributions/68.165.11.209|contribs]]) 17:49, 22 March 2008</span></small><!-- Template:Unsigned -->', 75 => false, 76 => '== Refs ==', 77 => false, 78 => '*{{cite journal |author=Moore WC, Pascual RM |title=Update in asthma 2009 |journal=American Journal of Respiratory and Critical Care Medicine |volume=181 |issue=11 |pages=1181–7 |year=2010 |month=June|pmid=20516492 |doi=10.1164/rccm.201003-0321UP}}', 79 => '*GINA Guidelines updated to 2011 http://www.ginasthma.org/uploads/users/files/GINA_Report2011_May4.pdf', 80 => '[[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 12:56, 26 November 2012 (UTC)', 81 => false, 82 => '{{Talk:Asthma/GA1}}', 83 => false, 84 => '== Comments ==', 85 => false, 86 => 'James asked me to read the article and offer comments.', 87 => '* Intro: it would be helpful to inform the reader in a few words what atopic syndrome is (because a distinction is introduced). I would add systemic steroids and possibly phosphodiesterase inhibitors to the acute treatments, perhaps with the caveat that they are used in more severe acute asthma.', 88 => '::Added definition of atopy. The use of theophylline is controversial (which I have added). I do not think it is of great enough significance for the lead. Will add iv steroids and magnesium which has better evidence.[[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 11:47, 20 January 2013 (UTC)', 89 => '* Signs and symptoms: it might be better to expand this section a little. Normal asthma-related sputum is clear or yellow (and bursting with eosinophils), but the presence of green sputum is taken (in the BTS/SIGN guidelines) as evidence of bacterial bronchitis as a trigger. Perhaps the statement on comorbid psychological disorders could be expanded, in the sense that we don't know whether this is "chicken or egg" and which disorders in particular stand out.', 90 => '::There is evidence that sputum color says little about infection type.[http://en.wikipedia.org/wiki/Common_misconceptions_about_the_brain#Human_body_and_health][http://books.google.ca/books?id=ZzlX2zJMbdgC&pg=PA62] I am unable to find "green sputum" in the SIGN guideline. While add that it is typically mucous like. Added further details about psychological problems. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 12:08, 20 January 2013 (UTC)', 91 => '* Causes: the word "epigenetic" may benefit from a short explanation. In the "genetic" section, I believe the gene names may need to be italicised. I would rephrase the statement about Churg-Strauss, because to the best of my knowledge asthma is not associated with other forms of vasculitis.', 92 => '::Done [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 12:53, 20 January 2013 (UTC)', 93 => '* Pathophysiology: this section is awfully brief, and there is quite a lot more to be said about interactions between cell types and the various cytokines. It can be hard to present this stuff in a readable fashion for the layperson.', 94 => '::Agree, hate writing this section and would love some help :-) [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 12:53, 20 January 2013 (UTC)', 95 => '* Diagnosis: in the "classification" section the GINA definition should perhaps be moved to the introduction. In "exercise-induced asthma" it is unclear whether the 3% of bobsled racers have exercised-induced asthma or bronchoconstriction.', 96 => '::Agree and fixed the first one. They have changed the name of "exercise induced asthma" to "exercise induced brochoconstruction". [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 13:00, 20 January 2013 (UTC)', 97 => '* Prevention: no comments', 98 => '* Management: the opening paragraphs do not seem to distinguish between mild symptoms controlled with bronchodilators or acute exacerbations. While one can certainly be the heralding of the other, most sources treat these phenomena as distinct. I recall that LTAs are more useful in those with exercise-induced symptoms - is this reflected in the sources? I would be very cautious with bronchial thermoplasty - from what I've heard the initial response is worsening of asthma symptoms, and limited long-term data is available.', 99 => '::Have toned down the thermoplasty comments. And added more details regarding LTAs. They are still not first line in exercise induced symptoms and have not seen any sold evidence which supports a special use in this group.[[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 13:14, 20 January 2013 (UTC)', 100 => '* Prognosis: no comments', 101 => '* Epidemiology: the text contradicts the image, with African countries having a higher rate of asthma than many other countries. Is there an explanation why South Africa is so severely affected?', 102 => '::For most of Africa there is simply no data on frequency rates. South Africa of course is a semi first world country and thus one would expect rates similar to other semi first world countries. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 13:30, 20 January 2013 (UTC)', 103 => '* History: no comments, except for the fact that it leaves off in the 1950s and could still include some more modern developments', 104 => '::Hate writing history sections too :-) [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 13:30, 20 January 2013 (UTC)', 105 => 'Hope this helps. [[User:Jfdwolff|JFW]]&nbsp;&#124;&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 00:30, 2 January 2013 (UTC)', 106 => false, 107 => '== More comments ==', 108 => false, 109 => 'From the lead section, paragraph 2: "''Asthma may also be classified as atopic (extrinsic) or non-atopic (intrinsic) where atopy refers to a predisposition toward developing certain hypersensitivity reactions.''" Shouldn't this be type 1 hypersensitivity? I do not believe that the American Heritage Dictionary of the English Language is a suitable source for the definition of "atopy". [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 13:12, 20 January 2013 (UTC)', 110 => '::It appears that Dorlands has locked itself down and no longer gives e access. Do we have a better source to clarify this? [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] ·[[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 13:16, 20 January 2013 (UTC)', 111 => '::: I shall look for some sources later. Leave it with me. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 13:25, 20 January 2013 (UTC)', 112 => ':::: From Black's Medical Dictionary, 41st edition (2005):-', 113 => false, 114 => ':::: Atopy, meaning out of place, is a form of hyper-sensitivity characterised&mdash;amongst other features&mdash;by a familial tendency. It is due to the propensity of the affected individual to produce large amounts of reagin antibodies which stick to mast cells in the mucosa, so that when the antigen is inhaled, histamine is released from the mast cell. Atopy is the condition responsible for asthma and hay fever (see also allergy). It is estimated that 10 per cent of the human race is subject to atopy. (See also dermatitis.)', 115 => false, 116 => ':::: From Stedman's Medical Dictionary (2000):-', 117 => false, 118 => ':::: Atopy: A genetically determined state of hypersensitivity to environmental allergens. Type I allergic reaction is associated with the IgE antibody and a group of diseases, principally asthma, hay fever, and atopic dermatitis.', 119 => false, 120 => ':::: "ABC of Asthma" and "ABC of Allergy" both include IgE in their definitions of atopy. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 22:22, 21 January 2013 (UTC)', 121 => '::::: I have adjusted the text and changed the reference. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 23:08, 23 January 2013 (UTC)', 122 => false, 123 => 'In the lead section, paragraph 3, why no mention of LABAs? [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 13:15, 20 January 2013 (UTC)', 124 => '::They are second line and controversial. Thus left the discussion for the body of the text. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 13:17, 20 January 2013 (UTC)', 125 => '::: "Controversial"? I have to disabuse you of that concept. Of course they should be used only in conjunction with an inhaled corticosteroid. However I am sure that you are aware of the benefits of this synergistic use, and the widespread use of Seretide (Advair) and Symbicort. In the "Medications" subsection, the current text is rather alarmist in its presentation of LABAs. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 13:23, 20 January 2013 (UTC)', 126 => '::::Looking at the evidence and we have this 2012 Cochrane review which found increased adverse effects even when used in combination with steroids. [http://www.ncbi.nlm.nih.gov/pubmed/22513944]', 127 => '::::These meds are very strongly promoted with many drug reps doing the rounds. They have even come and visited me in the ER. Of course they are widely used as advertising works (remember [[Vioxx]]). Yes I may be a little cynical but... [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 13:38, 20 January 2013 (UTC)', 128 => ':::::Okay added a bunch of stuff. The picture seen is still not very rosy but I do not think this is my fault. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 13:54, 20 January 2013 (UTC)', 129 => ':::::: Fair enough, there does seem to be a small increase in the risk of serious adverse events with formoterol: Cochrane quotes a number needed to harm of 149. In comparison to the increased control that most patients receive, especially when used in a combination device? The benefits far outweigh this small risk. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 20:26, 20 January 2013 (UTC)', 130 => ':::::::Do we have a ref that states that the benefits far outweight the risks? We have this ref [http://www.ncbi.nlm.nih.gov/pubmed/23076961] quantifies the risk at 3/1000 per 3 months. And than we have this study [http://www.ncbi.nlm.nih.gov/pubmed/22926172] which states that increased ICS is the same as adding LABA. While they do increase PEF [http://www.ncbi.nlm.nih.gov/pubmed/19588447] how meaningful of an end point is this? [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 06:58, 21 January 2013 (UTC)', 131 => ':::::::::And than the risk of industry involvement. [http://www.ncbi.nlm.nih.gov/pubmed/21390219] [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 07:02, 21 January 2013 (UTC)', 132 => false, 133 => ':::::::::: Those studies are looking at children, which admittedly isn't my area of expertise. [http://www.brit-thoracic.org.uk/Portals/0/Guidelines/AsthmaGuidelines/sign101%20Jan%202012.pdf The BTS guideline] states (on page 41): "''Children'': Administration of inhaled steroids at or above 400 micrograms BDP a day or equivalent may be associated with systemic side effects. These may include growth failure and adrenal suppression." 400 micrograms is a moderate dose for children. I believe that mild-moderate growth failure can't really be pinpointed in individual patients, but only in treated cohorts. Thus I do not think that it would be reported as a serious adverse event.', 134 => false, 135 => ':::::::::: On page 42 of the guideline: "No exact dose of inhaled steroid can be deemed the correct dose at which to add another therapy. The addition of other treatment options to inhaled steroids has been investigated at doses from 200-1,000 micrograms BDP in adults and up to 400 micrograms BDP in children. Many patients will benefit more from add-on therapy than from increasing inhaled steroids above doses as low as 200 micrograms BDP/day. At doses of inhaled steroid above 800 micrograms BDP/day side effects become more frequent. An absolute threshold for introduction of add-on therapy in all patients cannot be defined."', 136 => false, 137 => ':::::::::: Page 43 continues: "The first choice as add-on therapy to inhaled steroids in adults and children (5-12 years) is an inhaled long-acting β2 agonist, which should be considered before going above a dose of 400 micrograms BDP or equivalent per day and certainly before going above 800 micrograms BDP."', 138 => false, 139 => ':::::::::: Later on page 43: "''Safety of long-acting β2 agonists'': Following a review in 2007 of LABA in the treatment of adults, adolescents, and children with asthma, the Medicines and Healthcare products Regulatory Agency (MHRA) further reviewed the use of LABA, specifically in children younger than age 12 years and concluded that the benefits of these medicines used in conjunction with inhaled corticosteroids in the control of asthma symptoms outweigh any apparent risks."', 140 => false, 141 => ':::::::::: The clinical bottom line: give the inhalers that will get the patient's asthma under control, because poorly-treated asthma is worse than any potential side-effects. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 12:56, 21 January 2013 (UTC)', 142 => false, 143 => '::::::::::: I just had a look at the 2007 NHLBI guideline (which we don't use in the UK). They recommend that increasing the dose of moderate-dose glucocorticoid should be given equal weight with addition of LABA. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 13:32, 21 January 2013 (UTC)', 144 => '::::::::::::I guess I could add that "The [[British Thoracic Society]] in 2007 deemed the benefits to outweigh the risks." But it is a little old. What do you suggest? [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 14:06, 21 January 2013 (UTC)', 145 => '::::::::::::: The BTS guideline is from May 2008, revised in January 2012. The BTS guideline from "2007" is "a little old" while the NHLBI guideline from 2007 is fine? [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 14:39, 21 January 2013 (UTC)', 146 => ':::::::::::::::If they are not contradicted by more recent sources I would not have concerns. What do you think we should say? [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 15:17, 21 January 2013 (UTC)', 147 => ':::::::::::::::: I don't think that side-effects or safety concerns should be mentioned in the lead section at all. This is a general article about asthma, not a journal article about LABAs. Similarly in the "Medications" subsection, we should remember that this is a general article about asthma, not guidance for doctors on the management of asthma. Extended discussion about side-effects should be avoided. My recommendation:-', 148 => false, 149 => ':::::::::::::::: "Long-acting beta-adrenoceptor agonists (LABA) such as salmeterol and formoterol can improve symptoms when given in combination with inhaled glucocorticoids. This often achieves better asthma control, although there is a slightly increased risk of serious adverse events."', 150 => false, 151 => ':::::::::::::::: [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 15:58, 21 January 2013 (UTC)', 152 => '{{od}}Okay have adjusted to more or less match this excepted added in a bit about the effect being less certain in children. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 01:58, 22 January 2013 (UTC)', 153 => ': I have changed "symptoms" to "side-effects" to avoid confusion with asthma symptoms. I am still not entirely happy, but I think that we have a reasonable compromise. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 22:06, 23 January 2013 (UTC)', 154 => '::Okay thanks. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 22:07, 23 January 2013 (UTC)', 155 => '===LTA===', 156 => 'There seems to be some bias against leukotriene antagonists, both in the lead section (paragraph 3) and in the "Medications" subsection. The text seems to imply that LTAs are used instead of inhaled steroids, yet this is very rarely the case. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 13:19, 20 January 2013 (UTC)', 157 => '::Have not seen much evidence supporting their us. Will look again. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 13:38, 20 January 2013 (UTC)', 158 => ':::GINA only mentions them twice and as second line agents [http://www.ginasthma.org/uploads/users/files/GINA_Report2011_May4.pdf] [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 13:59, 20 January 2013 (UTC)', 159 => '::::Agree with your concerns regarding the lead and adjusted it. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 14:07, 20 January 2013 (UTC)', 160 => '::::: I am still unhappy with the "Medications" subsection, which describes LTAs as "''an alternative to inhaled glucocorticoids''", despite the caveat "''not preferred''". Also, I don't think that "''less preferentially''" needs to be mentioned in the lead either. By the way, in the under 5 age group, the BTS guideline recommends LTAs as second line treatment ahead of LABAs. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 13:15, 21 January 2013 (UTC)', 161 => '::::::How do you think they should be described? [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 13:21, 21 January 2013 (UTC)', 162 => '::::::: I think that the issue is surrounding the NHLBI guideline. Does anyone actually use LTAs instead of inhaled glucocorticoids? In the UK, no-one does. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 13:35, 21 January 2013 (UTC)', 163 => '::::::::GINA on pg 32 states they can be used as a non recommended alternative in adults. [http://www.ginasthma.org/uploads/users/files/GINA_Report2011_May4.pdf] I have never come across a reason to use them alone :-) [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 14:00, 21 January 2013 (UTC)', 164 => '::::::::: How about we say that LTAs are recommended as second/third line treatment? [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 14:45, 21 January 2013 (UTC)', 165 => '::::::::::Would be fine with that and changed. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 15:17, 21 January 2013 (UTC)', 166 => '::::::::::: Thanks. In the lead section, I don't think that there is any need to include the qualifier "less preferentially". [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 16:05, 21 January 2013 (UTC)', 167 => '{{od}}Yes as LABA are not recommended LT become the second line agent. Removed the preferential bit and added these details to the treatment section. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 02:09, 22 January 2013 (UTC)', 168 => ': I have altered the text about LTAs. I have included montelukast; montelukast was the first available LTA. Also, its once daily dosing makes it preferable to zafirlukast, at least in the UK. I am now happy with the description of LTAs. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 15:10, 22 January 2013 (UTC)', 169 => '::Looks good. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 17:36, 22 January 2013 (UTC)', 170 => '::: Okay, thanks. [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 22:22, 23 January 2013 (UTC)', 171 => false, 172 => '== Steroids, corticosteroids, glucocorticoids ==', 173 => false, 174 => 'In the lead section and the rest of the article, this class is variously named. While technically correct, perhaps use a single term for consistency and clarity? [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 14:59, 22 January 2013 (UTC)', 175 => ':Okay went with steroids. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 17:36, 22 January 2013 (UTC)', 176 => ':: The "Management" section still includes many references to "glucocorticoids". (For what it's worth, I think that "glucocorticoids" is preferable because it is more precise, and less likely to be confused with anabolic steroids, but I don't have a strong opinion on this.) [[User:Axl|<font color="#808000">'''Axl'''</font>]] <font color="#3CB371">¤</font> <small>[[User talk:Axl|<font color="#808000">[Talk]</font>]]</small> 18:16, 22 January 2013 (UTC)', 177 => ':::Yes Wikipedia is just coming up again. Will work on it. Okay think I have it now. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine)', 178 => false, 179 => '== Reader feedback ==', 180 => false, 181 => 'I just had a quick look at the reader feedback for this page, a lot of it seems focused on wanting more diagrams and less complex terminology. I don't know whether it might be worth adding a hatnote to the article suggesting that if the medical terminology is too complex, and you just want to get a quick understanding of the causes, symptoms and treatments then you might want to look at the 'simple english' wikipedia entry [[:simple:asthma]]? I guess that article ought to be looked at carefully too. In fact I wonder whether that ought to be a template of some sort that applied to all medical articles? [[User:EdwardLane|EdwardLane]] ([[User talk:EdwardLane|talk]]) 10:29, 11 February 2013 (UTC)', 182 => '::There is discussion to move simple English to the top of the language list for those looking for simple content. I think that is a good and reasonable compromise. THe feedback recommends more pictures. More pictures of what? [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 20:01, 11 February 2013 (UTC)', 183 => ':::The discussion you mention looks interesting, I'm not opposed to that, and I think I'll probably respond to the thread on wp medicine when I get a moment. It is not exactly clear what the 'simplify the language' feedback wants in terms of diagrams - The article here might perhaps like a diagrams showing general lung function and perhaps a comparison between normal function and an asthmatic episode? [[User:EdwardLane|EdwardLane]] ([[User talk:EdwardLane|talk]]) 11:55, 12 February 2013 (UTC)', 184 => '::::You mean a picture of the out put of a PFT for asthma versus COPD versus normal. We could do that. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 12:05, 12 February 2013 (UTC)', 185 => ':::::not exactly but looking at the [[spirometry]] page there might be something in that idea. I'll describe my suggestion again when I have abit more time [[User:EdwardLane|EdwardLane]] ([[User talk:EdwardLane|talk]]) 16:54, 12 February 2013 (UTC)', 186 => false, 187 => '== Edit request on 6 March 2013 ==', 188 => false, 189 => '{{edit semi-protected|answered=yes}}', 190 => '<!-- Begin request -->', 191 => '* [[Methylxanthines]] (such as [[theophylline]]) were once widely used, but do not add significantly to the effects of inhaled beta-agonists.<ref name=rodrigo/> There use in acute exacerbations is controversial.<ref name=GINA_2011_page37>{{harvnb|GINA|2011|p=37}}</ref>', 192 => 'should be changed to', 193 => '* [[Methylxanthines]] (such as [[theophylline]]) were once widely used, but do not add significantly to the effects of inhaled beta-agonists.<ref name=rodrigo/> Their use in acute exacerbations is controversial.<ref name=GINA_2011_page37>{{harvnb|GINA|2011|p=37}}</ref>', 194 => '<!-- End request -->', 195 => '[[User:Alanlcit|Alanlcit]] ([[User talk:Alanlcit|talk]]) 05:01, 6 March 2013 (UTC)', 196 => ':{{ESp|d}} [[User:BryanG|BryanG]] ([[User talk:BryanG|talk]]) 05:38, 6 March 2013 (UTC)', 197 => false, 198 => '== Hygeine Hypothesis ==', 199 => false, 200 => '"The hygiene hypothesis is a theory which attempts to explain the increased rates of asthma worldwide as a direct and unintended result of reduced exposure, during childhood, to non–infectious bacteria and viruses.[42][43]"', 201 => false, 202 => 'Should this not be 'non-pathogenic bacteria and viruses'? Aren't all bacteria and viruses infectious?', 203 => false, 204 => '[[User:Tomwebber92|Tomwebber92]] ([[User talk:Tomwebber92|talk]]) 09:28, 10 April 2013 (UTC)', 205 => '::Thanks excellent point. [[User:Jmh649|<span style="color:#0000f1">'''Doc James'''</span>]] ([[User talk:Jmh649|talk]] · [[Special:Contributions/Jmh649|contribs]] · [[Special:EmailUser/Jmh649|email]]) (if I write on your page reply on mine) 01:20, 11 April 2013 (UTC)' ]