Mir-103/107 microRNA precursor: Difference between revisions
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The '''miR-103 microRNA precursor''' ([[homology (biology)|homologous]] to miR-107), is a short [[non-coding RNA]] gene involved in [[gene regulation]]. |
The '''miR-103 microRNA precursor''' ([[homology (biology)|homologous]] to miR-107), is a short [[non-coding RNA]] gene involved in [[gene regulation]]. |
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miR-103 and miR-107 have now been predicted or experimentally confirmed in [[Homo sapiens|human]].<ref name="pmid11914277">{{cite journal |author=Mourelatos Z |title=miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs |journal=Genes Dev. |volume=16 |issue=6 |pages=720–8 |year=2002 |pmid=11914277 |doi=10.1101/gad.974702 |pmc=155365 |name-list-format=vanc|author2=Dostie J |author3=Paushkin S |display-authors=3 |last4=Sharma |first4=A |last5=Charroux |first5=B |last6=Abel |first6=L |last7=Rappsilber |first7=J |last8=Mann |first8=M |last9=Dreyfuss |first9=G}}</ref><ref>{{cite web|title=miRNA gene family: mir-103|url=http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000024|work=mirBASE|publisher=University of Manchester|accessdate=5 September 2011}}</ref> |
miR-103 and miR-107 have now been predicted or experimentally confirmed in [[Homo sapiens|human]].<ref name="pmid11914277">{{cite journal |author=Mourelatos Z |title=miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs |journal=Genes Dev. |volume=16 |issue=6 |pages=720–8 |year=2002 |pmid=11914277 |doi=10.1101/gad.974702 |pmc=155365 |name-list-format=vanc|author2=Dostie J |author3=Paushkin S |display-authors=3 |last4=Sharma |first4=A |last5=Charroux |first5=B |last6=Abel |first6=L |last7=Rappsilber |first7=J |last8=Mann |first8=M |last9=Dreyfuss |first9=G}}</ref><ref>{{cite web|title=miRNA gene family: mir-103|url=http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000024|work=mirBASE|publisher=University of Manchester|accessdate=5 September 2011|deadurl=yes|archiveurl=https://archive.is/20120710015407/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000024|archivedate=10 July 2012|df=}}</ref> |
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[[microRNA]]s are transcribed as ~70 [[nucleotide]] precursors and subsequently processed by the [[Dicer]] enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from |
[[microRNA]]s are transcribed as ~70 [[nucleotide]] precursors and subsequently processed by the [[Dicer]] enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from |
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==External links== |
==External links== |
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* {{Rfam|id=RF00129|name=mir-103/107 microRNA precursor}} |
* {{Rfam|id=RF00129|name=mir-103/107 microRNA precursor}} |
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* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000024 miRBase family MIPF0000024] |
* [https://archive.is/20120710015407/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000024 miRBase family MIPF0000024] |
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{{miRNA precursor families}} |
{{miRNA precursor families}} |
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Revision as of 18:23, 1 February 2018
| mir-103/107 microRNA precursor | |
|---|---|
 Predicted secondary structure and sequence conservation of mir-103 | |
| Identifiers | |
| Symbol | mir-103 |
| Rfam | RF00129 |
| miRBase | MI0000109 |
| miRBase family | MIPF0000024 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | GO:0035195 GO:0035068 |
| SO | SO:0001244 |
| PDB structures | PDBe |
The miR-103 microRNA precursor (homologous to miR-107), is a short non-coding RNA gene involved in gene regulation. miR-103 and miR-107 have now been predicted or experimentally confirmed in human.[1][2]
microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.[3]
mir-103 and mir-107 were noted as being upregulated in obese mice and were subsequently found to have a key role in insulin sensitivity. This led to a suggestion that these microRNAs represent potential targets for the treatment of type 2 diabetes.[4]
mir-103 has also been linked with chronic pain[5] and intestinal cell proliferation.[6]
Recently, miR-103-3p was shown to target the 5' untranslated region (5' UTR) of GPRC5A's mRNA in pancreatic cancer.[7] This is one of only a handful of known instances where a miRNA targets the 5' UTR of a mRNA.
References
- ^ Mourelatos Z; Dostie J; Paushkin S; et al. (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.
{{cite journal}}: Unknown parameter|name-list-format=ignored (|name-list-style=suggested) (help) - ^ "miRNA gene family: mir-103". mirBASE. University of Manchester. Archived from the original on 10 July 2012. Retrieved 5 September 2011.
{{cite web}}: Unknown parameter|deadurl=ignored (|url-status=suggested) (help) - ^ Ambros V (2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ^ Trajkovski, M; Hausser, J; Soutschek, J; Bhat, B; Akin, A; Zavolan, M; Heim, MH; Stoffel, M (Jun 8, 2011). "MicroRNAs 103 and 107 regulate insulin sensitivity". Nature. 474 (7353): 649–53. doi:10.1038/nature10112. PMID 21654750.
- ^ Favereaux, A; Thoumine, O; Bouali-Benazzouz, R; Roques, V; Papon, MA; Salam, SA; Drutel, G; Léger, C; Calas, A; Nagy, F; Landry, M (Jul 29, 2011). "Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain". The EMBO Journal. 30 (18): 3830–41. doi:10.1038/emboj.2011.249. PMC 3173784. PMID 21804529.
- ^ Liao, Y; Lönnerdal, B (Sep 23, 2010). Langsley, Gordon (ed.). "Global MicroRNA Characterization Reveals That miR-103 Is Involved in IGF-1 Stimulated Mouse Intestinal Cell Proliferation". PLoS ONE. 5 (9): e12976. doi:10.1371/journal.pone.0012976. PMC 2944884. PMID 20886090.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Zhou, H; Rigoutsos, I (Jul 1, 2014). "MiR-103a-3p targets the 5′ UTR of GPRC5A in pancreatic cells". RNA. 20: 1431–9. doi:10.1261/rna.045757.114. PMC 4138326. PMID 24984703.
External links