Talk:Dendrodendritic synapse

Notes for class editors: When we started this project, there was no existing page for this topic. There were not many secondary sources on this topic, especially ones that focused exclusively on dendrodendritic synapses. We tried to create a solid foundational page giving a good overview of the topic. Veterinarydreams (talk) 14:11, 2 April 2015 (UTC)

Primary Reviews

Primary Review 1

1] This article was for the most part well written, especially considering the fact that the page had not been created before. The article flowed nicely and was clear and concise because it was written in a language was understandable to the general public. There were a couple of grammatical errors throughout the article:

• in the lead section, "similar synapses are activated in a similar fashion **to** axodendritic synapses"
• comma needed in sentence "while studying the mammalian olfactory bulb**,** they found..."
• in same sentence as above, the verb tenses don't match ("coupled & send" vs. "couple and send")

2] The reference list was for the most part okay, with a couple of errors.

• sources 2 & 7 don't appear to be secondary sources and source 2 doesn't follow the same information on Na+ and Ca2+ written in the article.
• sources are repeated, so the layout of the citations needs to be formatted correctly so there is only one of each source below.
• I could only find an abstract for source 8, it could be helpful if you found the full article.

3] While it is understandable that there was little research, I found the article to be somewhat vague. The lead paragraph talked about how dendrodendritic synapses have a variety of similar aspects to axodendritic synapses, but didn't expand on the commonalities the two shared. It could be helpful to expand on the topics just a little bit more so the reader doesn't have to look up and read a ton about axodendritic synapses as well. For example, when talking about how dendrodendritic synapses are activated, you could explain it briefly instead of saying it is activated in a similar way to axodendritic synapses. I also think the article could be more in depth by adding a mechanism section talking about the biology of the synapses. There were a couple of areas in the lead section that were not followed up in the body portion of the article. I thought the history and location portion were done very well. I think if possible, the neuroplasticity section could be explained more if there is information on the experiment mentioned or about the causes/effects dendrodendritic synapses have on neuroplasticity.

4] The article was written with a neutral viewpoint without bias.

5] The article is stable and should be susceptible to change from "edit wars".

6] An image could be helpful when distinguishing axodendritic and dendrodendritic synapses, but not necessary. If you are to go into further depth on the mechanisms, an image could be helpful there as well.

Overall, I think you guys did an awesome job and I found your article really interesting to read! I double checked your source #3 and it seemed in line with what you wrote. Keep up the good work! Rayschneider0 (talk) 05:39, 13 April 2015 (UTC)Rayschneider0Rayschneider0 (talk) 05:39, 13 April 2015 (UTC)

Response: Thanks for the thorough review. I will be making those grammar changes and fixing the citations errors asap. As for article 8 I am not sure why you could only find an abstract since we found the whole article. It may be that it is only accessible through marquette's network since they pay to have access to these articles. I am sorry to have to say I do not have a method to make them more accessible to people but I also do not think that is a job for the writer of the page to worry about. I will add a bit more information about the axodendritic synapses and dendrodendritic mechanisms of activations. It is difficult to add more to the neuroplasticity section since there is not sufficient research outside of conjectures made from what is likely to happen. An image will be added.

Primary Review 2

1) This article was written clearly and the data is presented concisely. The material was presented in a very clear language allowing for the reader to understand the topic despite the need of a scientific background that might otherwise have been necessary. Although there were a few grammar errors early on in the article, nothing too major a quick read over will help clean them up. 2) The sources were well used and are cited properly throughout the article itself however upon looking over a few of the sources it did not seem that source 2 was a secondary resource and may have been adding a little bit of bias to the article itself. The information gathered in the second article however was still very useful so if you could possible find another source that has reference to this it would be very helpful for the page. 3)The article was broad in its coverage addressing many of the main aspects of the topic itself.it was able to discuss the history, location, as well as some of the more important functions it provides for the human body. I do think it could have been useful to have gone into a little bit more of detail on the actual mechanisms involved in these specific synapses and I think it would be really interesting if the neuroplasticity was elaborated on, I work with neuron degeneration and find the topic extremely interesting and feel it could have been talked about a little bit more. 4) Besides having a primary article as a reference the page was written without bias. 5) The article seemed to be stable and would not undergo an edit war or content dispute. 6) Although there were images I feel it wouldn’t hurt to have more especially in sections based on their locations.

Overall I think that this article was written really well and allowed for the reader to easily follow the information being presented as well as to learn quite a bit in the process. It is a really good start and I think you guys did a great job.

2280zanont (talk) 01:23, 14 April 2015 (UTC)

Response: Thanks for the review. I will be making grammar changes and giving it one more proofreading.The primary article will have to say in the article because there is very little to no reviews available with large amounts of information on Dendrodendritic dendrites thus we do have rely on primary sources. I will add a bit more information neuroplasticity where possible due again to limited reseach.

Primary Review 3

1] This article was well written considering this page did not exist before; however, there were some sections that seemed to be lacking and a few minor grammatical errors. In the introduction, I think you missed the word "to" in one of your sentences. In addition, commas could be used more throughout the article to break up your thoughts and sentences. There are also differing verb tenses throughout the article. For example, in the history section, you use "could" and "can" in the bulleted sentences, but it would make the most sense if you were consistent here. Other than that, I would make sure that your sentences flow with one another in thought. It seemed broken-up in some places, such as the olfactory bulb section. Your article is concise which is fantastic! Not to mention, the layout and headers are very clear.

2] The sources are cited well, however I think you could pull more from them. What you got from each article was valuable, but I think there is more you could add. I don't think sources 2 and 7 are secondary sources because they are original experiments. These articles seem to be useful though so I would double check! I also had trouble finding the full article for source 2, so make sure that these are easy to obtain. Also, some of the articles were repeated twice in the citations section. I would recommend scanning through this section to make sure each source is only listed once.

3] You all did a great job of staying on topic. The information you presented is relevant and applicable. This article does a nice job of covering the history and location. I think it would be beneficial to use one or two wikilinks in the neuroplasticity section, specifically one highlighting neuroplasticity since it is the name of the section. I believe this section could go more in depth, elaborating on what role dendrodendritic synapses play in neuroplasticity. In addition, it would be beneficial to elaborate on the mechanisms involved, specifically in the olfactory bulb section. Maybe you could even go into depth about the typical mechanism involved in a chemical synapse. This would add more depth to the overall article. Because there was little research available, I understand the article may be a little more vague than initially intended. This being said, I think you can bulk it up by adding more information on the broader topics, such as the mechanisms.

4] This article was relatively neutral, but removing the primary sources will make it less biased and more neutral.

5] This article is stable and should not be susceptible to "edit wars" of any kind.

6] If possible, an image or two could be very useful, especially when distinguishing axodendritic and dendrodendritic synapses. You could even use an image to aid the location section.

I looked more into source 5 and think you could include more from this source in your article. Overall, this is a great start! This article is concise and technically written. CateNicole (talk) 23:26, 13 April 2015 (UTC)

Response: Thanks for the thorough review. I will be making grammatical changes and fixing the citations errors asap. As for article 2 I am not sure why you could only find an abstract since we found the whole article. It may be that it is only accessible through marquette's network since they pay to have access to these articles. I am sorry to have to say I do not have a method to make them more accessible to people but I also do not think that is a job for the writer of the page to worry about. The primary article will have to say in the article because there is very little to no reviews available with large amounts of information on Dendrodendritic dendrites thus we do have rely on primary sources. I will try to add more on dendrodendritic mechanisms of activations. It is difficult to add more to the neuroplasticity section since there is not sufficient research outside of conjectures made from what is likely to happen but I hope to add at least a bit of it on there. An image will be added.

Secondary Reviews

Good overview of the topic! I saw you didn't have that many sources. It did seem a little vague at times but that might just be because of sources. I think a picture of it would be nice and if not the actual synapse maybe just a neuron. It would help people understand the anatomy of it more. - Mmich25

Secondary Review 2

The article was well written and expanded especially when there was no pre-existing page present to go off of. I liked how there the different places that this synapse could be found were included and expanded upon to get better understanding of the synapse. The history section was also helpful to show how this synapse was important and also giving a time frame as to when this was going on. I also think that there could be an image, if there is one, to distinguish the difference between the axodendritic synapse that it was compared to in the beginning. Lokazaki0326 (talk) 20:05, 12 April 2015 (UTC)

Secondary Review 3

I think you should add some more wikilinks because they will help readers understand what you are saying. I know you said there were not many secondary sources, however, most of your sources are quite old. This could be a problem because our understanding of things can change very quickly as additional research is done. I think you should try to find some newer sources to cite to ensure readers that everything you are saying is up-to-date and correct. Finally, your reference list should be edited to list each source only once. This means the citations throughout you article will have to be modified. AGBiology (talk) 03:39, 13 April 2015 (UTC)

Secondary Review 4

I think the article is informative and I was interested to read and learn about the topic. I think that there a a few sections that could be expanded on if you can find anymore research and information on the topic. For example, I think the Neuroplasticity part could be expanded on to further enhance the article. I like the section on the history. I thought that was a good touch and added to the overall understanding and goal of the article. It looks like a few of your sources my be listed more than once, so maybe double check to make sure those are all correctly formatted to match your page. Good job! (Spidey1994 (talk) 14:42, 13 April 2015 (UTC))

Secondary Review 5

I think this article is a bit short but given the lack of sources available, that is understandable. I think there are ways to make the article longer by adding information. For example, expanding on the Neuroplasticity section, elaborating on the sentence "Dendrodendritic synapses are activated in a similar fashion axodendritic synapses" from the introduction, and expanding on the technology advances that made it possible for research in this topic to take off. Overall, this article gave a good overview of the topic given the resources available! Lambchop22 (talk) 03:34, 14 April 2015 (UTC)

Secondary Review 6

Overall, with respect to the limited amount of information you could find, I thought that this article was well written. However, there are a few grammatical errors that I found (punctuation and verb tense) that could be fixed to improve the article. Clarifying question: What do you mean by ‘connections’ when you say that dendrodendritic synapses are connections between the dendrites of two different neurons? Is this a physical connection where the two dendrites are touching each other? In the lead section you also mention sodium and calcium pumps playing a role in the signaling mechanism. In order to expand your article maybe you could elaborate a little more on these pumps and how they specifically affect dendrodendritic synapses. This article was interesting and informative to read especially since synapses had been the topic of discussion for a good part of our Neurobiology course. Good job! NeuroKJ (talk) 04:22, 14 April 2015 (UTC)

Thalamus

Dendrodendritic synapses are common in the thalamus. They are the most unique synaptic arrangement within the synaptic glomeruli. They are not the result of some pathology as seems to be suggested. There are a few papers on this topic, though not many. Good sources are: The original discovery: Ralston HJ 3rd. Evidence for presynaptic dendrites and a proposal for their mechanism of action. Nature. 1971 Apr 30;230(5296):585-7. A recent paper: Crandall SR, Cox CL. Local dendrodendritic inhibition regulates fast synaptic transmission in visual thalamus. J Neurosci. 2012 Feb 15;32(7):2513-22. doi: 10.1523/JNEUROSCI.4402-11.2012.Skamnelis (talk) 15:55, 12 April 2017 (UTC)

Clarify ACTION of the DD synapse?

The article says, "These chemical synapses receive a depolarizing signal from an incoming action potential which results in an influx of calcium ions that permit release of Neurotransmitters to propagate the signal the post synaptic cell."; but dendrites don't have an action potential, they have a graded potential, right? I would think a graded potential from one dendrite would not normally present a voltage sufficient to open any voltage gated calcium pores which might be present in the pre-synaptic portion of such a synapse to another dendrite? UnderEducatedGeezer (talk) 11:23, 30 June 2018 (UTC)