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{{En desarrollo|t=20210120221626}}
{{Destruir|g4||}}
{{Ficha de proteína
{{Ficha de proteína
|nombre = subunidad gamma-2 de la proteína de unión a nucleótidos de guanina
|nombre = GNG2
|nombres =Subunidad gamma-2 de la proteína de unión a nucleótidos de guanina.
|nombres =
|imagen = Protein_GNG2_PDB_1gg2.png
|imagen = Protein_GNG2_PDB_1gg2.png
|imagen_tamaño =
|imagen_tamaño =
Línea 19: Línea 17:
|LocusSupplementaryData =
|LocusSupplementaryData =


|Largo_proteína =
|Largo_proteína = 71
|Peso_molecular =
|Peso_molecular =
|Estructura =
|Estructura =
|Tipo =
|Tipo =
|Funciones =
|Funciones =Modulador o transductor en varios sistemas de señalización.
|Dominio =
|Dominio =
|Motivo = Helix, Turn, Beta strand
|Motivo = Helix, Turn, Beta strand
Línea 76: Línea 74:
|Hs_Ensembl =
|Hs_Ensembl =
|Hs_RefseqmRNA =
|Hs_RefseqmRNA =
|Hs_RefseqProtein =
|Hs_RefseqProtein = NP_001230702
|Hs_GenLoc_db =
|Hs_GenLoc_db =
|Hs_GenLoc_chr =
|Hs_GenLoc_chr =
Línea 93: Línea 91:
<!-- Info relacionada -->
<!-- Info relacionada -->
|Artículo =
|Artículo =
|Publicación     =
|Proteina=GPCR}}
|Proteina=GPCR}}
La '''subunidad gamma-2 de la proteína de unión a nucleótidos de guanina G(I) / G(S) / G(O)''' es una [[proteína]] que en los seres humanos está codificada por el [[gen]] ''GNG2'' . <ref name="pmid10833460">{{Cita publicación|título=Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit|fecha=Jul 2000|publicación=Biochem Biophys Res Commun |volumen=272|número=2|páginas=610–5|doi=10.1006/bbrc.2000.2832|pmid=10833460}}</ref> <ref name="entrez1">{{Cita web |url=https://www.ncbi.nlm.nih.gov/sites/entrezDb=gene&Cmd=ShowDetailView&TermToSearch=54331|título=Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2}}</ref>
La '''subunidad gamma-2 de la proteína de unión a nucleótidos de guanina G(I) / G(S) / G(O)''' es una [[proteína]] que en los seres humanos está codificada por el [[gen]] ''GNG2'' .<ref name="pmid10833460">{{Cita publicación |título=Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit |fecha=Jul 2000 |publicación=Biochem Biophys Res Commun |volumen=272 |número=2 |páginas=610–5 |doi=10.1006/bbrc.2000.2832 |pmid=10833460}}</ref><ref name="entrez1">{{Cita web |url=https://www.ncbi.nlm.nih.gov/sites/entrezDb=gene&Cmd=ShowDetailView&TermToSearch=54331 |título=Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2}}</ref><ref>{{Cita web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=GNG2|título=GNG2 Gene - GeneCards {{!}} GBG2 Protein {{!}} GBG2 Antibody|fechaacceso=2021-03-08|sitioweb=www.genecards.org}}</ref><ref>{{Cita web|url=https://www.omim.org/entry/606981|título=OMIM Entry
- * 606981 - GUANINE NUCLEOTIDE-BINDING PROTEIN, GAMMA-2; GNG2|fechaacceso=2021-03-08|sitioweb=www.omim.org|idioma=en-us}}</ref>


Las [[Proteína G|proteínas G]] heterotriméricas juegan un papel vital en las respuestas celulares a señales externas. La especificidad de una interacción proteína G-receptor está mediada principalmente por la subunidad gamma. [Suministrada por OMIM]<ref name="entrez">{{Cita web|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54331|título=Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2}}<cite class="citation web cs1" data-ve-ignore="true">[https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54331 "Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2"].</cite></ref>
Las [[Proteína G heterotrimérica|proteínas G heterotriméricas]] juegan un papel vital en las respuestas celulares a [[Transducción de señal|señales]] externas. La especificidad de una interacción proteína [[Receptor celular|G-receptor]] está mediada principalmente por la subunidad gamma.<ref name="entrez">{{Cita web |url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54331 |título=Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2}}</ref>


== Mapa interactivo ==
== Función ==
Las proteínas de unión a [[Nucleótido|nucleótidos]] de [[guanina]] (proteínas G) participan como moduladores o [[Transducción secuencial|transductores]] en varios sistemas de señalización transmembrana.<ref>{{Cita web|url=https://www.ncbi.nlm.nih.gov/gene/54331|título=GNG2 G protein subunit gamma 2 [Homo sapiens (human)] - Gene - NCBI|fechaacceso=2021-03-08|sitioweb=www.ncbi.nlm.nih.gov}}</ref> Las cadenas beta y gamma son necesarias para la actividad [[GTPasa]], para la sustitución de [[Guanosín difosfato|GDP]] por [[Guanosín trifosfato|GTP]] y para la interacción proteína G-efectora.<ref>{{Cita web|url=https://www.uniprot.org/uniprot/P59768|título=GNG2 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor - Homo sapiens (Human) - GNG2 gene & protein|fechaacceso=2021-03-08|sitioweb=www.uniprot.org|idioma=en}}</ref>
{{NicotineDopaminergicActivity_WP1602|highlight=GNG2}}
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<div style="visibility:hidden"><imagemap>
Image:NicotineDopaminergic_WP1602.png|right|alt=NicotineDopaminergic_WP1602
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rect 518.0 546.0 560.0 566.0 [[Cyclin-dependent_kinase_5|go to article]]
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rect 255.0 120.0 295.0 140.0 [[Potassium|Go to article]]
rect 401.0 770.0 452.0 790.0 [[Dopamine_receptor_D2|go to article]]
rect 429.0 621.0 478.0 641.0 [[GNB1|go to article]]
rect 619.0 202.0 677.0 222.0 [[CHRNA5|go to article]]
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rect 255.0 231.0 295.0 251.0 [[Potassium|Go to article]]
rect 618.4705882352949 725.2100840336135 677.4705882352949 745.2100840336135 [[L-Tyrosine|Go to article]]
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rect 190.0 591.0 235.0 611.0 [[Adenosine_triphosphate|Go to article]]
rect 246.0 815.0 314.0 835.0 [[Dopamine|Go to article]]
rect 296.75 551.25 350.0 571.25 [[Cyclic_AMP|Go to article]]
rect 619.0 182.0 677.0 202.0 [[CHRNB2|go to article]]
rect 619.3025210084037 661.5210084033617 678.3025210084037 681.5210084033617 [[L-Dopa|Go to article]]
rect 697.7310924369746 638.3697478991595 743.7310924369746 658.3697478991595 [[Aromatic_L-amino_acid_decarboxylase|Go to article]]
rect 614.5084033613451 605.1848739495794 682.5084033613451 625.1848739495794 [[Dopamine|Go to article]]
rect 142.0 436.0 196.0 456.0 [[KCNK9|go to article]]
rect 254.5 775.0 305.5 795.0 [[Dopamine_receptor_D3|go to article]]
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rect 698.7058823529412 693.8655462184876 737.7058823529412 713.8655462184876 [[Tyrosine_hydroxylase|go to article]]
rect 85.0 383.0 125.0 403.0 [[Potassium|Go to article]]
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rect 305.0 120.0 348.0 140.0 [[Sodium|Go to article]]
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rect 352.0 167.0 406.0 187.0 [[CHRNA4|go to article]]
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default [[Nicotine#Interactive_pathway_map|Go to pathway article]]
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<div class="magnify"> </div>Nicotine Activity on Dopaminergic Neurons [http://www.wikipathways.org/index.php/Pathway:WP1602 edit]
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== Referencias ==
== Referencias ==
{{Listaref}}
{{Listaref}}

== Bibliografía ==
{{refbegin | 2}}
*{{Cita publicación |título=A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase |apellidos=Pumiglia KM |nombre=|fecha=|publicación=J. Biol. Chem. |volumen=270 |número=24 |páginas=14251–4 |fechaacceso=|doi=10.1074/jbc.270.24.14251 |pmid=7782277 |apellidos3=Haske T |apellidos4=Habib |nombre4=T |apellidos5=Jove |nombre5=R |apellidos6=Decker |nombre6=SJ |año=1995 |número-autores=3 |author2=LeVine H }}
*{{Cita publicación |url=|título=Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase |apellidos=|nombre=|fecha=|publicación=Proc. Natl. Acad. Sci. U.S.A. |volumen=91 |número=23 |páginas=11256–60 |fechaacceso=|doi=10.1073/pnas.91.23.11256 |pmc=45206 |pmid=7972043 |año=1994 }}
*{{Cita publicación |url=|título=Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families |apellidos=|nombre=|fecha=|publicación=J. Biol. Chem. |volumen=271 |número=12 |páginas=7141–6 |fechaacceso=|doi=10.1074/jbc.271.12.7141 |pmid=8636150 |año=1996 }}
*{{Cita publicación |título=Direct binding of G-protein betagamma complex to voltage-dependent calcium channels |apellidos=De Waard M |publicación=Nature |volumen=385 |número=6615 |páginas=446–50 |doi=10.1038/385446a0 |pmid=9009193 |apellidos3=Walker D |apellidos4=Scott |nombre4=Victoria E. S. |apellidos5=Gurnett |nombre5=Christina A. |apellidos6=Campbell |nombre6=Kevin P. |año=1997 |número-autores=3 |author2=Liu H}}
*{{Cita publicación |título=Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits |publicación=Biochemistry |volumen=36 |número=6 |páginas=1487–95 |doi=10.1021/bi962554d |pmid=9063897 |año=1997}}
*{{Cita publicación |título=Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors |apellidos=Qin N |publicación=Proc. Natl. Acad. Sci. U.S.A. |volumen=94 |número=16 |páginas=8866–71 |doi=10.1073/pnas.94.16.8866 |pmc=23172 |pmid=9238069 |apellidos3=Olcese R |apellidos4=Stefani |nombre4=E |apellidos5=Birnbaumer |nombre5=L |año=1997 |número-autores=3 |author2=Platano D}}
*{{Cita publicación |título=Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2) |apellidos=Ong OC |publicación=Genomics |volumen=44 |número=1 |páginas=101–9 |doi=10.1006/geno.1997.4814 |pmid=9286705 |apellidos3=Rong H |apellidos4=Lee |nombre4=Rehwa H. |apellidos5=Fung |nombre5=Bernard K.-K. |año=1997 |número-autores=3 |author2=Hu K}}
*{{Cita publicación |título=Association of the proto-oncogene product dbl with G protein betagamma subunits |publicación=FEBS Lett. |volumen=459 |número=2 |páginas=186–90 |doi=10.1016/S0014-5793(99)01244-2 |pmid=10518015 |año=1999}}
*{{Cita publicación |título=Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2 |apellidos=Carman CV |publicación=J. Biol. Chem. |volumen=275 |número=14 |páginas=10443–52 |doi=10.1074/jbc.275.14.10443 |pmid=10744734 |apellidos3=Chen C |apellidos4=Liu-Chen |nombre4=LY |apellidos5=Onorato |nombre5=JJ |apellidos6=Kennedy |nombre6=SP |apellidos7=Caron |nombre7=MG |apellidos8=Benovic |nombre8=JL |año=2000 |número-autores=3 |author2=Barak LS }}
*{{Cita publicación |título=Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq |publicación=J. Biol. Chem. |volumen=276 |número=26 |páginas=23945–53 |doi=10.1074/jbc.M101154200 |pmid=11294873 |año=2001 }}
*{{Cita publicación |título=Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs |apellidos=Yu Y |publicación=Genome Res. |volumen=11 |número=8 |páginas=1392–403 |doi=10.1101/gr.175501 |pmc=311073 |pmid=11483580 |apellidos3=Zhou G |apellidos4=Wu |nombre4=S |apellidos5=Qu |nombre5=X |apellidos6=Wei |nombre6=H |apellidos7=Xing |nombre7=G |apellidos8=Dong |nombre8=C |apellidos9=Zhai |nombre9=Y |año=2001 |número-autores=3 |author2=Zhang C}}
*{{Cita publicación |título=G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase |publicación=J. Biol. Chem. |volumen=277 |número=2 |páginas=1488–92 |doi=10.1074/jbc.M110390200 |pmid=11698416 |año=2002|autores= Lowry W.E., Huang X-Y }}
*{{Cita publicación |título=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |apellidos=Strausberg RL |publicación=Proc. Natl. Acad. Sci. U.S.A. |volumen=99 |número=26 |páginas=16899–903 |doi=10.1073/pnas.242603899 |pmc=139241 |pmid=12477932 |apellidos3=Grouse LH |apellidos4=Derge |nombre4=JG |apellidos5=Klausner |nombre5=RD |apellidos6=Collins |nombre6=FS |apellidos7=Wagner |nombre7=L |apellidos8=Shenmen |nombre8=CM |apellidos9=Schuler |nombre9=GD |año=2003 |número-autores=3 |author2=Feingold EA}}
*{{Cita publicación |título=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta |apellidos=Cuello F |publicación=J. Biol. Chem. |volumen=278 |número=9 |páginas=7220–6 |doi=10.1074/jbc.M210304200 |pmid=12486123 |apellidos3=Heemeyer F |apellidos4=Meyer |nombre4=HE |apellidos5=Lutz |nombre5=S |apellidos6=Jakobs |nombre6=KH |apellidos7=Niroomand |nombre7=F |apellidos8=Wieland |nombre8=T |año=2003 |número-autores=3 |author2=Schulze RA }}
*{{Cita publicación |url=|título=The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells|fecha=|publicación=J. Physiol. |volumen=546 |número=Pt 2 |páginas=337–47 |autores= Melliti K., Grabner M., Seabrook G.R. |doi=10.1113/jphysiol.2002.026716 |pmc=2342512 |pmid=12527722 |año=2003 }}
*{{Cita publicación |título=T-type calcium channel regulation by specific G-protein betagamma subunits |apellidos=Wolfe JT |publicación=Nature |volumen=424 |número=6945 |páginas=209–13 |doi=10.1038/nature01772 |pmid=12853961 |apellidos3=Howard J |apellidos4=Garrison |nombre4=James C. |apellidos5=Barrett |nombre5=Paula Q. |año=2003 |número-autores=3 |author2=Wang H}}
*{{Cita publicación |título=G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production |apellidos=Niu J |publicación=Circ. Res. |volumen=93 |número=9 |páginas=848–56 |doi=10.1161/01.RES.0000097607.14733.0C |pmid=14512443 |apellidos3=Pan H |apellidos4=Vaiskunaite |nombre4=R |apellidos5=Voyno-Yasenetskaya |nombre5=T |año=2003 |número-autores=3 |author2=Profirovic J }}
*{{Cita publicación |título=Complete sequencing and characterization of 21,243 full-length human cDNAs |apellidos=Ota T |publicación=Nat. Genet. |volumen=36 |número=1 |páginas=40–5 |doi=10.1038/ng1285 |pmid=14702039 |apellidos3=Nishikawa T |apellidos4=Otsuki |nombre4=Tetsuji |apellidos5=Sugiyama |nombre5=Tomoyasu |apellidos6=Irie |nombre6=Ryotaro |apellidos7=Wakamatsu |nombre7=Ai |apellidos8=Hayashi |nombre8=Koji |apellidos9=Sato |nombre9=Hiroyuki |año=2004 |número-autores=3 |author2=Suzuki Y }}
*{{Cita publicación |título=A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels |apellidos=Doering CJ |publicación=J. Biol. Chem. |volumen=279 |número=28 |páginas=29709–17 |doi=10.1074/jbc.M308693200 |pmid=15105422 |apellidos3=Feng ZP |apellidos4=Arnot |nombre4=MI |apellidos5=Peloquin |nombre5=J |apellidos6=Hamid |nombre6=J |apellidos7=Barr |nombre7=W |apellidos8=Nirdosh |nombre8=A |apellidos9=Simms |nombre9=B |año=2004 |número-autores=3 |author2=Kisilevsky AE }}
{{refend}}

== Enlaces externos ==
{{Traducido ref|en|GNG2|oldid=}}
{{Control de autoridades}}

[[Categoría:Genes del cromosoma 14]]
[[Categoría:Genes del cromosoma 14]]

Revisión actual - 23:40 9 oct 2023

GNG2
Identificadores
Nomenclatura
 Otros nombres
Subunidad gamma-2 de la proteína de unión a nucleótidos de guanina.
Identificadores
externos
Locus Cr. 14 [1]
Estructura/Función proteica
Tamaño 71 (aminoácidos)
Funciones Modulador o transductor en varios sistemas de señalización.
Motivos Helix, Turn, Beta strand
Ortólogos
Especies
Humano Ratón
RefSeq
(proteína) NCBI
NP_001230702 n/a
[editar datos en Wikidata]

La subunidad gamma-2 de la proteína de unión a nucleótidos de guanina G(I) / G(S) / G(O) es una proteína que en los seres humanos está codificada por el gen GNG2 .[1]​[2]​[3]​[4]​

Las proteínas G heterotriméricas juegan un papel vital en las respuestas celulares a señales externas. La especificidad de una interacción proteína G-receptor está mediada principalmente por la subunidad gamma.[5]​

Función

[editar]

Las proteínas de unión a nucleótidos de guanina (proteínas G) participan como moduladores o transductores en varios sistemas de señalización transmembrana.[6]​ Las cadenas beta y gamma son necesarias para la actividad GTPasa, para la sustitución de GDP por GTP y para la interacción proteína G-efectora.[7]​

Referencias

[editar]
  1. ↑ «Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit». Biochem Biophys Res Commun 272 (2): 610-5. Jul 2000. PMID 10833460. doi:10.1006/bbrc.2000.2832. 
  2. ↑ «Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2». 
  3. ↑ «GNG2 Gene - GeneCards | GBG2 Protein | GBG2 Antibody». www.genecards.org. Consultado el 8 de marzo de 2021. 
  4. ↑ «OMIM Entry - * 606981 - GUANINE NUCLEOTIDE-BINDING PROTEIN, GAMMA-2; GNG2». www.omim.org (en inglés estadounidense). Consultado el 8 de marzo de 2021. 
  5. ↑ «Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2». 
  6. ↑ «GNG2 G protein subunit gamma 2 [Homo sapiens (human)] - Gene - NCBI». www.ncbi.nlm.nih.gov. Consultado el 8 de marzo de 2021. 
  7. ↑ «GNG2 - Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor - Homo sapiens (Human) - GNG2 gene & protein». www.uniprot.org (en inglés). Consultado el 8 de marzo de 2021. 

Bibliografía

[editar]

Enlaces externos

[editar]
Obtenido de «https://es.wikipedia.org/eswiki/w/index.php?title=GNG2&oldid=154490787»