Diferencia entre revisiones de «Vigabatrina»
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| ⚫ | '''Vigabatrina''' (ácido ''RS'')-4-aminohex-5-enoico) es un [[Anticonvulsivante|agente antiepiléptico]] que inhibe el [[catabolismo]] del [[ácido gamma-aminobutírico|GABA]] por inhibición de la [[transaminasa GABA]]. Es una [[análogo]] de GABA, pero no es un agonista del [[receptor]].<ref name=what_is_vigabatrin>Long, Phillip W. [http://www.mentalhealth.com/drug/p30-s07.html "Vigabatrin."] Internet Mental Health. 1995–2003.</ref> It is sold under the brand name '''Sabril'''. |
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| drug_name=Vigabatrin |
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| verifiedrevid = 402874222 |
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| IUPAC_name = (''RS'')-4-aminohex-5-enoic acid |
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| imagename = 1 : 1 mixture (racemate) |
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| width = 200 |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 5463 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = GR120KRT6K |
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| InChI = 1/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) |
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| InChIKey = PJDFLNIOAUIZSL-UHFFFAOYAL |
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| smiles = O=C(O)CCC(\C=C)N |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9) |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = PJDFLNIOAUIZSL-UHFFFAOYSA-N |
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| CAS_number = 60643-86-9 |
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| ATC_prefix = N03 |
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| ATC_suffix = AG04 |
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| ATC_supplemental = |
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| PubChem = 5665 |
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| DrugBank = APRD00282 |
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| C = 6 | H = 11 | N = 1 | O = 2 |
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| molecular_weight = 129.157 g/mol |
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| bioavailability = 80–90% |
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| protein_bound = Nil |
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| metabolism = Almost no metabolic transformation occurs |
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| elimination_half-life = 5–8 hours in young adults, 12–13 hours in the elderly. |
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| pregnancy_AU = D |
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| legal_status = Not a controlled substance |
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| routes_of_administration = Oral |
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| excretion = [[Renal]] |
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==Indicaciones== |
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| ⚫ | '''Vigabatrina''' es un [[Anticonvulsivante|agente |
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{{en obras}} |
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==Indications== |
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===Epilepsia=== |
===Epilepsia=== |
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{{listaref|2}} |
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[[Categoría:Anticonvulsivantes]] |
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Revisión del 18:35 3 ene 2011
Vigabatrina (ácido RS)-4-aminohex-5-enoico) es un agente antiepiléptico que inhibe el catabolismo del GABA por inhibición de la transaminasa GABA. Es una análogo de GABA, pero no es un agonista del receptor.[1] It is sold under the brand name Sabril.
Indicaciones
Epilepsia
- ↑ Long, Phillip W. "Vigabatrin." Internet Mental Health. 1995–2003.