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L-艾杜糖醇2-脱氢酶:修订间差异

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{{DISPLAYTITLE:<small>L</small>-艾杜糖醇2-脱氢酶}}
{{enzyme
{{enzyme
| Name = L-艾杜糖醇2-脱氢酶
| Name = <small>L</small>-艾杜糖醇2-脱氢酶
| Systematic_name = L-iditol:NAD<sup>+</sup> 2-oxidoreductase
| Systematic_name = <small>L</small>-iditol:NAD<sup>+</sup> 2-oxidoreductase
| Acronym =
| Acronym =
| Other_names = polyol dehydrogenase; sorbitol dehydrogenase; L-iditol:NAD<sup>+</sup> 5-oxidoreductase; L-iditol (sorbitol) dehydrogenase; glucitol dehydrogenase; L-iditol:NAD<sup>+</sup> oxidoreductase; NAD<sup>+</sup>-dependent sorbitol dehydrogenase; NAD<sup>+</sup>-sorbitol dehydrogenase
| Other_names = polyol dehydrogenase; sorbitol dehydrogenase; <small>L</small>-iditol:NAD<sup>+</sup> 5-oxidoreductase; <small>L</small>-iditol (sorbitol) dehydrogenase; glucitol dehydrogenase; <small>L</small>-iditol:NAD<sup>+</sup> oxidoreductase; NAD<sup>+</sup>-dependent sorbitol dehydrogenase; NAD<sup>+</sup>-sorbitol dehydrogenase
| EC_number = 1.1.1.14
| EC_number = 1.1.1.14
| CAS_number = 9028-21-1 | IUBMB_EC_number = 1/1/1/14 | GO_code = 0003939 | image =
| CAS_number = 9028-21-1
| IUBMB_EC_number = 1/1/1/14
| GO_code = 0003939
| image = 1pl8.jpg
| width =
| width = 270
| caption =
| caption =
}}
}}
'''L-艾杜糖醇2-脱氢酶'''({{lang-en|L-iditol 2-dehydrogenase}},[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.14 1.1.1.14])是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]:
'''<small>L</small>-艾杜糖醇2-脱氢酶'''({{lang-en|<small>L</small>-iditol 2-dehydrogenase}},[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.14 1.1.1.14] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.14 |date=20200228193854 }})是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]:


:[[L-艾杜糖醇]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> [[L-山梨糖]] + NADH + [[氢离子|H<sup>+</sup>]]
:[[L-艾杜糖醇|<small>L</small>-艾杜糖醇]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> [[L-山梨糖|<small>L</small>-山梨糖]] + NADH + [[氢离子|H<sup>+</sup>]]


L-艾杜糖醇2-脱氢酶广泛存在于各种[[生物]][[细胞]]中,现已在[[古菌]]、[[细菌]]、[[真菌]]、[[植物]]和[[动物]]细胞中发现了这种酶。L-艾杜糖醇2-脱氢酶可以作用于包括L-艾杜糖醇、[[D-葡萄糖醇]]、[[D-木糖醇]]和[[D-半乳糖醇]](D-卫矛醇)等[[糖醇]][[分子]]。不同生物不同[[组织 (生物学)|组织]]中的L-艾杜糖醇2-脱氢酶对不同的[[底物]]具有特异性。L-艾杜糖醇2-脱氢酶对能特异性识别NAD<sup>+</sup>,但不能利用NADP<sup>+</sup>。这种酶主要参与[[果糖]]和[[甘露糖]]之间的转化过程。
<small>L</small>-艾杜糖醇2-脱氢酶广泛存在于各种[[生物]][[细胞]]中,现已在[[古菌]]、[[细菌]]、[[真菌]]、[[植物]]和[[动物]]细胞中发现了这种酶。<small>L</small>-艾杜糖醇2-脱氢酶可以作用于包括<small>L</small>-艾杜糖醇、[[D-葡萄糖醇|<small>D</small>-葡萄糖醇]]、[[D-木糖醇|<small>D</small>-木糖醇]]和[[D-半乳糖醇|<small>D</small>-半乳糖醇]](<small>D</small>-卫矛醇)等[[糖醇]][[分子]]。不同生物不同[[组织 (生物学)|组织]]中的<small>L</small>-艾杜糖醇2-脱氢酶对不同的[[底物]]具有特异性。<small>L</small>-艾杜糖醇2-脱氢酶对能特异性识别NAD<sup>+</sup>,但不能利用NADP<sup>+</sup>。这种酶主要参与[[果糖]]和[[甘露糖]]之间的转化过程。


== 参考文献 ==
== 参考文献 ==
{{refbegin}}
{{refbegin}}
{{reflist}}
{{reflist}}
* {{cite journal | author = Bailey JP, Renz C and McGuinness ET | year = 1981 | title = Sorbitol dehydrogenase from horse liver: purification, characterization and comparative properties | journal = Comp. Biochem. Physiol. | volume = 69B | pages = 909&ndash;914 }}{{Wordbreak}}* {{cite journal | author = Burnell JN, Holmes RS | year = 1983 | title = Purification and properties of sorbitol dehydrogenase from mouse liver | journal = Int. J. Biochem. | volume = 15 | pages = 507&ndash;11 | pmid = 6852349 | doi = 10.1016/0020-711X(83)90124-6 | issue = 4 }}{{Wordbreak}}* {{cite journal | author = Leissing N, McGuinness ET | year = 1978 | title = Rapid affinity purification and properties of rat liver sorbitol dehydrogenase | journal = Biochim. Biophys. Acta. | volume = 524 | pages = 254&ndash;61 | pmid = 667078 | issue = 2 }}{{Wordbreak}}* {{cite journal | author = Negm FB and Loescher WH | year = 1979 | title = Detection and Characterization of Sorbitol Dehydrogenase from Apple Callus Tissue | journal = Plant Physiol. | volume = 64 | pages = 69&ndash;73 | doi = 10.1104/pp.64.1.69 | pmid=16660917 | issue = 1 | pmc = 543026}}{{Wordbreak}}* {{cite journal | author = O'Brien MM, Schofield PJ, Edwards MR | year = 1983 | title = Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase | journal = Biochem. J. | volume = 211 | pages = 81&ndash;90 | pmid = 6870831 | issue = 1 | pmc = 1154331 }}
* {{cite journal | author = Bailey JP, Renz C and McGuinness ET | year = 1981 | title = Sorbitol dehydrogenase from horse liver: purification, characterization and comparative properties | journal = Comp. Biochem. Physiol. | volume = 69B | pages = 909–914 }}
* {{cite journal | author = Burnell JN, Holmes RS | year = 1983 | title = Purification and properties of sorbitol dehydrogenase from mouse liver | journal = Int. J. Biochem. | volume = 15 | pages = 507–11 | pmid = 6852349 | doi = 10.1016/0020-711X(83)90124-6 | issue = 4 }}
* {{cite journal | author = Leissing N, McGuinness ET | year = 1978 | title = Rapid affinity purification and properties of rat liver sorbitol dehydrogenase | journal = Biochim. Biophys. Acta. | volume = 524 | pages = 254–61 | pmid = 667078 | issue = 2 }}
* {{cite journal | author = Negm FB and Loescher WH | year = 1979 | title = Detection and Characterization of Sorbitol Dehydrogenase from Apple Callus Tissue | url = https://archive.org/details/sim_plant-physiology_1979-07_64_1/page/n74 | journal = Plant Physiol. | volume = 64 | pages = 69–73 | doi = 10.1104/pp.64.1.69 | pmid=16660917 | issue = 1 | pmc = 543026}}
* {{cite journal | author = O'Brien MM, Schofield PJ, Edwards MR | year = 1983 | title = Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase | journal = Biochem. J. | volume = 211 | pages = 81–90 | pmid = 6870831 | issue = 1 | pmc = 1154331 }}
{{refend}}
{{refend}}


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[[Category:NADH依赖性酶]]
[[Category:NADH依赖性酶]]
[[Category:已知结构的酶]]
[[Category:已知结构的酶]]

[[en:L-iditol 2-dehydrogenase]]
[[it:L-iditolo 2-deidrogenasi]]
[[ja:L-イジトール-2-デヒドロゲナーゼ]]

2021年10月17日 (日) 21:02的最新版本

L-艾杜糖醇2-脱氢酶
识别码
EC編號 1.1.1.14
CAS号 9028-21-1
数据库
IntEnz IntEnz浏览
BRENDA英语BRENDA BRENDA入口
ExPASy英语ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc英语MetaCyc 代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本体 AmiGO / EGO

L-艾杜糖醇2-脱氢酶(英語:L-iditol 2-dehydrogenaseEC 1.1.1.14页面存档备份,存于互联网档案馆))是一种以NAD+NADP+受体、作用于供体CH-OH基团上的氧化还原酶。这种催化以下酶促反应

L-艾杜糖醇 + NAD+ L-山梨糖 + NADH + H+

L-艾杜糖醇2-脱氢酶广泛存在于各种生物细胞中,现已在古菌细菌真菌植物动物细胞中发现了这种酶。L-艾杜糖醇2-脱氢酶可以作用于包括L-艾杜糖醇、D-葡萄糖醇D-木糖醇D-半乳糖醇D-卫矛醇)等糖醇分子。不同生物不同组织中的L-艾杜糖醇2-脱氢酶对不同的底物具有特异性。L-艾杜糖醇2-脱氢酶对能特异性识别NAD+,但不能利用NADP+。这种酶主要参与果糖甘露糖之间的转化过程。

参考文献

[编辑]