L-艾杜糖醇2-脱氢酶:修订间差异
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{{DISPLAYTITLE:<small>L</small>-艾杜糖醇2-脱氢酶}} |
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{{enzyme |
{{enzyme |
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| Name = L-艾杜糖醇2-脱氢酶 |
| Name = <small>L</small>-艾杜糖醇2-脱氢酶 |
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| Systematic_name = L-iditol:NAD<sup>+</sup> 2-oxidoreductase |
| Systematic_name = <small>L</small>-iditol:NAD<sup>+</sup> 2-oxidoreductase |
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| Acronym = |
| Acronym = |
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| Other_names = polyol dehydrogenase; sorbitol dehydrogenase; L-iditol:NAD<sup>+</sup> 5-oxidoreductase; L-iditol (sorbitol) dehydrogenase; glucitol dehydrogenase; L-iditol:NAD<sup>+</sup> oxidoreductase; NAD<sup>+</sup>-dependent sorbitol dehydrogenase; NAD<sup>+</sup>-sorbitol dehydrogenase |
| Other_names = polyol dehydrogenase; sorbitol dehydrogenase; <small>L</small>-iditol:NAD<sup>+</sup> 5-oxidoreductase; <small>L</small>-iditol (sorbitol) dehydrogenase; glucitol dehydrogenase; <small>L</small>-iditol:NAD<sup>+</sup> oxidoreductase; NAD<sup>+</sup>-dependent sorbitol dehydrogenase; NAD<sup>+</sup>-sorbitol dehydrogenase |
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| EC_number = 1.1.1.14 |
| EC_number = 1.1.1.14 |
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| CAS_number = 9028-21-1 | IUBMB_EC_number = 1/1/1/14 | GO_code = 0003939 | image = |
| CAS_number = 9028-21-1 |
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| IUBMB_EC_number = 1/1/1/14 |
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| GO_code = 0003939 |
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| image = 1pl8.jpg |
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| width = |
| width = 270 |
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}} |
}} |
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'''L-艾杜糖醇2-脱氢酶'''({{lang-en|L-iditol 2-dehydrogenase}},[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.14 1.1.1.14])是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]: |
'''<small>L</small>-艾杜糖醇2-脱氢酶'''({{lang-en|<small>L</small>-iditol 2-dehydrogenase}},[[EC编号|EC]] [http://enzyme.expasy.org/EC/1.1.1.14 1.1.1.14] {{Wayback|url=http://enzyme.expasy.org/EC/1.1.1.14 |date=20200228193854 }})是一种以[[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]]或[[烟酰胺腺嘌呤二核苷酸磷酸|NADP<sup>+</sup>]]为[[受体 (生物化学)|受体]]、作用于[[供体]][[次甲基|CH]]-[[羟基|OH]][[基团]]上的[[氧化还原酶]]。这种[[酶]]能[[催化]]以下[[酶促反应]]: |
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:[[L-艾杜糖醇]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> [[L-山梨糖]] + NADH + [[氢离子|H<sup>+</sup>]] |
:[[L-艾杜糖醇|<small>L</small>-艾杜糖醇]] + [[烟酰胺腺嘌呤二核苷酸|NAD<sup>+</sup>]] <math>\rightleftharpoons</math> [[L-山梨糖|<small>L</small>-山梨糖]] + NADH + [[氢离子|H<sup>+</sup>]] |
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L-艾杜糖醇2-脱氢酶广泛存在于各种[[生物]][[细胞]]中,现已在[[古菌]]、[[细菌]]、[[真菌]]、[[植物]]和[[动物]]细胞中发现了这种酶。L-艾杜糖醇2-脱氢酶可以作用于包括L-艾杜糖醇、[[D-葡萄糖醇]]、[[D-木糖醇]]和[[D-半乳糖醇]] |
<small>L</small>-艾杜糖醇2-脱氢酶广泛存在于各种[[生物]][[细胞]]中,现已在[[古菌]]、[[细菌]]、[[真菌]]、[[植物]]和[[动物]]细胞中发现了这种酶。<small>L</small>-艾杜糖醇2-脱氢酶可以作用于包括<small>L</small>-艾杜糖醇、[[D-葡萄糖醇|<small>D</small>-葡萄糖醇]]、[[D-木糖醇|<small>D</small>-木糖醇]]和[[D-半乳糖醇|<small>D</small>-半乳糖醇]](<small>D</small>-卫矛醇)等[[糖醇]][[分子]]。不同生物不同[[组织 (生物学)|组织]]中的<small>L</small>-艾杜糖醇2-脱氢酶对不同的[[底物]]具有特异性。<small>L</small>-艾杜糖醇2-脱氢酶对能特异性识别NAD<sup>+</sup>,但不能利用NADP<sup>+</sup>。这种酶主要参与[[果糖]]和[[甘露糖]]之间的转化过程。 |
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== 参考文献 == |
== 参考文献 == |
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* {{cite journal | author = Bailey JP, Renz C and McGuinness ET | year = 1981 | title = Sorbitol dehydrogenase from horse liver: purification, characterization and comparative properties | journal = Comp. Biochem. Physiol. | volume = 69B | pages = |
* {{cite journal | author = Bailey JP, Renz C and McGuinness ET | year = 1981 | title = Sorbitol dehydrogenase from horse liver: purification, characterization and comparative properties | journal = Comp. Biochem. Physiol. | volume = 69B | pages = 909–914 }} |
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* {{cite journal | author = Burnell JN, Holmes RS | year = 1983 | title = Purification and properties of sorbitol dehydrogenase from mouse liver | journal = Int. J. Biochem. | volume = 15 | pages = 507–11 | pmid = 6852349 | doi = 10.1016/0020-711X(83)90124-6 | issue = 4 }} |
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* {{cite journal | author = Leissing N, McGuinness ET | year = 1978 | title = Rapid affinity purification and properties of rat liver sorbitol dehydrogenase | journal = Biochim. Biophys. Acta. | volume = 524 | pages = 254–61 | pmid = 667078 | issue = 2 }} |
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* {{cite journal | author = Negm FB and Loescher WH | year = 1979 | title = Detection and Characterization of Sorbitol Dehydrogenase from Apple Callus Tissue | url = https://archive.org/details/sim_plant-physiology_1979-07_64_1/page/n74 | journal = Plant Physiol. | volume = 64 | pages = 69–73 | doi = 10.1104/pp.64.1.69 | pmid=16660917 | issue = 1 | pmc = 543026}} |
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* {{cite journal | author = O'Brien MM, Schofield PJ, Edwards MR | year = 1983 | title = Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase | journal = Biochem. J. | volume = 211 | pages = 81–90 | pmid = 6870831 | issue = 1 | pmc = 1154331 }} |
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{{refend}} |
{{refend}} |
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[[Category:NADH依赖性酶]] |
[[Category:NADH依赖性酶]] |
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[[Category:已知结构的酶]] |
[[Category:已知结构的酶]] |
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[[en:L-iditol 2-dehydrogenase]] |
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[[it:L-iditolo 2-deidrogenasi]] |
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[[ja:L-イジトール-2-デヒドロゲナーゼ]] |
2021年10月17日 (日) 21:02的最新版本
L-艾杜糖醇2-脱氢酶 | |||||||||
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识别码 | |||||||||
EC編號 | 1.1.1.14 | ||||||||
CAS号 | 9028-21-1 | ||||||||
数据库 | |||||||||
IntEnz | IntEnz浏览 | ||||||||
BRENDA | BRENDA入口 | ||||||||
ExPASy | NiceZyme浏览 | ||||||||
KEGG | KEGG入口 | ||||||||
MetaCyc | 代谢路径 | ||||||||
PRIAM | 概述 | ||||||||
PDB | RCSB PDB PDBj PDBe PDBsum | ||||||||
基因本体 | AmiGO / EGO | ||||||||
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L-艾杜糖醇2-脱氢酶(英語:L-iditol 2-dehydrogenase,EC 1.1.1.14 (页面存档备份,存于互联网档案馆))是一种以NAD+或NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应:
L-艾杜糖醇2-脱氢酶广泛存在于各种生物细胞中,现已在古菌、细菌、真菌、植物和动物细胞中发现了这种酶。L-艾杜糖醇2-脱氢酶可以作用于包括L-艾杜糖醇、D-葡萄糖醇、D-木糖醇和D-半乳糖醇(D-卫矛醇)等糖醇分子。不同生物不同组织中的L-艾杜糖醇2-脱氢酶对不同的底物具有特异性。L-艾杜糖醇2-脱氢酶对能特异性识别NAD+,但不能利用NADP+。这种酶主要参与果糖和甘露糖之间的转化过程。
参考文献
[编辑]- Bailey JP, Renz C and McGuinness ET. Sorbitol dehydrogenase from horse liver: purification, characterization and comparative properties. Comp. Biochem. Physiol. 1981, 69B: 909–914.
- Burnell JN, Holmes RS. Purification and properties of sorbitol dehydrogenase from mouse liver. Int. J. Biochem. 1983, 15 (4): 507–11. PMID 6852349. doi:10.1016/0020-711X(83)90124-6.
- Leissing N, McGuinness ET. Rapid affinity purification and properties of rat liver sorbitol dehydrogenase. Biochim. Biophys. Acta. 1978, 524 (2): 254–61. PMID 667078.
- Negm FB and Loescher WH. Detection and Characterization of Sorbitol Dehydrogenase from Apple Callus Tissue. Plant Physiol. 1979, 64 (1): 69–73. PMC 543026 . PMID 16660917. doi:10.1104/pp.64.1.69.
- O'Brien MM, Schofield PJ, Edwards MR. Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase. Biochem. J. 1983, 211 (1): 81–90. PMC 1154331 . PMID 6870831.