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ICBP43:修订间差异

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'''{{PAGENAME}}'''是43种[[人类]][[乳腺癌]][[细胞系]]的列表<ref>{{cite web |title=ICBP43 cell lines - HMS LINCS Project |url=https://lincs.hms.harvard.edu/about/approach/reagents/icbp43/ |website=lincs.hms.harvard.edu}}</ref>,由[[国家癌症研究所]]的“癌症生物学综合计划”('''I'''ntegrative '''C'''ancer '''B'''iology '''P'''rogram)列出<ref>{{cite web |title=Reagents - HMS LINCS Project |url=https://lincs.hms.harvard.edu/about/approach/reagents/ |website=lincs.hms.harvard.edu}}</ref>,用于[[药物筛选]]等许多生物[[医学研究]]<ref>{{cite journal |last1=Anderson |first1=Alexander R. A. |last2=Tomlin |first2=Claire J. |last3=Couch |first3=Jennifer |last4=Gallahan |first4=Dan |title=Mathematics of the Integrative Cancer Biology Program |journal=Interface Focus |date=2013-08-06 |volume=3 |issue=4 |pages=20130023 |doi=10.1098/RSFS.2013.0023}}</ref>。
'''{{PAGENAME}}'''是43种[[人类]][[乳腺癌]][[细胞系]]的列表<ref>{{cite web |title=ICBP43 cell lines - HMS LINCS Project |url=https://lincs.hms.harvard.edu/about/approach/reagents/icbp43/ |website=lincs.hms.harvard.edu |access-date=2024-02-03 |archive-date=2024-01-31 |archive-url=https://web.archive.org/web/20240131162103/https://lincs.hms.harvard.edu/about/approach/reagents/icbp43/ |dead-url=no }}</ref>,由美国[[国家癌症研究所]]的“癌症生物学综合计划”('''I'''ntegrative '''C'''ancer '''B'''iology '''P'''rogram)列出<ref>{{cite web |title=Reagents - HMS LINCS Project |url=https://lincs.hms.harvard.edu/about/approach/reagents/ |website=lincs.hms.harvard.edu |access-date=2024-02-03 |archive-date=2024-01-31 |archive-url=https://web.archive.org/web/20240131162105/https://lincs.hms.harvard.edu/about/approach/reagents/ |dead-url=no }}</ref>,用于[[药物筛选]]等许多生物[[医学研究]]<ref>{{cite journal |last1=Anderson |first1=Alexander R. A. |last2=Tomlin |first2=Claire J. |last3=Couch |first3=Jennifer |last4=Gallahan |first4=Dan |title=Mathematics of the Integrative Cancer Biology Program |journal=Interface Focus |date=2013-08-06 |volume=3 |issue=4 |pages=20130023 |doi=10.1098/RSFS.2013.0023}}</ref>。


==细胞系==
==细胞系==
===[[三阴性乳腺癌]]===
===[[三阴性乳腺癌]]===
{| class="wikitable sortable"
{| class="wikitable sortable"
! 细胞系 !! 文献 !! 外部链接
! 细胞系 !! 倍增时间 !! 转录亚型 !! ATCC ID !! 文献 !! 外部链接
|-
|-
| [[MDA-MB-231]] || <ref>{{cite journal |last1=Cailleau |first1=R |last2=Young |first2=R |last3=Olivé |first3=M |last4=Reeves WJ |first4=Jr |title=Breast tumor cell lines from pleural effusions. |journal=Journal of the National Cancer Institute |date=1974-09 |volume=53 |issue=3 |pages=661-74 |doi=10.1093/jnci/53.3.661 |pmid=4412247}}</ref> || [https://www.cellosaurus.org/CVCL_0062 CVCL_0062]
| [[BT-20細胞|BT-20]] || 66.15h || Basal || HTB-19 || <ref>{{cite journal |last1=Chavez |first1=KJ |last2=Garimella |first2=SV |last3=Lipkowitz |first3=S |title=Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer. |journal=Breast disease |date=2010 |volume=32 |issue=1-2 |pages=35-48 |doi=10.3233/BD-2010-0307 |pmid=21778573 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/21778573/ |accessdate=2019-12-04}}</ref> || [https://www.cellosaurus.org/CVCL_0178 CVCL_0178] {{Wayback|url=https://www.cellosaurus.org/CVCL_0178 |date=20240222081245 }}
|-
|-
| [[MDA-MB-468]] || <ref>{{cite journal |last1=Cailleau |first1=R |last2=Olivé |first2=M |last3=Cruciger |first3=QV |title=Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization. |journal=In vitro |date=1978-11 |volume=14 |issue=11 |pages=911-5 |doi=10.1007/bf02616120 |pmid=730202 |url=https://pubmed.ncbi.nlm.nih.gov/730202-long-term-human-breast-carcinoma-cell-lines-of-metastatic-origin-preliminary-characterization/ |accessdate=2020-02-14 |author= |archive-url=https://web.archive.org/web/20200214054654/https://pubmed.ncbi.nlm.nih.gov/730202-long-term-human-breast-carcinoma-cell-lines-of-metastatic-origin-preliminary-characterization/ |archive-date=2020-02-14 |dead-url=yes }}</ref> || [https://www.cellosaurus.org/CVCL_0419 CVCL_0419]
| [[MDA-MB-231]] || 41.9h || Claudin-low || HTB-26 || <ref>{{cite journal |last1=Cailleau |first1=R |last2=Young |first2=R |last3=Olivé |first3=M |last4=Reeves WJ |first4=Jr |title=Breast tumor cell lines from pleural effusions. |url=https://archive.org/details/sim_journal-of-the-national-cancer-institute_1974-09_53_3/page/661 |journal=Journal of the National Cancer Institute |date=1974-09 |volume=53 |issue=3 |pages=661-74 |doi=10.1093/jnci/53.3.661 |pmid=4412247}}</ref> || [https://www.cellosaurus.org/CVCL_0062 CVCL_0062] {{Wayback|url=https://www.cellosaurus.org/CVCL_0062 |date=20240419183323 }}
|-
|-
| [[MDA-MB-468]] || 62h || Basal || HTB-132 || <ref name=MDA-MB>{{cite journal |last1=Cailleau |first1=R |last2=Olivé |first2=M |last3=Cruciger |first3=QV |title=Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization. |journal=In vitro |date=1978-11 |volume=14 |issue=11 |pages=911-5 |doi=10.1007/bf02616120 |pmid=730202 |url=https://pubmed.ncbi.nlm.nih.gov/730202-long-term-human-breast-carcinoma-cell-lines-of-metastatic-origin-preliminary-characterization/ |accessdate=2020-02-14 |author= |archive-url=https://web.archive.org/web/20200214054654/https://pubmed.ncbi.nlm.nih.gov/730202-long-term-human-breast-carcinoma-cell-lines-of-metastatic-origin-preliminary-characterization/ |archive-date=2020-02-14 |dead-url=yes }}</ref> || [https://www.cellosaurus.org/CVCL_0419 CVCL_0419] {{Wayback|url=https://www.cellosaurus.org/CVCL_0419 |date=20231208083908 }}
| [[Hs 578T]] || <ref name=578T>{{cite journal |last1=Hackett |first1=AJ |last2=Smith |first2=HS |last3=Springer |first3=EL |last4=Owens |first4=RB |last5=Nelson-Rees |first5=WA |last6=Riggs |first6=JL |last7=Gardner |first7=MB |title=Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines. |journal=Journal of the National Cancer Institute |date=1977-06 |volume=58 |issue=6 |pages=1795-806 |doi=10.1093/jnci/58.6.1795 |pmid=864756}}</ref> || [https://www.cellosaurus.org/CVCL_0332 CVCL_0332]
|-
|-
| [[BT-549]] || <ref name=aa>{{cite journal |last1=Lasfargues |first1=EY |last2=Coutinho |first2=WG |last3=Redfield |first3=ES |title=Isolation of two human tumor epithelial cell lines from solid breast carcinomas. |journal=Journal of the National Cancer Institute |date=1978-10 |volume=61 |issue=4 |pages=967-78 |pmid=212572 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/212572/ |accessdate=2019-12-07 |archive-date=2013-12-17 |archive-url=https://web.archive.org/web/20131217012712/http://www.ncbi.nlm.nih.gov/m/pubmed/212572/ |dead-url=no }}</ref> || [https://www.cellosaurus.org/CVCL_1092 CVCL_1092]
| [[Hs 578T]] || 53.8h || Claudin-low || HTB-126 || <ref name=578T>{{cite journal |last1=Hackett |first1=AJ |last2=Smith |first2=HS |last3=Springer |first3=EL |last4=Owens |first4=RB |last5=Nelson-Rees |first5=WA |last6=Riggs |first6=JL |last7=Gardner |first7=MB |title=Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines. |url=https://archive.org/details/sim_journal-of-the-national-cancer-institute_1977-06_58_6/page/1795 |journal=Journal of the National Cancer Institute |date=1977-06 |volume=58 |issue=6 |pages=1795-806 |doi=10.1093/jnci/58.6.1795 |pmid=864756}}</ref> || [https://www.cellosaurus.org/CVCL_0332 CVCL_0332] {{Wayback|url=https://www.cellosaurus.org/CVCL_0332 |date=20230408070505 }}
|-
| [[BT-549]] || 53.9h || Claudin-low || HTB-122 || <ref name=aa>{{cite journal |last1=Lasfargues |first1=EY |last2=Coutinho |first2=WG |last3=Redfield |first3=ES |title=Isolation of two human tumor epithelial cell lines from solid breast carcinomas. |journal=Journal of the National Cancer Institute |date=1978-10 |volume=61 |issue=4 |pages=967-78 |pmid=212572 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/212572/ |accessdate=2019-12-07 |archive-date=2013-12-17 |archive-url=https://web.archive.org/web/20131217012712/http://www.ncbi.nlm.nih.gov/m/pubmed/212572/ |dead-url=no }}</ref> || [https://www.cellosaurus.org/CVCL_1092 CVCL_1092] {{Wayback|url=https://www.cellosaurus.org/CVCL_1092 |date=20240221145258 }}
|-
| [[184B5]] || 56.15h || Basal || CRL-8799 || <ref name="184B5">{{cite journal |last1=Stampfer |first1=MR |last2=Bartley |first2=JC |title=Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene. |journal=Proceedings of the National Academy of Sciences of the United States of America |date=1985-04 |volume=82 |issue=8 |pages=2394-8 |doi=10.1073/pnas.82.8.2394 |pmid=3857588}}</ref> || [https://www.cellosaurus.org/CVCL_4688 CVCL_4688] {{Wayback|url=https://www.cellosaurus.org/CVCL_4688 |date=20240415235157 }}
|-
| [[DU4475]] || 90h || ? || HTB-123 || <ref>{{cite journal |last1=Langlois |first1=AJ |last2=Holder WD |first2=Jr |last3=Iglehart |first3=JD |last4=Nelson-Rees |first4=WA |last5=Wells SA |first5=Jr |last6=Bolognesi |first6=DP |title=Morphological and biochemical properties of a new human breast cancer cell line. |journal=Cancer research |date=1979-07 |volume=39 |issue=7 Pt 1 |pages=2604-13 |pmid=221108}}</ref> || [https://www.cellosaurus.org/CVCL_1183 CVCL_1183] {{Wayback|url=https://www.cellosaurus.org/CVCL_1183 |date=20240222072240 }}
|-
| [[HCC38]] || 50.98h || Claudin-low || CRL-2314 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1267 CVCL_1267] {{Wayback|url=https://www.cellosaurus.org/CVCL_1267 |date=20240207073905 }}
|-
| [[HCC70]] || 67.80h || Basal || CRL-2315 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1270 CVCL_1270] {{Wayback|url=https://www.cellosaurus.org/CVCL_1270 |date=20240519024029 }}
|-
| [[HCC1187]] || 69.35h || Basal || CRL-2322 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1247 CVCL_1247] {{Wayback|url=https://www.cellosaurus.org/CVCL_1247 |date=20240207073907 }}
|-
| [[HCC1395]] || 84.07h || Claudin-low || CRL-2324 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1249 CVCL_1349] {{Wayback|url=https://www.cellosaurus.org/CVCL_1249 |date=20240207073915 }}
|-
| [[HCC1599]] || 4-5d || Basal || CRL-2331 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1256 CVCL_1256] {{Wayback|url=https://www.cellosaurus.org/CVCL_1256 |date=20240207073912 }}
|-
| [[HCC1806]] || 36.66h ||Basal || CRL-2335 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1258 CVCL_1258] {{Wayback|url=https://www.cellosaurus.org/CVCL_1258 |date=20240510041610 }}
|-
| [[HCC1937]] || 53.49h || Basal || CRL-2336 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_0290 CVCL_0290] {{Wayback|url=https://www.cellosaurus.org/CVCL_0290 |date=20240506115556 }}
|-
| [[HCC2157]] || ? || ? || CRL-2340 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1261 CVCL_1261] {{Wayback|url=https://www.cellosaurus.org/CVCL_1261 |date=20240208004607 }}
|-
| [[MDA-MB-157]] || 66.98h || Claudin-low || HTB-24 || <ref name=MDA-MB/> || [https://www.cellosaurus.org/CVCL_0618 CVCL_0618] {{Wayback|url=https://www.cellosaurus.org/CVCL_0618 |date=20240424051823 }}
|-
| [[MDA-MB-436]] || 89.31h || Claudin-low || HTB-130 || <ref name=MDA-MB/> || [https://www.cellosaurus.org/CVCL_0623 CVCL_0623] {{Wayback|url=https://www.cellosaurus.org/CVCL_0623 |date=20240214135352 }}
|-
| [[MDA-MB-453]] || 62.49h || Luminal || HTB-131 || <ref name=Hall>{{cite journal |last1=Hall |first1=RE |last2=Birrell |first2=SN |last3=Tilley |first3=WD |last4=Sutherland |first4=RL |title=MDA-MB-453, an androgen-responsive human breast carcinoma cell line with high level androgen receptor expression. |journal=European journal of cancer (Oxford, England : 1990) |date=1994 |volume=30A |issue=4 |pages=484-90 |doi=10.1016/0959-8049(94)90424-3 |pmid=8018407 |url=https://pubmed.ncbi.nlm.nih.gov/8018407-mda-mb-453-an-androgen-responsive-human-breast-carcinoma-cell-line-with-high-level-androgen-receptor-expression/ |accessdate=2020-02-14 }}{{Dead link|date=2020年5月 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> || [https://www.cellosaurus.org/CVCL_0418 CVCL_0418] {{Wayback|url=https://www.cellosaurus.org/CVCL_0418 |date=20240426133149 }}
|-
|-
|}
|}

===HR+===
===HR+===
{| class="wikitable sortable"
{| class="wikitable sortable"
! 细胞系 !! 文献 !! 外部链接
! 细胞系 !! 倍增时间 !! 转录亚型 !! ATCC ID !! 文献 !! 外部链接
|-
|-
| [[MCF-7]] || <ref>{{cite journal|journal=Journal of the National Cancer Institute|volume=107|issue=7|pages=djv073|date=1 July 2015|doi=10.1093/jnci/djv073|pmid = 25828948|first1=Adrian V. |last1=Lee|display-authors=etal|title=MCF-7 Cells—Changing the Course of Breast Cancer Research and Care for 45 Years}}</ref> || [https://www.cellosaurus.org/CVCL_0031 CVCL_0031]
| [[MCF-7]] || 25.4h || Luminal || HTB-22 || <ref>{{cite journal|journal=Journal of the National Cancer Institute|volume=107|issue=7|pages=djv073|date=1 July 2015|doi=10.1093/jnci/djv073|pmid = 25828948|first1=Adrian V. |last1=Lee|display-authors=etal|title=MCF-7 Cells—Changing the Course of Breast Cancer Research and Care for 45 Years}}</ref> || [https://www.cellosaurus.org/CVCL_0031 CVCL_0031] {{Wayback|url=https://www.cellosaurus.org/CVCL_0031 |date=20171130124009 }}
|-
|-
| [[T-47D細胞|T-47D]] || <ref>{{cite journal |last1=Yu |first1=S |last2=Kim |first2=T |last3=Yoo |first3=KH |last4=Kang |first4=K |title=The T47D cell line is an ideal experimental model to elucidate the progesterone-specific effects of a luminal A subtype of breast cancer. |journal=Biochemical and biophysical research communications |date=2017-05-06 |volume=486 |issue=3 |pages=752-758 |doi=10.1016/j.bbrc.2017.03.114 |pmid=28342866 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/28342866/ |accessdate=2019-11-30}}</ref> || [https://www.cellosaurus.org/CVCL_0553 CVCL_0553]
| [[T-47D細胞|T-47D]] || 45.5h || Luminal || HTB-133 || <ref>{{cite journal |last1=Yu |first1=S |last2=Kim |first2=T |last3=Yoo |first3=KH |last4=Kang |first4=K |title=The T47D cell line is an ideal experimental model to elucidate the progesterone-specific effects of a luminal A subtype of breast cancer. |journal=Biochemical and biophysical research communications |date=2017-05-06 |volume=486 |issue=3 |pages=752-758 |doi=10.1016/j.bbrc.2017.03.114 |pmid=28342866 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/28342866/ |accessdate=2019-11-30}}</ref> || [https://www.cellosaurus.org/CVCL_0553 CVCL_0553] {{Wayback|url=https://www.cellosaurus.org/CVCL_0553 |date=20240501134215 }}
|-
| [[BT-483]] || 140.00h || Luminal || HTB-121 || <ref>{{cite journal |last1=Lasfargues |first1=EY |last2=Coutinho |first2=WG |last3=Redfield |first3=ES |title=Isolation of two human tumor epithelial cell lines from solid breast carcinomas. |journal=Journal of the National Cancer Institute |date=1978-10 |volume=61 |issue=4 |pages=967-78 |pmid=212572 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/212572/ |accessdate=2019-12-07 |archive-date=2013-12-17 |archive-url=https://web.archive.org/web/20131217012712/http://www.ncbi.nlm.nih.gov/m/pubmed/212572/ |dead-url=no }}</ref> || [https://www.cellosaurus.org/CVCL_2319 CVCL_2319] {{Wayback|url=https://www.cellosaurus.org/CVCL_2319 |date=20240203181345 }}
|-
| [[CAMA-1]] || 72.94h || Luminal || HTB-21 || <ref>{{cite journal |last1=Kerbel |first1=RS |last2=Pross |first2=HF |last3=Leibovitz |first3=A |title=Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors. |journal=International journal of cancer |date=1977-11-15 |volume=20 |issue=5 |pages=673-9 |doi=10.1002/ijc.2910200505 |pmid=924690}}</ref> || [https://www.cellosaurus.org/CVCL_1115 CVCL_1115] {{Wayback|url=https://www.cellosaurus.org/CVCL_1115 |date=20240224115147 }}
|-
| [[HCC1428]] || 88.48h || Luminal || CRL-2327 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1252 CVCL_1252] {{Wayback|url=https://www.cellosaurus.org/CVCL_1252 |date=20240207073917 }}
|-
| [[HCC1500]] || 46.85h || ? || CRL-2329 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1254 CVCL_1254] {{Wayback|url=https://www.cellosaurus.org/CVCL_1254 |date=20240207073926 }}
|-
| [[MDA-MB-134-VI]] || 82.67h || Luminal || HTB-23 || <ref name=MDA-MB/> || [https://www.cellosaurus.org/CVCL_0617 CVCL_0617] {{Wayback|url=https://www.cellosaurus.org/CVCL_0617 |date=20240424061155 }}
|-
| [[MDA-MB-175-VII]] || 112.26h || Luminal || HTB-25 || <ref name=MDA-MB/> || [https://www.cellosaurus.org/CVCL_1400 CVCL_1400] {{Wayback|url=https://www.cellosaurus.org/CVCL_1400 |date=20221004205911 }}
|-
| [[MDA-MB-415]] || 88.87h || Luminal || HTB-128 || <ref name=MDA-MB/> || [https://www.cellosaurus.org/CVCL_0621 CVCL_0621] {{Wayback|url=https://www.cellosaurus.org/CVCL_0621 |date=20240222090100 }}
|-
| [[ZR-75-1細胞|ZR-75-1]] || 70.09h || Luminal || CRL-1504 || <ref name="#1">{{cite journal |last1=Dorssers |first1=LC |last2=van Agthoven |first2=T |title=Genetic mechanisms of estrogen-independence in breast cancer. |journal=Pathology, research and practice |date=1996-07 |volume=192 |issue=7 |pages=743-51 |doi=10.1016/S0344-0338(96)80096-3 |pmid=8880875 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/8880875/ |accessdate=2019-11-28}}</ref> || [https://www.cellosaurus.org/CVCL_0588 CVCL_0588] {{Wayback|url=https://www.cellosaurus.org/CVCL_0588 |date=20240203181342 }}
|-
|-
|}
|}

===HER2amp===
===HER2amp===
{| class="wikitable sortable"
{| class="wikitable sortable"
! 细胞系 !! 文献 !! 外部链接
! 细胞系 !! 倍增时间 !! 转录亚型 !! ATCC ID !! 文献 !! 外部链接
|-
|-
| [[SK-BR-3]] || <ref name=MSKCC>{{cite web|title=SK-BR-3: Human Breast Cancer Cell Line (ATCC HTB-30)|url=https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-breast-cell-line-sk-br-3|publisher=Memorial Sloan-Kettering Cancer Center|access-date=2018-06-18|archive-url=https://web.archive.org/web/20180618230514/https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-breast-cell-line-sk-br-3|archive-date=2018-06-18|dead-url=no}}</ref> || [https://www.cellosaurus.org/CVCL_0033 CVCL_0033]
| [[SK-BR-3]] || 56.19h || HER2+ || HTB-30 || <ref name=MSKCC>{{cite web|title=SK-BR-3: Human Breast Cancer Cell Line (ATCC HTB-30)|url=https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-breast-cell-line-sk-br-3|publisher=Memorial Sloan-Kettering Cancer Center|access-date=2018-06-18|archive-url=https://web.archive.org/web/20180618230514/https://www.mskcc.org/research-advantage/support/technology/tangible-material/human-breast-cell-line-sk-br-3|archive-date=2018-06-18|dead-url=no}}</ref> || [https://www.cellosaurus.org/CVCL_0033 CVCL_0033] {{Wayback|url=https://www.cellosaurus.org/CVCL_0033 |date=20240424095439 }}
|-
|-
| [[AU565]] || <ref name=AU-565>{{cite journal |last1=Bacus |first1=SS |last2=Kiguchi |first2=K |last3=Chin |first3=D |last4=King |first4=CR |last5=Huberman |first5=E |title=Differentiation of cultured human breast cancer cells (AU-565 and MCF-7) associated with loss of cell surface HER-2/neu antigen. |journal=Molecular carcinogenesis |date=1990 |volume=3 |issue=6 |pages=350-62 |doi=10.1002/mc.2940030607 |pmid=1980588 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/1980588/ |accessdate=2019-12-04}}</ref> || [https://www.cellosaurus.org/CVCL_1074 CVCL_1074]
| [[AU565]] || 46.31h || HER2+ || CRL-2351 || <ref name=AU-565>{{cite journal |last1=Bacus |first1=SS |last2=Kiguchi |first2=K |last3=Chin |first3=D |last4=King |first4=CR |last5=Huberman |first5=E |title=Differentiation of cultured human breast cancer cells (AU-565 and MCF-7) associated with loss of cell surface HER-2/neu antigen. |journal=Molecular carcinogenesis |date=1990 |volume=3 |issue=6 |pages=350-62 |doi=10.1002/mc.2940030607 |pmid=1980588 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/1980588/ |accessdate=2019-12-04}}</ref> || [https://www.cellosaurus.org/CVCL_1074 CVCL_1074] {{Wayback|url=https://www.cellosaurus.org/CVCL_1074 |date=20191204092901 }}
|-
|-
| [[BT-474]] || <ref>{{cite journal |last1=Lasfargues |first1=EY |last2=Coutinho |first2=WG |last3=Dion |first3=AS |title=A human breast tumor cell line (BT-474) that supports mouse mammary tumor virus replication. |journal=In vitro |date=1979-09 |volume=15 |issue=9 |pages=723-9 |doi=10.1007/bf02618252 |pmid=94035 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/94035/ |accessdate=2019-12-07}}</ref> || [https://www.cellosaurus.org/CVCL_0179 CVCL_0179]
| [[BT-474]] || 92.49h || HER2+ || HTB-20 || <ref>{{cite journal |last1=Lasfargues |first1=EY |last2=Coutinho |first2=WG |last3=Dion |first3=AS |title=A human breast tumor cell line (BT-474) that supports mouse mammary tumor virus replication. |journal=In vitro |date=1979-09 |volume=15 |issue=9 |pages=723-9 |doi=10.1007/bf02618252 |pmid=94035 |url=https://www.ncbi.nlm.nih.gov/m/pubmed/94035/ |accessdate=2019-12-07}}</ref> || [https://www.cellosaurus.org/CVCL_0179 CVCL_0179] {{Wayback|url=https://www.cellosaurus.org/CVCL_0179 |date=20230930071653 }}
|-
| [[HCC202]] || 212.49h || HER2+ || CRL-2316 || <ref name=HCC>{{cite journal |last1=Gazdar |first1=AF |last2=Kurvari |first2=V |last3=Virmani |first3=A |last4=Gollahon |first4=L |last5=Sakaguchi |first5=M |last6=Westerfield |first6=M |last7=Kodagoda |first7=D |last8=Stasny |first8=V |last9=Cunningham |first9=HT |last10=Wistuba |first10=II |last11=Tomlinson |first11=G |last12=Tonk |first12=V |last13=Ashfaq |first13=R |last14=Leitch |first14=AM |last15=Minna |first15=JD |last16=Shay |first16=JW |title=Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer. |journal=International journal of cancer |date=1998-12-09 |volume=78 |issue=6 |pages=766-74 |doi=10.1002/(sici)1097-0215(19981209)78:6<766::aid-ijc15>3.0.co;2-l |pmid=9833771}}</ref> || [https://www.cellosaurus.org/CVCL_2062 CVCL_2062] {{Wayback|url=https://www.cellosaurus.org/CVCL_2062 |date=20240222071328 }}
|-
| [[HCC1419]] || 161.42h || HER2+ || CRL-2326 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1251 CVCL_1251] {{Wayback|url=https://www.cellosaurus.org/CVCL_1251 |date=20240207131032 }}
|-
| [[HCC1569]] || 45.43h || ? || CRL-2330 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1255 CVCL_1255] {{Wayback|url=https://www.cellosaurus.org/CVCL_1255 |date=20240207073922 }}
|-
| [[HCC1954]] || 43.81h || HER2+ || CRL-2338 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1259 CVCL_1259] {{Wayback|url=https://www.cellosaurus.org/CVCL_1259 |date=20240207131034 }}
|-
| [[HCC2218]] || 120h || HER2+ || CRL-2343 || <ref name=HCC/> || [https://www.cellosaurus.org/CVCL_1263 CVCL_1263] {{Wayback|url=https://www.cellosaurus.org/CVCL_1263 |date=20240207073925 }}
|-
| [[MDA-MB-361]] || 92.83h || HER2+ || HTB-27 || <ref name=MDA-MB/> || [https://www.cellosaurus.org/CVCL_0620 CVCL_0620] {{Wayback|url=https://www.cellosaurus.org/CVCL_0620 |date=20240207131037 }}
|-
| [[UACC-812]] || 104.68h || HER2+ || CRL-1897 || <ref name=UACC>{{cite journal |last1=Meltzer |first1=P |last2=Leibovitz |first2=A |last3=Dalton |first3=W |last4=Villar |first4=H |last5=Kute |first5=T |last6=Davis |first6=J |last7=Nagle |first7=R |last8=Trent |first8=J |title=Establishment of two new cell lines derived from human breast carcinomas with HER-2/neu amplification. |url=https://archive.org/details/sim_british-journal-of-cancer_1991-05_63_5/page/727 |journal=British journal of cancer |date=1991-05 |volume=63 |issue=5 |pages=727-35 |doi=10.1038/bjc.1991.164 |pmid=1674877}}</ref> || [https://www.cellosaurus.org/CVCL_1782 CVCL_1782] {{Wayback|url=https://www.cellosaurus.org/CVCL_1782 |date=20220922194424 }}
|-
| [[UACC-893]] || 248.53h || Luminal || CRL-1902 || <ref name=UACC/> || [https://www.cellosaurus.org/CVCL_1781 CVCL_1781] {{Wayback|url=https://www.cellosaurus.org/CVCL_1781 |date=20221005225401 }}
|-
| [[ZR-75-30]] || 324.46h || Luminal || CRL-1504 || <ref>{{cite journal |last1=Engel |first1=LW |last2=Young |first2=NA |last3=Tralka |first3=TS |last4=Lippman |first4=ME |last5=O'Brien |first5=SJ |last6=Joyce |first6=MJ |title=Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. |url=https://archive.org/details/sim_cancer-research_1978-10_38_10/page/3352 |journal=Cancer research |date=1978-10 |volume=38 |issue=10 |pages=3352-64 |pmid=688225}}</ref> || [https://www.cellosaurus.org/CVCL_1661 CVCL_1661] {{Wayback|url=https://www.cellosaurus.org/CVCL_1661 |date=20240416045507 }}
|-
|-
|}
|}

===NM===
===NM===
{| class="wikitable sortable"
{| class="wikitable sortable"
! 细胞系 !! 文献 !! 外部链接
! 细胞系 !! 倍增时间 !! 转录亚型 !! ATCC ID !! 文献 !! 外部链接
|-
|-
| [[MCF-10A]] || <ref name="MCF-10">{{cite journal |last1=Soule |first1=HD |last2=Maloney |first2=TM |last3=Wolman |first3=SR |last4=Peterson WD |first4=Jr |last5=Brenz |first5=R |last6=McGrath |first6=CM |last7=Russo |first7=J |last8=Pauley |first8=RJ |last9=Jones |first9=RF |last10=Brooks |first10=SC |title=Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. |journal=Cancer research |date=1990-09-15 |volume=50 |issue=18 |pages=6075-86 |pmid=1975513}}</ref> || [https://www.cellosaurus.org/CVCL_0598 CVCL_0598]
| [[MCF-10A]] || 26.74h || Non-malignant Basal || CRL-10317 || <ref name="MCF-10">{{cite journal |last1=Soule |first1=HD |last2=Maloney |first2=TM |last3=Wolman |first3=SR |last4=Peterson WD |first4=Jr |last5=Brenz |first5=R |last6=McGrath |first6=CM |last7=Russo |first7=J |last8=Pauley |first8=RJ |last9=Jones |first9=RF |last10=Brooks |first10=SC |title=Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. |journal=Cancer research |date=1990-09-15 |volume=50 |issue=18 |pages=6075-86 |pmid=1975513}}</ref> || [https://www.cellosaurus.org/CVCL_0598 CVCL_0598] {{Wayback|url=https://www.cellosaurus.org/CVCL_0598 |date=20240221083906 }}
|-
|-
| [[MCF-10F]] || <ref name="MCF-10"/> || [https://www.cellosaurus.org/CVCL_3633 CVCL_3633]
| [[MCF-10F]] || 47.44h || Non-malignant Basal || CRL-10318 || <ref name="MCF-10"/> || [https://www.cellosaurus.org/CVCL_3633 CVCL_3633] {{Wayback|url=https://www.cellosaurus.org/CVCL_3633 |date=20240428161402 }}
|-
|-
| [[MCF-12A]] || 35.42h || Non-malignant Basal || CRL-10782 || <ref>{{cite journal |last1=Neve |first1=RM |last2=Chin |first2=K |last3=Fridlyand |first3=J |last4=Yeh |first4=J |last5=Baehner |first5=FL |last6=Fevr |first6=T |last7=Clark |first7=L |last8=Bayani |first8=N |last9=Coppe |first9=JP |last10=Tong |first10=F |last11=Speed |first11=T |last12=Spellman |first12=PT |last13=DeVries |first13=S |last14=Lapuk |first14=A |last15=Wang |first15=NJ |last16=Kuo |first16=WL |last17=Stilwell |first17=JL |last18=Pinkel |first18=D |last19=Albertson |first19=DG |last20=Waldman |first20=FM |last21=McCormick |first21=F |last22=Dickson |first22=RB |last23=Johnson |first23=MD |last24=Lippman |first24=M |last25=Ethier |first25=S |last26=Gazdar |first26=A |last27=Gray |first27=JW |title=A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. |journal=Cancer cell |date=2006-12 |volume=10 |issue=6 |pages=515-27 |doi=10.1016/j.ccr.2006.10.008 |pmid=17157791}}</ref> || [https://www.cellosaurus.org/CVCL_3744 CVCL_3744] {{Wayback|url=https://www.cellosaurus.org/CVCL_3744 |date=20240225023759 }}
| [[MCF-12A]] || || [https://www.cellosaurus.org/CVCL_0179 CVCL_0179]
|-
|-
|}
|}

2024年5月29日 (三) 21:27的最新版本

ICBP43是43种人类乳腺癌细胞系的列表[1],由美国国家癌症研究所的“癌症生物学综合计划”(Integrative Cancer Biology Program)列出[2],用于药物筛选等许多生物医学研究[3]

细胞系

[编辑]
细胞系 倍增时间 转录亚型 ATCC ID 文献 外部链接
BT-20 66.15h Basal HTB-19 [4] CVCL_0178页面存档备份,存于互联网档案馆
MDA-MB-231 41.9h Claudin-low HTB-26 [5] CVCL_0062页面存档备份,存于互联网档案馆
MDA-MB-468 62h Basal HTB-132 [6] CVCL_0419页面存档备份,存于互联网档案馆
Hs 578T 53.8h Claudin-low HTB-126 [7] CVCL_0332页面存档备份,存于互联网档案馆
BT-549 53.9h Claudin-low HTB-122 [8] CVCL_1092页面存档备份,存于互联网档案馆
184B5 56.15h Basal CRL-8799 [9] CVCL_4688页面存档备份,存于互联网档案馆
DU4475 90h HTB-123 [10] CVCL_1183页面存档备份,存于互联网档案馆
HCC38 50.98h Claudin-low CRL-2314 [11] CVCL_1267页面存档备份,存于互联网档案馆
HCC70 67.80h Basal CRL-2315 [11] CVCL_1270页面存档备份,存于互联网档案馆
HCC1187 69.35h Basal CRL-2322 [11] CVCL_1247页面存档备份,存于互联网档案馆
HCC1395 84.07h Claudin-low CRL-2324 [11] CVCL_1349页面存档备份,存于互联网档案馆
HCC1599 4-5d Basal CRL-2331 [11] CVCL_1256页面存档备份,存于互联网档案馆
HCC1806 36.66h Basal CRL-2335 [11] CVCL_1258页面存档备份,存于互联网档案馆
HCC1937 53.49h Basal CRL-2336 [11] CVCL_0290页面存档备份,存于互联网档案馆
HCC2157 CRL-2340 [11] CVCL_1261页面存档备份,存于互联网档案馆
MDA-MB-157 66.98h Claudin-low HTB-24 [6] CVCL_0618页面存档备份,存于互联网档案馆
MDA-MB-436 89.31h Claudin-low HTB-130 [6] CVCL_0623页面存档备份,存于互联网档案馆
MDA-MB-453 62.49h Luminal HTB-131 [12] CVCL_0418页面存档备份,存于互联网档案馆

HR+

[编辑]
细胞系 倍增时间 转录亚型 ATCC ID 文献 外部链接
MCF-7 25.4h Luminal HTB-22 [13] CVCL_0031页面存档备份,存于互联网档案馆
T-47D 45.5h Luminal HTB-133 [14] CVCL_0553页面存档备份,存于互联网档案馆
BT-483 140.00h Luminal HTB-121 [15] CVCL_2319页面存档备份,存于互联网档案馆
CAMA-1 72.94h Luminal HTB-21 [16] CVCL_1115页面存档备份,存于互联网档案馆
HCC1428 88.48h Luminal CRL-2327 [11] CVCL_1252页面存档备份,存于互联网档案馆
HCC1500 46.85h CRL-2329 [11] CVCL_1254页面存档备份,存于互联网档案馆
MDA-MB-134-VI 82.67h Luminal HTB-23 [6] CVCL_0617页面存档备份,存于互联网档案馆
MDA-MB-175-VII 112.26h Luminal HTB-25 [6] CVCL_1400页面存档备份,存于互联网档案馆
MDA-MB-415 88.87h Luminal HTB-128 [6] CVCL_0621页面存档备份,存于互联网档案馆
ZR-75-1 70.09h Luminal CRL-1504 [17] CVCL_0588页面存档备份,存于互联网档案馆

HER2amp

[编辑]
细胞系 倍增时间 转录亚型 ATCC ID 文献 外部链接
SK-BR-3 56.19h HER2+ HTB-30 [18] CVCL_0033页面存档备份,存于互联网档案馆
AU565 46.31h HER2+ CRL-2351 [19] CVCL_1074页面存档备份,存于互联网档案馆
BT-474 92.49h HER2+ HTB-20 [20] CVCL_0179页面存档备份,存于互联网档案馆
HCC202 212.49h HER2+ CRL-2316 [11] CVCL_2062页面存档备份,存于互联网档案馆
HCC1419 161.42h HER2+ CRL-2326 [11] CVCL_1251页面存档备份,存于互联网档案馆
HCC1569 45.43h CRL-2330 [11] CVCL_1255页面存档备份,存于互联网档案馆
HCC1954 43.81h HER2+ CRL-2338 [11] CVCL_1259页面存档备份,存于互联网档案馆
HCC2218 120h HER2+ CRL-2343 [11] CVCL_1263页面存档备份,存于互联网档案馆
MDA-MB-361 92.83h HER2+ HTB-27 [6] CVCL_0620页面存档备份,存于互联网档案馆
UACC-812 104.68h HER2+ CRL-1897 [21] CVCL_1782页面存档备份,存于互联网档案馆
UACC-893 248.53h Luminal CRL-1902 [21] CVCL_1781页面存档备份,存于互联网档案馆
ZR-75-30 324.46h Luminal CRL-1504 [22] CVCL_1661页面存档备份,存于互联网档案馆

NM

[编辑]
细胞系 倍增时间 转录亚型 ATCC ID 文献 外部链接
MCF-10A 26.74h Non-malignant Basal CRL-10317 [23] CVCL_0598页面存档备份,存于互联网档案馆
MCF-10F 47.44h Non-malignant Basal CRL-10318 [23] CVCL_3633页面存档备份,存于互联网档案馆
MCF-12A 35.42h Non-malignant Basal CRL-10782 [24] CVCL_3744页面存档备份,存于互联网档案馆

另见

[编辑]

参考文献

[编辑]
  1. ^ ICBP43 cell lines - HMS LINCS Project. lincs.hms.harvard.edu. [2024-02-03]. (原始内容存档于2024-01-31). 
  2. ^ Reagents - HMS LINCS Project. lincs.hms.harvard.edu. [2024-02-03]. (原始内容存档于2024-01-31). 
  3. ^ Anderson, Alexander R. A.; Tomlin, Claire J.; Couch, Jennifer; Gallahan, Dan. Mathematics of the Integrative Cancer Biology Program. Interface Focus. 2013-08-06, 3 (4): 20130023. doi:10.1098/RSFS.2013.0023. 
  4. ^ Chavez, KJ; Garimella, SV; Lipkowitz, S. Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer.. Breast disease. 2010, 32 (1-2): 35–48 [2019-12-04]. PMID 21778573. doi:10.3233/BD-2010-0307. 
  5. ^ Cailleau, R; Young, R; Olivé, M; Reeves WJ, Jr. Breast tumor cell lines from pleural effusions.. Journal of the National Cancer Institute. 1974-09, 53 (3): 661–74. PMID 4412247. doi:10.1093/jnci/53.3.661. 
  6. ^ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Cailleau, R; Olivé, M; Cruciger, QV. Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization.. In vitro. 1978-11, 14 (11): 911–5 [2020-02-14]. PMID 730202. doi:10.1007/bf02616120. (原始内容存档于2020-02-14). 
  7. ^ Hackett, AJ; Smith, HS; Springer, EL; Owens, RB; Nelson-Rees, WA; Riggs, JL; Gardner, MB. Two syngeneic cell lines from human breast tissue: the aneuploid mammary epithelial (Hs578T) and the diploid myoepithelial (Hs578Bst) cell lines.. Journal of the National Cancer Institute. 1977-06, 58 (6): 1795–806. PMID 864756. doi:10.1093/jnci/58.6.1795. 
  8. ^ Lasfargues, EY; Coutinho, WG; Redfield, ES. Isolation of two human tumor epithelial cell lines from solid breast carcinomas.. Journal of the National Cancer Institute. 1978-10, 61 (4): 967–78 [2019-12-07]. PMID 212572. (原始内容存档于2013-12-17). 
  9. ^ Stampfer, MR; Bartley, JC. Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.. Proceedings of the National Academy of Sciences of the United States of America. 1985-04, 82 (8): 2394–8. PMID 3857588. doi:10.1073/pnas.82.8.2394. 
  10. ^ Langlois, AJ; Holder WD, Jr; Iglehart, JD; Nelson-Rees, WA; Wells SA, Jr; Bolognesi, DP. Morphological and biochemical properties of a new human breast cancer cell line.. Cancer research. 1979-07, 39 (7 Pt 1): 2604–13. PMID 221108. 
  11. ^ 11.00 11.01 11.02 11.03 11.04 11.05 11.06 11.07 11.08 11.09 11.10 11.11 11.12 11.13 11.14 Gazdar, AF; Kurvari, V; Virmani, A; Gollahon, L; Sakaguchi, M; Westerfield, M; Kodagoda, D; Stasny, V; Cunningham, HT; Wistuba, II; Tomlinson, G; Tonk, V; Ashfaq, R; Leitch, AM; Minna, JD; Shay, JW. Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer.. International journal of cancer. 1998-12-09, 78 (6): 766–74. PMID 9833771. doi:10.1002/(sici)1097-0215(19981209)78:6<766::aid-ijc15>3.0.co;2-l. 
  12. ^ Hall, RE; Birrell, SN; Tilley, WD; Sutherland, RL. MDA-MB-453, an androgen-responsive human breast carcinoma cell line with high level androgen receptor expression.. European journal of cancer (Oxford, England : 1990). 1994, 30A (4): 484–90 [2020-02-14]. PMID 8018407. doi:10.1016/0959-8049(94)90424-3. [永久失效連結]
  13. ^ Lee, Adrian V.; et al. MCF-7 Cells—Changing the Course of Breast Cancer Research and Care for 45 Years. Journal of the National Cancer Institute. 1 July 2015, 107 (7): djv073. PMID 25828948. doi:10.1093/jnci/djv073. 
  14. ^ Yu, S; Kim, T; Yoo, KH; Kang, K. The T47D cell line is an ideal experimental model to elucidate the progesterone-specific effects of a luminal A subtype of breast cancer.. Biochemical and biophysical research communications. 2017-05-06, 486 (3): 752–758 [2019-11-30]. PMID 28342866. doi:10.1016/j.bbrc.2017.03.114. 
  15. ^ Lasfargues, EY; Coutinho, WG; Redfield, ES. Isolation of two human tumor epithelial cell lines from solid breast carcinomas.. Journal of the National Cancer Institute. 1978-10, 61 (4): 967–78 [2019-12-07]. PMID 212572. (原始内容存档于2013-12-17). 
  16. ^ Kerbel, RS; Pross, HF; Leibovitz, A. Analysis of established human carcinoma cell lines for lymphoreticular-associated membrane receptors.. International journal of cancer. 1977-11-15, 20 (5): 673–9. PMID 924690. doi:10.1002/ijc.2910200505. 
  17. ^ Dorssers, LC; van Agthoven, T. Genetic mechanisms of estrogen-independence in breast cancer.. Pathology, research and practice. 1996-07, 192 (7): 743–51 [2019-11-28]. PMID 8880875. doi:10.1016/S0344-0338(96)80096-3. 
  18. ^ SK-BR-3: Human Breast Cancer Cell Line (ATCC HTB-30). Memorial Sloan-Kettering Cancer Center. [2018-06-18]. (原始内容存档于2018-06-18). 
  19. ^ Bacus, SS; Kiguchi, K; Chin, D; King, CR; Huberman, E. Differentiation of cultured human breast cancer cells (AU-565 and MCF-7) associated with loss of cell surface HER-2/neu antigen.. Molecular carcinogenesis. 1990, 3 (6): 350–62 [2019-12-04]. PMID 1980588. doi:10.1002/mc.2940030607. 
  20. ^ Lasfargues, EY; Coutinho, WG; Dion, AS. A human breast tumor cell line (BT-474) that supports mouse mammary tumor virus replication.. In vitro. 1979-09, 15 (9): 723–9 [2019-12-07]. PMID 94035. doi:10.1007/bf02618252. 
  21. ^ 21.0 21.1 Meltzer, P; Leibovitz, A; Dalton, W; Villar, H; Kute, T; Davis, J; Nagle, R; Trent, J. Establishment of two new cell lines derived from human breast carcinomas with HER-2/neu amplification.. British journal of cancer. 1991-05, 63 (5): 727–35. PMID 1674877. doi:10.1038/bjc.1991.164. 
  22. ^ Engel, LW; Young, NA; Tralka, TS; Lippman, ME; O'Brien, SJ; Joyce, MJ. Establishment and characterization of three new continuous cell lines derived from human breast carcinomas.. Cancer research. 1978-10, 38 (10): 3352–64. PMID 688225. 
  23. ^ 23.0 23.1 Soule, HD; Maloney, TM; Wolman, SR; Peterson WD, Jr; Brenz, R; McGrath, CM; Russo, J; Pauley, RJ; Jones, RF; Brooks, SC. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10.. Cancer research. 1990-09-15, 50 (18): 6075–86. PMID 1975513. 
  24. ^ Neve, RM; Chin, K; Fridlyand, J; Yeh, J; Baehner, FL; Fevr, T; Clark, L; Bayani, N; Coppe, JP; Tong, F; Speed, T; Spellman, PT; DeVries, S; Lapuk, A; Wang, NJ; Kuo, WL; Stilwell, JL; Pinkel, D; Albertson, DG; Waldman, FM; McCormick, F; Dickson, RB; Johnson, MD; Lippman, M; Ethier, S; Gazdar, A; Gray, JW. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.. Cancer cell. 2006-12, 10 (6): 515–27. PMID 17157791. doi:10.1016/j.ccr.2006.10.008.