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硫酸魚精蛋白：修订间差异

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{{Expand language|1=en|time=2024-12-17T14:40:47+00:00}}
{{Infobox drug
{{Infobox drug
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| drug_name =
| type = <!-- empty -->
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⚫
| IUPAC_name =
⚫
<!-- Names -->
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| image =
| image =
| alt =
| alt =
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<!-- Clinical data -->
⚫
| caption =
| pronounce =
| pronounce =
| tradename = Prosulf, others
| tradename = Prosulf, others
| Drugs.com = {{Drugs.com|monograph|protamine-sulfate}}
| Drugs.com = {{Drugs.com|monograph|protamine-sulfate}}
| MedlinePlus = <!-- Legal data -->
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| pregnancy_AU = <!-- A/B1/B2/B3/C/D/X -->
| pregnancy_AU = <!-- A/B1/B2/B3/C/D/X -->
| pregnancy_AU_comment=
| pregnancy_AU_comment =
| pregnancy_US = C
| pregnancy_category=
| pregnancy_category=
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
⚫
| routes_of_administration = [[靜脈注射]]
⚫
| legal_AU_comment=
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
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| routes_of_administration= IV
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| onset = 5 分鐘<ref name=UK2016/>
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}}
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⚫
'''硫酸魚精蛋白'''是一种可逆转[[肝素]]作用的[[靜脈注射|静脉注射]]药物<ref name="AHFS2016">{{Cite web|title=Protamine Sulfate|url=https://www.drugs.com/monograph/protamine-sulfate.html|publisher=The American Society of Health-System Pharmacists|access-date=8 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161106063702/https://www.drugs.com/monograph/protamine-sulfate.html|archive-date=6 November 2016}} {{Webarchive|url=https://web.archive.org/web/20161106063702/https://www.drugs.com/monograph/protamine-sulfate.html|date=6 November 2016}}</ref>。专门用于治疗[[肝素|肝素过量]]、{{tsl|en|Low-molecular-weight heparin|低分子量肝素}}过量以及逆转[[分娩]]和[[心血管外科|心脏手术]]过程中肝素的作用<ref name="AHFS2016" /> <ref name="Recombinant2019">{{Cite web|title=Protamine sulfate|url=https://www.drugbank.ca/drugs/DB09141|website=www.drugbank.ca|access-date=14 February 2019|archive-date=2 May 2019|archive-url=https://web.archive.org/web/20190502074328/https://www.drugbank.ca/drugs/DB09141|url-status=live}} {{Webarchive|url=https://web.archive.org/web/20190502074328/https://www.drugbank.ca/drugs/DB09141|date=2 May 2019}}</ref>。药效通常在五分钟内出现<ref name="UK2016">{{Cite web|title=Prosulf 10mg/ml Solution for Injection - Summary of Product Characteristics (SPC) - (eMC)|url=https://www.medicines.org.uk/emc/medicine/13567|website=www.medicines.org.uk|access-date=14 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161220184414/https://www.medicines.org.uk/emc/medicine/13567|archive-date=20 December 2016}} {{Webarchive|url=https://web.archive.org/web/20161220184414/https://www.medicines.org.uk/emc/medicine/13567|date=20 December 2016}}</ref>。


⚫
'''硫酸魚精蛋白'''是一种可逆转[[肝素]]作用的[[靜脈注射]]药物<ref name="AHFS2016">{{Cite web|title=Protamine Sulfate|url=https://www.drugs.com/monograph/protamine-sulfate.html|publisher=The American Society of Health-System Pharmacists|access-date=8 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161106063702/https://www.drugs.com/monograph/protamine-sulfate.html|archive-date=6 November 2016}} {{Webarchive|url=https://web.archive.org/web/20161106063702/https://www.drugs.com/monograph/protamine-sulfate.html|date=6 November 2016}}</ref>。专门用于治疗[[肝素]]或{{tsl|en|Low-molecular-weight heparin|低分子量肝素}}过量以及逆转[[分娩]]和[[心血管外科|心脏手术]]过程中肝素的作用<ref name="AHFS2016" /> <ref name="Recombinant2019">{{Cite web|title=Protamine sulfate|url=https://www.drugbank.ca/drugs/DB09141|website=www.drugbank.ca|access-date=14 February 2019|archive-date=2 May 2019|archive-url=https://web.archive.org/web/20190502074328/https://www.drugbank.ca/drugs/DB09141|url-status=live}} {{Webarchive|url=https://web.archive.org/web/20190502074328/https://www.drugbank.ca/drugs/DB09141|date=2 May 2019}}</ref>。药效通常在五分钟内出现<ref name="UK2016">{{Cite web|title=Prosulf 10mg/ml Solution for Injection - Summary of Product Characteristics (SPC) - (eMC)|url=https://www.medicines.org.uk/emc/medicine/13567|website=www.medicines.org.uk|access-date=14 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161220184414/https://www.medicines.org.uk/emc/medicine/13567|archive-date=20 December 2016}} {{Webarchive|url=https://web.archive.org/web/20161220184414/https://www.medicines.org.uk/emc/medicine/13567|date=20 December 2016}}</ref>。
常见副作用包括[[低血壓|低血压]]、[[心跳过缓|心率减慢]]、[[过敏|过敏反应]]和呕吐<ref name="AHFS2016" />。过敏反应可能很严重，包括[[严重过敏反应|过敏性休克]]<ref name="AHFS2016" />。已进行[[输精管切除术]]的男性發生副作用的风险較高<ref name="WHO2008">{{Cite book|title=WHO Model Formulary 2008|year=2009|isbn=9789241547659|vauthors=((World Health Organization))|author-link=World Health Organization|publisher=World Health Organization|page=255}}</ref>。虽然無明確证据顯示孕期使用有害，但針對孕婦的相關研究仍不足<ref>{{Cite web|title=Protamine Use During Pregnancy {{!}} Drugs.com|url=https://www.drugs.com/pregnancy/protamine.html|website=www.drugs.com|access-date=14 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161221010812/https://www.drugs.com/pregnancy/protamine.html|archive-date=21 December 2016}} {{Webarchive|url=https://web.archive.org/web/20161221010812/https://www.drugs.com/pregnancy/protamine.html|date=21 December 2016}}</ref>。魚精蛋白与[[肝素]]结合，而逆轉肝素的作用<ref name="AHFS2016" />。


硫酸魚精蛋白于1969 年在美国取得医疗使用許可<ref name="AHFS2016" />。名列[[世界卫生组织基本药物标准清单|世界卫生组织基本药物清单]]<ref name="WHO21st">{{Cite book|vauthors=((World Health Organization))|title=World Health Organization model list of essential medicines: 21st list 2019|year=2019|author-link=World Health Organization|publisher=World Health Organization|location=Geneva|id=WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO}}</ref>。最初是由[[鮭魚|鲑鱼]]精子制成<ref name="AHFS2016" />。目前，主要由[[重組DNA|重组DNA技术]]生产<ref name="Kern2012">{{Cite book|author=Kern|first=Morton J.|title=The Interventional Cardiac Catheterization Handbook E-Book|date=2012|publisher=Elsevier Health Sciences|isbn=9781455740420|page=131|url=https://books.google.ca/books?id=E27-2_qutX0C&pg=PA131|language=en|accessdate=2019-02-14|archivedate=2019-02-15|archiveurl=https://web.archive.org/web/20190215050536/https://books.google.ca/books?id=E27-2_qutX0C&pg=PA131}} {{Webarchive|url=https://web.archive.org/web/20221014001342/https://books.google.ca/books?id=E27-2_qutX0C&pg=PA131|date=2022-10-14}}</ref>。
常见副作用包括[[低血壓]]、[[心跳过缓]]、[[过敏]]和呕吐<ref name="AHFS2016" />。过敏反应可能很严重，包括[[严重过敏反应|过敏性休克]]<ref name="AHFS2016" />。已进行[[输精管切除术]]的男性發生副作用的风险較高<ref name="WHO2008">{{Cite book|title=WHO Model Formulary 2008|year=2009|isbn=9789241547659|vauthors=((World Health Organization))|author-link=World Health Organization|publisher=World Health Organization|page=255}}</ref>。虽然無明確证据顯示孕期使用有害，但針對孕婦的相關研究仍不足<ref>{{Cite web|title=Protamine Use During Pregnancy {{!}} Drugs.com|url=https://www.drugs.com/pregnancy/protamine.html|website=www.drugs.com|access-date=14 December 2016|url-status=live|archive-url=https://web.archive.org/web/20161221010812/https://www.drugs.com/pregnancy/protamine.html|archive-date=21 December 2016}} {{Webarchive|url=https://web.archive.org/web/20161221010812/https://www.drugs.com/pregnancy/protamine.html|date=21 December 2016}}</ref>。魚精蛋白与[[肝素]]结合，而逆轉肝素的作用<ref name="AHFS2016" />。

硫酸魚精蛋白于1969 年在美国取得医疗使用許可<ref name="AHFS2016" />。名列[[世界卫生组织基本药物标准清单]]<ref name="WHO21st">{{Cite book|vauthors=((World Health Organization))|title=World Health Organization model list of essential medicines: 21st list 2019|year=2019|author-link=World Health Organization|publisher=World Health Organization|location=Geneva|id=WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO}}</ref>。最初是由[[鮭魚|鲑鱼]]精子制成<ref name="AHFS2016" />。目前，主要利用[[重組DNA]]技术生产<ref name="Kern2012">{{Cite book|author=Kern|first=Morton J.|title=The Interventional Cardiac Catheterization Handbook E-Book|date=2012|publisher=Elsevier Health Sciences|isbn=9781455740420|page=131|url=https://books.google.ca/books?id=E27-2_qutX0C&pg=PA131|language=en|accessdate=2019-02-14|archivedate=2019-02-15|archiveurl=https://web.archive.org/web/20190215050536/https://books.google.ca/books?id=E27-2_qutX0C&pg=PA131}} {{Webarchive|url=https://web.archive.org/web/20221014001342/https://books.google.ca/books?id=E27-2_qutX0C&pg=PA131|date=2022-10-14}}</ref>。


== 参考文獻 ==
== 参考文獻 ==
{{reflist}}
<references />

[[Category:Translated from MDWiki]]
== 外部連結 ==
* {{MeshName|Protamine+Sulfate}}
* {{cite web | url = https://druginfo.nlm.nih.gov/drugportal/name/protamine%20sulfate | publisher = 美國國家醫學圖書館 | work = 藥物資訊網 | title = 硫酸魚精蛋白}}

{{抗出血藥}}
{{解毒劑}}

{{portal bar|Medicine}}

[[Category:解毒剂]]
[[Category:世界卫生组织基本药物]]

2024年12月17日 (二) 14:40的最新版本

硫酸魚精蛋白
臨床資料
商品名（英语：Drug nomenclature）Prosulf, others
AHFS/Drugs.comMonograph
给药途径靜脈注射
藥物動力學數據
藥效起始時間（英语：Onset of action）5 分鐘[1]
识别信息
CAS号9009-65-8
DrugBank
UNII
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
ECHA InfoCard100.113.361 編輯維基數據鏈接


硫酸魚精蛋白是一种可逆转肝素作用的靜脈注射药物[2]。专门用于治疗肝素或低分子量肝素过量以及逆转分娩和心脏手术过程中肝素的作用[2] [3]。药效通常在五分钟内出现[1]。

常见副作用包括低血壓、心跳过缓、过敏和呕吐[2]。过敏反应可能很严重，包括过敏性休克[2]。已进行输精管切除术的男性發生副作用的风险較高[4]。虽然無明確证据顯示孕期使用有害，但針對孕婦的相關研究仍不足[5]。魚精蛋白与肝素结合，而逆轉肝素的作用[2]。

硫酸魚精蛋白于1969 年在美国取得医疗使用許可[2]。名列世界卫生组织基本药物标准清单[6]。最初是由鲑鱼精子制成[2]。目前，主要利用重組DNA技术生产[7]。

参考文獻

[编辑]
  1. ^ 1.0 1.1 Prosulf 10mg/ml Solution for Injection - Summary of Product Characteristics (SPC) - (eMC). www.medicines.org.uk. [14 December 2016]. （原始内容存档于20 December 2016）.  互联网档案馆的存檔，存档日期20 December 2016.
  2. ^ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Protamine Sulfate. The American Society of Health-System Pharmacists. [8 December 2016]. （原始内容存档于6 November 2016）.  互联网档案馆的存檔，存档日期6 November 2016.
  3. ^ Protamine sulfate. www.drugbank.ca. [14 February 2019]. （原始内容存档于2 May 2019）.  互联网档案馆的存檔，存档日期2 May 2019.
  4. ^ World Health Organization. WHO Model Formulary 2008. World Health Organization. 2009: 255. ISBN 9789241547659. 
  5. ^ Protamine Use During Pregnancy | Drugs.com. www.drugs.com. [14 December 2016]. （原始内容存档于21 December 2016）.  互联网档案馆的存檔，存档日期21 December 2016.
  6. ^ World Health Organization. World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. 
  7. ^ Kern, Morton J. The Interventional Cardiac Catheterization Handbook E-Book. Elsevier Health Sciences. 2012: 131 [2019-02-14]. ISBN 9781455740420. （原始内容存档于2019-02-15） （英语）.  互联网档案馆的存檔，存档日期2022-10-14.

外部連結

[编辑]
检索自“https://zh.wikipedia.org/zhwiki/w/index.php?title=硫酸魚精蛋白&oldid=85343024”