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曲唑酮：修订间差异

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| bioavailability = [[口服给药]]: 65%<ref name="DrugPoint">Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013. {{Failed verification|date=April 2017|reason=search for "Trazodone" fails on Truven Web site}}</ref>
| bioavailability = [[口服给药]]: 65%<ref name="DrugPoint">Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013. {{Failed verification|date=April 2017|reason=search for "Trazodone" fails on Truven Web site}}</ref>
| protein_bound = 89–95%<ref>{{cite web|url=http://www.drugbank.ca/drugs/DB00656| title=Trazodone|website=DrugBank|accessdate=7 June 2015}}</ref>
| protein_bound = 89–95%<ref>{{cite web|url=http://www.drugbank.ca/drugs/DB00656| title=Trazodone|website=DrugBank|accessdate=7 June 2015}}</ref>
| metabolism = [[肝臟|Liver]] ([[CYP3A4]])<ref>{{cite book |last1=Lemke |first1=Thomas L. |last2=Williams |first2=David A. |title=Foye's Principles of Medicinal Chemistry |date=2012 |publisher=Lippincott Williams & Wilkins |isbn=9781609133450 |page=615 |url=https://books.google.ca/books?id=Sd6ot9ul-bUC&pg=PA615 |language=en}}</ref>
| metabolism = [[肝臟]]（[[CYP3A4]]）<ref>{{cite book |last1=Lemke |first1=Thomas L. |last2=Williams |first2=David A. |title=Foye's Principles of Medicinal Chemistry |date=2012 |publisher=Lippincott Williams & Wilkins |isbn=9781609133450 |page=615 |url=https://books.google.ca/books?id=Sd6ot9ul-bUC&pg=PA615 |language=en}}</ref>
| metabolites = {{abbrlink|mCPP|meta-Chlorophenylpiperazine}}<ref name="PreskornStanga2012">{{cite book|author1=Sheldon H. Preskorn|author2=Christina Y. Stanga|author3=John P. Feighner|author4=Ruth Ross|title=Antidepressants: Past, Present and Future|url=https://books.google.com/books?id=Ue3uCAAAQBAJ&pg=PA68|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-3-642-18500-7|pages=68–}}</ref>
| metabolites = {{abbrlink|mCPP|meta-Chlorophenylpiperazine}}<ref name="PreskornStanga2012">{{cite book|author1=Sheldon H. Preskorn|author2=Christina Y. Stanga|author3=John P. Feighner|author4=Ruth Ross|title=Antidepressants: Past, Present and Future|url=https://books.google.com/books?id=Ue3uCAAAQBAJ&pg=PA68|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-3-642-18500-7|pages=68–}}</ref>
| onset = [[口服给药|By mouth]]: 1 hour ({{tsl|en|Tmax (pharmacology)||{{abbr|T<sub>max</sub>|Time to peak concentrations}}}})<ref>{{cite web |url=http://www.pharmacychoice.com/mdx/drugpoint.cfm?docID=622860&letter=T&type=Generic%20Name |title=MicroMedex DrugPoints - Trazodone|website=Pharmacy Choice|date= |author= |accessdate= 20 April 2017}}</ref>
| onset = [[口服给药|By mouth]]: 1 hour ({{tsl|en|Tmax (pharmacology)||{{abbr|T<sub>max</sub>|Time to peak concentrations}}}})<ref>{{cite web |url=http://www.pharmacychoice.com/mdx/drugpoint.cfm?docID=622860&letter=T&type=Generic%20Name |title=MicroMedex DrugPoints - Trazodone|website=Pharmacy Choice|date= |author= |accessdate= 20 April 2017}}</ref>
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{{镇痛药}}
{{镇痛药}}
{{Hypnotics_and_sedatives}}
{{Hypnotics_and_sedatives}}
{{藥學小作品}}
[[Category:血清素受体激动剂]]
[[Category:血清素受体激动剂]]
[[Category:血清素拮抗剂]]
[[Category:血清素拮抗剂]]

2019年2月25日 (一) 15:20的版本

曲唑酮
臨床資料
商品名（英语：Drug nomenclature）Many brand names worldwide[1]
其他名稱AF-1161
AHFS/Drugs.comMonograph
MedlinePlusa681038
给药途径By mouth (tablets)
ATC碼
法律規範狀態
法律規範
藥物動力學數據
生物利用度口服给药: 65%[2]
血漿蛋白結合率89–95%[3]
药物代谢肝臟（CYP3A4）[7]
代謝產物mCPP[4]
藥效起始時間（英语：Onset of action）By mouth: 1 hour (Tmax（英语：Tmax (pharmacology)）)[5]
生物半衰期Trazodone IR: 7 hours[2]
Trazodone ER: 10 hours[2]
mCPP: 4–8 hours[6]
排泄途徑尿：70–75%[2]
糞便：21%[2]
识别信息
  • 2-{3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
CAS号19794-93-5  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)
ECHA InfoCard100.039.364 編輯維基數據鏈接
化学信息
化学式C19H22ClN5O
摩尔质量371.8641 g/mol
3D模型（JSmol（英语：JSmol））
  • Clc4cccc(N3CCN(CCCN1/N=C2/C=C\C=C/N2C1=O)CC3)c4
  • InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2 checkY
  • Key:PHLBKPHSAVXXEF-UHFFFAOYSA-N checkY
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曲唑酮（英語：Trazodone）是一種口服抗抑鬱藥.[8]，用來治療重性抑鬱障礙、焦慮症，也配合其他藥品來治療酒精依賴[8]。Trazodone以多種商品名行銷於世界各地[1]。

常見的副作用包含口乾、頭昏、嘔吐和頭痛[8]，較為嚴重的副作用為：自殺、躁狂導致之雙極性精神症狀、心律不整、陰莖異常勃起[8]。目前還不清楚在懷孕或哺乳期間使用是否安全[9]。該藥物品屬於苯基哌嗪（phenylpiperazine）類藥物，為一種血清素拮抗劑和再攝取抑制劑（英语：Serotonin antagonist and reuptake inhibitor）（SARI）[10][11]，Trazodone還具有鎮靜的副作用[12]。

該藥品於1981年在美國批准用於醫療用途[8]，現已有通用名藥物上市[8]。截至2019年，每月劑量在英國公醫（NHS）的採購藥價約7.46英鎊[13]。2018年，美國的每月劑量批發價約4.53美元[14]。2016年，它是美國第24大處方用藥，單年處方超過2500萬筆 [15]。


是一種抗抑郁药，用來治療重性抑郁障碍、焦虑症、酒精依賴或其他療程的輔助藥品。Trazodone以多種商品名行銷於世界各地。[1][8]

Trazodone常見的副作用包含口乾、頭暈、呕吐和頭痛。較為嚴重的副作用為：自殺、躁鬱症、心律不整、陰莖異常勃起。[8]

文獻來源

  1. ^ 1.0 1.1 1.2 Drugs.com international listings for Trazodone Page accessed Feb 10, 2016
  2. ^ 2.0 2.1 2.2 2.3 2.4 Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013. [與來源不符]
  3. ^ Trazodone. DrugBank. [7 June 2015]. 
  4. ^ Sheldon H. Preskorn; Christina Y. Stanga; John P. Feighner; Ruth Ross. Antidepressants: Past, Present and Future. Springer Science & Business Media. 6 December 2012: 68–. ISBN 978-3-642-18500-7. 
  5. ^ MicroMedex DrugPoints - Trazodone. Pharmacy Choice. [20 April 2017]. 
  6. ^ Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. 2017: 460–. ISBN 978-1-58562-523-9. 
  7. ^ Lemke, Thomas L.; Williams, David A. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 2012: 615. ISBN 9781609133450 （英语）. 
  8. ^ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Trazodone Hydrochloride. The American Society of Health-System Pharmacists. [8 January 2018]. 
  9. ^ Trazodone Use During Pregnancy. Drugs.com. [7 January 2018]. 
  10. ^ Stahl, Stephen M. Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. Cambridge University Press. 2008: 567. ISBN 9780521857024 （英语）. 
  11. ^ Lemke, Thomas L.; Williams, David A. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 2008: 586. ISBN 9780781768795 （英语）. 
  12. ^ British national formulary : BNF 69 69. British Medical Association. 2015: 257–258. ISBN 9780857111562. 
  13. ^ British national formulary : BNF 76 76. Pharmaceutical Press. 2018: 367. ISBN 9780857113382. 
  14. ^ NADAC as of 2018-01-03. Centers for Medicare and Medicaid Services. [7 January 2018] （英语）. 
  15. ^ The Top 300 of 2019. clincalc.com. [22 December 2018]. 
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