曲唑酮
外观
臨床資料 | |
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商品名 | Many brand names worldwide[1] |
其他名稱 | AF-1161 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a681038 |
给药途径 | By mouth (tablets) |
ATC碼 | |
法律規範狀態 | |
法律規範 |
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藥物動力學數據 | |
生物利用度 | By mouth: 65%[2] |
血漿蛋白結合率 | 89–95%[3] |
药物代谢 | Liver (CYP3A4)[7] |
代謝產物 | mCPP[4] |
藥效起始時間 | By mouth: 1 hour (Tmax)[5] |
生物半衰期 | Trazodone IR: 7 hours[2] Trazodone ER: 10 hours[2] mCPP: 4–8 hours[6] |
排泄途徑 | Urine: 70–75%[2] Feces: 21%[2] |
识别信息 | |
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CAS号 | 19794-93-5 |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.039.364 |
化学信息 | |
化学式 | C19H22ClN5O |
摩尔质量 | 371.8641 g/mol |
3D模型(JSmol) | |
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曲唑酮(英語:Trazodone)是一種抗抑郁药,用來治療重性抑郁障碍、焦虑症、酒精依賴或其他療程的輔助藥品。Trazodone以多種商品名行銷於世界各地。[1][8]
Trazodone常見的副作用包含口乾、頭暈、呕吐和頭痛。較為嚴重的副作用為:自殺、躁鬱症、心律不整、陰莖異常勃起。[8]
文獻來源
- ^ 1.0 1.1 Drugs.com international listings for Trazodone Page accessed Feb 10, 2016
- ^ 2.0 2.1 2.2 2.3 2.4 Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013. [與來源不符]
- ^ Trazodone. DrugBank. [7 June 2015].
- ^ Sheldon H. Preskorn; Christina Y. Stanga; John P. Feighner; Ruth Ross. Antidepressants: Past, Present and Future. Springer Science & Business Media. 6 December 2012: 68–. ISBN 978-3-642-18500-7.
- ^ MicroMedex DrugPoints - Trazodone. Pharmacy Choice. [20 April 2017].
- ^ Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. 2017: 460–. ISBN 978-1-58562-523-9.
- ^ Lemke, Thomas L.; Williams, David A. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 2012: 615. ISBN 9781609133450 (英语).
- ^ 8.0 8.1 Trazodone Hydrochloride. The American Society of Health-System Pharmacists. [8 January 2018].