曲唑酮

曲唑酮
臨床資料
商品名（英语：Drug nomenclature）	Many brand names worldwide
其他名稱	AF-1161
AHFS/Drugs.com	Monograph
MedlinePlus	a681038
给药途径	By mouth (tablets)
ATC碼	N06AX05 (WHO) ;
法律規範狀態
法律規範	澳：限医生处方（S4）; 加：处方药（℞-only）; 英：处方药（℞-only） (POM); 美：处方药（℞-only）;
藥物動力學數據
生物利用度	口服给药: 65%
血漿蛋白結合率	89–95%
药物代谢	Liver (CYP3A4)
代謝產物	mCPP
藥效起始時間（英语：Onset of action）	By mouth: 1 hour (Tmax（英语：Tmax (pharmacology)）)
生物半衰期	Trazodone IR: 7 hours; Trazodone ER: 10 hours; mCPP: 4–8 hours
排泄途徑	尿：70–75%; 糞便：21%
识别信息
	IUPAC命名法 2-{3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one; ;
CAS号	19794-93-5
PubChem CID	5533;
IUPHAR/BPS	213;
DrugBank	DB00656 ;
ChemSpider	5332 ;
UNII	YBK48BXK30;
KEGG	D08626 ;
ChEBI	CHEBI:9654 ;
ChEMBL	ChEMBL621 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID5045043 ;
ECHA InfoCard	100.039.364
化学信息
化学式	C19H22ClN5O
摩尔质量	371.8641 g/mol
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES Clc4cccc(N3CCN(CCCN1/N=C2/C=C\C=C/N2C1=O)CC3)c4;
	InChI InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2 ; Key:PHLBKPHSAVXXEF-UHFFFAOYSA-N ;

曲唑酮（英語：Trazodone）是一種口服抗抑鬱藥.^[8]，用來治療重性抑鬱障礙、焦慮症，也配合其他藥品來治療酒精依賴^[8]。Trazodone以多種商品名行銷於世界各地^[1]。

常見的副作用包含口乾、頭昏、嘔吐和頭痛^[8]，較為嚴重的副作用為：自殺、躁狂導致之雙極性精神症狀、心律不整、陰莖異常勃起^[8]。目前還不清楚在懷孕或哺乳期間使用是否安全^[9]。該藥物品屬於苯基哌嗪（phenylpiperazine）類藥物，為一種血清素拮抗劑和再攝取抑制劑（英语：Serotonin antagonist and reuptake inhibitor）（SARI）^[10]^[11]，Trazodone還具有鎮靜的副作用^[12]。

該藥品於1981年在美國批准用於醫療用途^[8]，現已有通用名藥物上市^[8]。截至2019年，每月劑量在英國公醫（NHS）的採購藥價約7.46英鎊^[13]。2018年，美國的每月劑量批發價約4.53美元^[14]。2016年，它是美國第24大處方用藥，單年處方超過2500萬筆 ^[15]。

是一種抗抑郁药，用來治療重性抑郁障碍、焦虑症、酒精依賴或其他療程的輔助藥品。Trazodone以多種商品名行銷於世界各地。^[1]^[8]

Trazodone常見的副作用包含口乾、頭暈、呕吐和頭痛。較為嚴重的副作用為：自殺、躁鬱症、心律不整、陰莖異常勃起。^[8]

文獻來源

^ ^1.0 ^1.1 ^1.2 Drugs.com international listings for Trazodone Page accessed Feb 10, 2016
^ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013. ^{[與來源不符]}
^ Trazodone. DrugBank. [7 June 2015].
^ Sheldon H. Preskorn; Christina Y. Stanga; John P. Feighner; Ruth Ross. Antidepressants: Past, Present and Future. Springer Science & Business Media. 6 December 2012: 68–. ISBN 978-3-642-18500-7.
^ MicroMedex DrugPoints - Trazodone. Pharmacy Choice. [20 April 2017].
^ Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. 2017: 460–. ISBN 978-1-58562-523-9.
^ Lemke, Thomas L.; Williams, David A. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 2012: 615. ISBN 9781609133450 （英语）.
^ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Trazodone Hydrochloride. The American Society of Health-System Pharmacists. [8 January 2018].
^ Trazodone Use During Pregnancy. Drugs.com. [7 January 2018].
^ Stahl, Stephen M. Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. Cambridge University Press. 2008: 567. ISBN 9780521857024 （英语）.
^ Lemke, Thomas L.; Williams, David A. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 2008: 586. ISBN 9780781768795 （英语）.
^ British national formulary : BNF 69 69. British Medical Association. 2015: 257–258. ISBN 9780857111562.
^ British national formulary : BNF 76 76. Pharmaceutical Press. 2018: 367. ISBN 9780857113382.
^ NADAC as of 2018-01-03. Centers for Medicare and Medicaid Services. [7 January 2018] （英语）.
^ The Top 300 of 2019. clincalc.com. [22 December 2018].

这是一篇與药学相關的小作品。您可以通过编辑或修订扩充其内容。

[genericnames-1] 1.0 ^1.1 ^1.2 Drugs.com international listings for Trazodone Page accessed Feb 10, 2016

[DrugPoint-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Oct 1]. Greenwood Village, CO: Thomsen Healthcare; 2013. ^{[與來源不符]}

[3] Trazodone. DrugBank. [7 June 2015].

[PreskornStanga2012-4] Sheldon H. Preskorn; Christina Y. Stanga; John P. Feighner; Ruth Ross. Antidepressants: Past, Present and Future. Springer Science & Business Media. 6 December 2012: 68–. ISBN 978-3-642-18500-7.

[5] MicroMedex DrugPoints - Trazodone. Pharmacy Choice. [20 April 2017].

[SchatzbergNemeroff2017-6] Alan F. Schatzberg, M.D.; Charles B. Nemeroff, M.D., Ph.D. The American Psychiatric Association Publishing Textbook of Psychopharmacology, Fifth Edition. American Psychiatric Pub. 2017: 460–. ISBN 978-1-58562-523-9.

[7] Lemke, Thomas L.; Williams, David A. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 2012: 615. ISBN 9781609133450 （英语）.

[AHFS2018-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Trazodone Hydrochloride. The American Society of Health-System Pharmacists. [8 January 2018].

[9] Trazodone Use During Pregnancy. Drugs.com. [7 January 2018].

[10] Stahl, Stephen M. Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. Cambridge University Press. 2008: 567. ISBN 9780521857024 （英语）.

[11] Lemke, Thomas L.; Williams, David A. Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 2008: 586. ISBN 9780781768795 （英语）.

[BNF69-12] British national formulary : BNF 69 69. British Medical Association. 2015: 257–258. ISBN 9780857111562.

[BNF76-13] British national formulary : BNF 76 76. Pharmaceutical Press. 2018: 367. ISBN 9780857113382.

[14] NADAC as of 2018-01-03. Centers for Medicare and Medicaid Services. [7 January 2018] （英语）.

[15] The Top 300 of 2019. clincalc.com. [22 December 2018].

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