粒细胞-巨噬细胞集落刺激因子

现有可用的蛋白结构：
Pfam	结构（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	结构概要

粒细胞-巨噬细胞集落刺激因子
粒细胞-巨噬细胞集落刺激因子
	重组人粒细胞巨噬细胞集落刺激因子（rhGM_CSF）的三维结构
鉴定
标志	GM_CSF
Pfam	PF01109（旧版）
Pfam宗系	CL0053（旧版）
InterPro（英语：InterPro）	IPR000773
PROSITE（英语：PROSITE）	PDOC00584
SCOP（英语：Structural Classification of Proteins）	2gmf / SUPFAM
Pfam
现有可用的蛋白结构：
Pfam	结构（旧版） / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum（英语：PDBsum）	结构概要

粒细胞-巨噬细胞集落刺激因子
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1CSG、2GMF、4NKQ、5C7X、5D70、5D71、5D72、4RS1
识别号
别名	CSF2；, GMCSF, colony stimulating factor 2, CSF
外部ID	OMIM：138960 MGI：1339752 HomoloGene：600 GeneCards：CSF2
基因位置（人类）
染色体	5号染色体
终止	132,076,170 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	54,140,493 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• 生长因子活性; • granulocyte macrophage colony-stimulating factor receptor binding; • 血浆蛋白结合; • protein tyrosine kinase activity; • 细胞因子活性;
细胞组分	• 细胞外区域; • 细胞内膜结合细胞器; • 细胞外空间;
生物学过程	• negative regulation of cytolysis; • positive regulation of macrophage derived foam cell differentiation; • regulation of cell population proliferation; • MAPK cascade; • positive regulation of podosome assembly; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • positive regulation of interleukin-23 production; • positive regulation of gene expression; • embryonic placenta development; • epithelial fluid transport; • 基因调节; • dendritic cell differentiation; • myeloid dendritic cell differentiation; • macrophage activation; • cellular response to lipopolysaccharide; • 免疫反应; • monocyte differentiation; • response to fluid shear stress; • response to silicon dioxide; • neutrophil differentiation; • peptidyl-tyrosine phosphorylation; • regulation of circadian sleep/wake cycle, sleep; • histamine secretion; • positive regulation of tyrosine phosphorylation of STAT protein; • cellular response to granulocyte macrophage colony-stimulating factor stimulus; • regulation of myeloid cell differentiation; • regulation of signaling receptor activity; • negative regulation of transcription, DNA-templated; • cytokine-mediated signaling pathway; • positive regulation of cell population proliferation; • macrophage differentiation;
	Sources:Amigo / QuickGO
直系同源
	1437
	12981
	ENSG00000164400
	ENSMUSG00000018916
	P04141
	P01587
	NM_000758
	NM_009969
	NP_000749
	NP_034099
	维基数据
查看/编辑人类	查看/编辑小鼠

粒细胞-巨噬细胞集落刺激因子
临床数据

ATC码	L03AA09 (WHO)
识别信息
IUPAC命名法 Human granulocyte macrophage colony stimulating factor
CAS号	83869-56-1 ^Y
DrugBank	DB00020^N
ChemSpider	无^N
化学信息
化学式	C₆₃₉H₁₀₀₆N₁₆₈O₁₉₆S₈
摩尔质量	14434.5 g/mol

粒细胞-巨噬细胞集落刺激因子（granulocyte-macrophage colony-stimulating factor，GM-CSF），又名集落刺激因子2（colony-stimulating factor 2，CSF2），是由巨噬细胞、T细胞、肥大细胞、自然杀伤细胞、内皮细胞和成纤维细胞分泌的一种单体糖蛋白细胞因子。沙格司亭（英语：sargramostim）和莫拉司亭是天然存在的GM-CSF的药品类似物。

与促进中性粒细胞增殖和成熟的粒细胞集落刺激因子（英语：granulocyte colony-stimulating factor）不同，粒细胞-巨噬细胞集落刺激因子影响的细胞种类更多，尤其是巨噬细胞和嗜酸性粒细胞^[5]。

参考资料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000164400 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000018916 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Root RK, Dale DC. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: comparisons and potential for use in the treatment of infections in nonneutropenic patients. The Journal of Infectious Diseases. March 1999,. 179 Suppl 2 (Suppl 2): S342–52. PMID 10081506. doi:10.1086/513857.

外部链接

医学主题词表（MeSH）：Granulocyte-Macrophage+Colony-Stimulating+Factor

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000164400 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000018916 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10081506-5] Root RK, Dale DC. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: comparisons and potential for use in the treatment of infections in nonneutropenic patients. The Journal of Infectious Diseases. March 1999,. 179 Suppl 2 (Suppl 2): S342–52. PMID 10081506. doi:10.1086/513857.

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