CXCL1

Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
	PDB rendering based on 1mgs.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1MGS, 1MSG, 1MSH, 1ROD
标识
代号	CXCL1; FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1
扩展标识	遗传学：155730 鼠基因：3037818 同源基因：117693 GeneCards: CXCL1 Gene
基因本体论描述
分子功能	· receptor binding; · chemokine activity; · enzyme activator activity; · growth factor activity;
细胞成分	· extracellular region; · extracellular space;
生物过程	· chemotaxis; · inflammatory response; · immune response; · signal transduction; · G-protein coupled receptor signaling pathway; · nervous system development; · cell proliferation; · negative regulation of cell proliferation; · actin cytoskeleton organization; · intracellular signal transduction; · positive regulation of catalytic activity;
	Sources: Amigo / QuickGO
直系同源体
物种	人类
Entrez	2919
Ensembl	ENSG00000163739
UniProt	P09341
mRNA序列	NM_001511
蛋白序列	NP_001502
基因位置	Chr 4:; 74.74 – 74.74 Mb
PubMed查询	[1]
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CXCL1（英语：Chemokine (C-X-C motif) ligand 1）是一小分子的细胞因子属于CXC趋化因子家族^[1]。又被称作生长调节致癌基因α (Growth-regulated oncogene alpha, GROα)^[1]^[2]^[3]。趋化因子CXCL1是由巨噬细胞，中性粒细胞和上皮细胞表达的^[4]^[5]。趋化因子CXCL1对中性粒细胞有细胞趋化作用^[1]。CXCL1结合到趋化因子受体CXCR2上而起细胞趋化作用^[6]。人类的CXCL1与许多CXC类的趋化因子基因相邻聚集在第四染色体上^[7] 。CXCL1的主要作用包括新血管形成、炎症反应、伤口愈合^[6]和肿瘤形成^[2]^[3]。

参见

参考文献

^ ^1.0 ^1.1 ^1.2 Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M. Neutrophil-activating properties of the melanoma growth-stimulatory activity. J Exp Med. 1990 May 1;171(5):1797-802.
^ ^2.0 ^2.1 Anisowicz, A., Bardwell, L., Sager, R. Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc. Nat. Acad. Sci. 84: 7188-7192, 1987.
^ ^3.0 ^3.1 Richmond, A., Thomas, H. G. (1988) Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution J. Cell. Biochem. 36,185-198
^ Iida N, Grotendorst GR. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol Cell Biol. 1990 Oct;10(10):5596-9.
^ Becker S, Quay J, Koren HS, Haskill JS. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol. 1994 Mar;266(3 Pt 1):L278-86.
^ ^6.0 ^6.1 Devalaraja, R. M., Nanney, L. B., Du, J., Qian, Q., Yu, Y., Devalaraja, M. N., Richmond, A. (2000) Delayed wound healing in CXCR2 knockout mice J. Investig. Dermatol. 115,234-244
^ Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988 Jul;7(7):2025-33.

[mos-1] 1.0 ^1.1 ^1.2 Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M. Neutrophil-activating properties of the melanoma growth-stimulatory activity. J Exp Med. 1990 May 1;171(5):1797-802.

[#1-2] 2.0 ^2.1 Anisowicz, A., Bardwell, L., Sager, R. Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc. Nat. Acad. Sci. 84: 7188-7192, 1987.

[#2-3] 3.0 ^3.1 Richmond, A., Thomas, H. G. (1988) Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution J. Cell. Biochem. 36,185-198

[4] Iida N, Grotendorst GR. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol Cell Biol. 1990 Oct;10(10):5596-9.

[5] Becker S, Quay J, Koren HS, Haskill JS. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol. 1994 Mar;266(3 Pt 1):L278-86.

[#3-6] 6.0 ^6.1 Devalaraja, R. M., Nanney, L. B., Du, J., Qian, Q., Yu, Y., Devalaraja, M. N., Richmond, A. (2000) Delayed wound healing in CXCR2 knockout mice J. Investig. Dermatol. 115,234-244

[ric-7] Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988 Jul;7(7):2025-33.

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