Talk:Mutation/Archive 2
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Exome
A new paper (PMID 20518025) (ahead of print) [http://www.physorg.com/news195385687.html (lay summary) indicates that because "Protein coding genes constitute approximately 1% of the human genome but harbor 85% of the mutations with large effects on disease-related traits" it is a useful strategy to focus on the exome when looking for SNPs that cause rare diseases. The paper asserts that with only two unrelated donors with a genetic disease it was possible to find the SNP they share which causes it. In their example they found mutations causing Fowler's syndrome affecting FLVCR2, but authors anticipate that the search strategy will greatly accelerate the search for such SNPs. LeadSongDog come howl! 18:45, 10 June 2010 (UTC)
Two templates
Template:Evolution3 and Template:Genetics2 are both on the page of this article. The evolution template has been there for longer but I recently added the genetics template. It feels crowded, but yet imperative to the article, as mutation goes hand in hand with evolution and genetics? Should we keep them both on or just one? I know the creation–evolution controversy page has two templates, and seems of course slightly crowded, but is this article deserving or two? Thoughts? Andrew Colvin • Talk 04:31, 3 July 2010 (UTC)
- Having two templates seems excessive. In my opinion, such templates (even when only one is present) are generally less helpful to uninformed readers than lead images that introduce the subject. In this article, for instance, a simple image depicting an example of a mutation would be helpful in visually introducing readers to what a mutation is. Ideally, such a lead image would be more obvious than the picture of the benzo[a]pyrene adduct and less complicated than the diagram of chromosomal translocations. Emw (talk) 05:50, 3 July 2010 (UTC)
Somatic Mutations
Heya people, I noticed that the page Somatic mutation links back here but Germline mutation has its own page. Do you think that perhaps somatic mutations should have their own page too? I'll happily build it but I thought I'd check here before doing it in case this has come up before. Cheers, Abergabe (talk) 10:46, 1 September 2010 (UTC)