User:Ghesketh

Membrane Traffic Underlying Cellular Function

I have recently received my PhD in Biological Chemistry from The Johns Hopkins University in Baltimore, Maryland. I am now post-doctoral researcher at the Cambridge Institute for Medical Research at the University of Cambridge in the UK.

During my PhD I studied trafficking mechanisms of the gap junction protein Connexin43 in the heart. I was able to demonstrate that cardiac gap junctions may be formed between cardiomyocyte lateral membranes and are extensively internalized and degraded via autophagy. Additionally, I identified and functionally characterized phosphorylation sites within Cx43 that are involved in gap junction traffic.

My current research relates to the biogenesis and function of lysosomes and lysosome related organelles.