User:Kgrodzki/Messenger RNP

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Messenger RNP

Messenger RNPs were first discovered in Alexander S. Spirin's laboratory in Moscow, Russia in 1964. The discovery was based in their study of fish embryo cytoplasm extracts, where they found these mRNPs. This finding was discovered after the mRNA of the fish embryo was centrifuged. The mRNA liquid separated into two parts, having the scientists question what is separate of the mrNA from the ribosomes. Spirin and his collaborators analyzed the mRNA against CsCl density gradients and discovered that parts of the mRNA were coated in proteins. The weight ratio of mRNPs was found to be 1:3, mRNA to protein. mRNPs were thus denoted as informosomes by the lab. ^[1]

There are three major informosomes found in mammalian cells: nuclear ribonucleoproteins, cytoplasmic informosomes, and polyribosomal messenger ribonucleoproteins. It was hypothesized by researchers that major roles of informosomes are to assist in mRNAs translocation from the nucleus to the cytoplasm, protect the mRNA against degradation, and help regulate protein formation. ^[2] Copied from Messenger RNP:Neurodegenerative diseases in RNP granules are caused by genetic mutations. RNP granules store specific types of mRNAs under tight translational control while forming different types. Just edited some of the grammar.

References

^ Spirin, Alexander (March 1979). "Messenger ribonucleoproteins (informosomes) and RNA-binding proteins". Molecular Biology Reports – Springer Journals. 5: 5 – via Springer Link.
^ L. P. Ovchinnikov, T. N. Vlasik, S. P. Domogatsky, T. A. Seryakova, A. S. Spirin (1979). "Eukaryotic Translation Factors and RNA-Binding Proteins". Macromolecules in the Functioning Cell: 111–129 – via Springer Link.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[1] Spirin, Alexander (March 1979). "Messenger ribonucleoproteins (informosomes) and RNA-binding proteins". Molecular Biology Reports – Springer Journals. 5: 5 – via Springer Link.

[2] L. P. Ovchinnikov, T. N. Vlasik, S. P. Domogatsky, T. A. Seryakova, A. S. Spirin (1979). "Eukaryotic Translation Factors and RNA-Binding Proteins". Macromolecules in the Functioning Cell: 111–129 – via Springer Link.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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