User:NorwegianBlue/Somatic recombination
Somatic recombination, as opposed to the genetic recombination that occurs in meiosis, is an alteration of the DNA of a somatic cell that is inherited by its daughter cells. The term is usually reserved for large-scale alterations of DNA such as deletions and translocations, and not applied to point mutations. Somatic recombination occurs physiologically in the assembly of the B cell receptor and T-cell receptor (V(D)J recombination)[1], as well as in the class switching of immunoglobulins[2]. Somatic recombination is also important in the process of carcinogenesis[3].
References
[edit]- ^ Gellert M (1992) Molecular analysis of V(D)J recombination. Annu Rev Genet 26:425–46. PMID 1482120
- ^ Hein K, Lorenz MG, Siebenkotten G, et al. (1998) Processing of switch transcripts is required for targeting of antibody class switch recombination. J Exp Med 188:2369–74. PMID 9858523
- ^ Ramel C, Cederberg H, Magnusson J, et al. (1996) Somatic recombination, gene amplification and cancer. Mutat Res 353:85–107. PMID 8692194
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