Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 23:33, 7 November 2007 (UTC)
[edit]Proteins without matches (18)
[edit]Proteins with a High Potential Match (7)
[edit]Manual Inspection (Page not found) (17)
[edit]
Protein Status Grid - Date: 23:33, 7 November 2007 (UTC)
[edit]Vebose Log - Date: 23:33, 7 November 2007 (UTC)
[edit]- INFO: Beginning work on ABCD1... {November 7, 2007 3:05:28 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:05:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ATP-binding cassette, sub-family D (ALD), member 1
| HGNCid = 61
| Symbol = ABCD1
| AltSymbols =; ABC42; ALD; ALDP; AMN
| OMIM = 300371
| ECnumber =
| Homologene = 55426
| MGIid = 1349215
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042626 |text = ATPase activity, coupled to transmembrane movement of substances}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005777 |text = peroxisome}} {{GNF_GO|id=GO:0005779 |text = integral to peroxisomal membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007031 |text = peroxisome organization and biogenesis}} {{GNF_GO|id=GO:0015919 |text = peroxisomal membrane transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 215
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000024
| Hs_RefseqmRNA = NM_000033
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 11666
| Mm_Ensembl = ENSMUSG00000031378
| Mm_RefseqmRNA = XM_973209
| Mm_RefseqProtein = XP_978303
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 69969429
| Mm_GenLoc_end = 69991252
| Mm_Uniprot = P48410
}}
}}
'''ATP-binding cassette, sub-family D (ALD), member 1''', also known as '''ABCD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.<ref>{{cite web | title = Entrez Gene: ABCD1 ATP-binding cassette, sub-family D (ALD), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=215| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Aubourg P, Mosser J, Douar AM, ''et al.'' |title=Adrenoleukodystrophy gene: unexpected homology to a protein involved in peroxisome biogenesis. |journal=Biochimie |volume=75 |issue= 3-4 |pages= 293-302 |year= 1993 |pmid= 8507690 |doi= }}
*{{cite journal | author=Moser HW, Powers JM, Smith KD |title=Adrenoleukodystrophy: molecular genetics, pathology, and Lorenzo's oil. |journal=Brain Pathol. |volume=5 |issue= 3 |pages= 259-66 |year= 1996 |pmid= 8520725 |doi= }}
*{{cite journal | author=Dodd A, Rowland SA, Hawkes SL, ''et al.'' |title=Mutations in the adrenoleukodystrophy gene. |journal=Hum. Mutat. |volume=9 |issue= 6 |pages= 500-11 |year= 1997 |pmid= 9195223 |doi= 10.1002/(SICI)1098-1004(1997)9:6<500::AID-HUMU2>3.0.CO;2-5 }}
*{{cite journal | author=Kemp S, Pujol A, Waterham HR, ''et al.'' |title=ABCD1 mutations and the X-linked adrenoleukodystrophy mutation database: role in diagnosis and clinical correlations. |journal=Hum. Mutat. |volume=18 |issue= 6 |pages= 499-515 |year= 2002 |pmid= 11748843 |doi= 10.1002/humu.1227 }}
*{{cite journal | author=Lan F |title=Molecular diagnostics in China. |journal=Clin. Chem. Lab. Med. |volume=39 |issue= 12 |pages= 1190-4 |year= 2002 |pmid= 11798073 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on BAG1... {November 7, 2007 3:05:48 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein BAG1 image.jpg {November 7, 2007 3:06:43 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:06:52 PM PST}
- CREATED: Created new protein page: BAG1 {November 7, 2007 3:06:59 PM PST}
- INFO: Beginning work on CDK6... {November 7, 2007 3:06:59 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CDK6 image.jpg {November 7, 2007 3:07:57 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:08:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CDK6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bi7.
| PDB = {{PDB2|1bi7}}, {{PDB2|1bi8}}, {{PDB2|1blx}}, {{PDB2|1g3n}}, {{PDB2|1jow}}, {{PDB2|1xo2}}, {{PDB2|2euf}}, {{PDB2|2f2c}}
| Name = Cyclin-dependent kinase 6
| HGNCid = 1777
| Symbol = CDK6
| AltSymbols =; MGC59692; PLSTIRE
| OMIM = 603368
| ECnumber =
| Homologene = 963
| MGIid = 1277162
| GeneAtlas_image1 = PBB_GE_CDK6_207143_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0000080 |text = G1 phase of mitotic cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1021
| Hs_Ensembl = ENSG00000105810
| Hs_RefseqProtein = NP_001250
| Hs_RefseqmRNA = NM_001259
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 92072175
| Hs_GenLoc_end = 92301148
| Hs_Uniprot = Q00534
| Mm_EntrezGene = 12571
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009873
| Mm_RefseqProtein = NP_034003
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Cyclin-dependent kinase 6''', also known as '''CDK6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.<ref>{{cite web | title = Entrez Gene: CDK6 cyclin-dependent kinase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1021| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CDKN2B... {November 7, 2007 3:08:10 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:08:53 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
| HGNCid = 1788
| Symbol = CDKN2B
| AltSymbols =; INK4B; MTS2; P15; TP15
| OMIM = 600431
| ECnumber =
| Homologene = 55859
| MGIid = 104737
| GeneAtlas_image1 = PBB_GE_CDKN2B_207530_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004861 |text = cyclin-dependent protein kinase inhibitor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1030
| Hs_Ensembl = ENSG00000147883
| Hs_RefseqProtein = NP_004927
| Hs_RefseqmRNA = NM_004936
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 21992902
| Hs_GenLoc_end = 21999312
| Hs_Uniprot = P42772
| Mm_EntrezGene = 12579
| Mm_Ensembl = ENSMUSG00000073802
| Mm_RefseqmRNA = XM_989888
| Mm_RefseqProtein = XP_994982
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 88777525
| Mm_GenLoc_end = 88782177
| Mm_Uniprot = O54846
}}
}}
'''Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)''', also known as '''CDKN2B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.<ref>{{cite web | title = Entrez Gene: CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1030| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CTSK... {November 7, 2007 3:08:53 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CTSK image.jpg {November 7, 2007 3:09:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:09:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CTSK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1atk.
| PDB = {{PDB2|1atk}}, {{PDB2|1au0}}, {{PDB2|1au2}}, {{PDB2|1au3}}, {{PDB2|1au4}}, {{PDB2|1ayu}}, {{PDB2|1ayv}}, {{PDB2|1ayw}}, {{PDB2|1bgo}}, {{PDB2|1by8}}, {{PDB2|1mem}}, {{PDB2|1nl6}}, {{PDB2|1nlj}}, {{PDB2|1q6k}}, {{PDB2|1snk}}, {{PDB2|1tu6}}, {{PDB2|1u9v}}, {{PDB2|1u9w}}, {{PDB2|1u9x}}, {{PDB2|1vsn}}, {{PDB2|1yk7}}, {{PDB2|1yk8}}, {{PDB2|1yt7}}, {{PDB2|2ato}}, {{PDB2|2aux}}, {{PDB2|2auz}}, {{PDB2|2bdl}}, {{PDB2|2f7d}}, {{PDB2|2ftd}}, {{PDB2|7pck}}
| Name = Cathepsin K
| HGNCid = 2536
| Symbol = CTSK
| AltSymbols =; CTS02; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD
| OMIM = 601105
| ECnumber =
| Homologene = 68053
| MGIid = 107823
| GeneAtlas_image1 = PBB_GE_CTSK_202450_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004216 |text = cathepsin K activity}}
| Component = {{GNF_GO|id=GO:0005764 |text = lysosome}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1513
| Hs_Ensembl = ENSG00000143387
| Hs_RefseqProtein = NP_000387
| Hs_RefseqmRNA = NM_000396
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 149035311
| Hs_GenLoc_end = 149047436
| Hs_Uniprot = P43235
| Mm_EntrezGene = 13038
| Mm_Ensembl = ENSMUSG00000028111
| Mm_RefseqmRNA = NM_007802
| Mm_RefseqProtein = NP_031828
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 95584660
| Mm_GenLoc_end = 95594766
| Mm_Uniprot = Q545T0
}}
}}
'''Cathepsin K''', also known as '''CTSK''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing.<ref>{{cite web | title = Entrez Gene: CTSK cathepsin K| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1513| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Motyckova G, Fisher DE |title=Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human disease. |journal=Curr. Mol. Med. |volume=2 |issue= 5 |pages= 407-21 |year= 2003 |pmid= 12125807 |doi= }}
*{{cite journal | author=Troen BR |title=The regulation of cathepsin K gene expression. |journal=Ann. N. Y. Acad. Sci. |volume=1068 |issue= |pages= 165-72 |year= 2006 |pmid= 16831915 |doi= 10.1196/annals.1346.018 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DRD1... {November 7, 2007 3:09:48 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:10:21 PM PST}
- CREATED: Created new protein page: DRD1 {November 7, 2007 3:10:29 PM PST}
- INFO: Beginning work on FANCC... {November 7, 2007 3:10:29 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:11:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Fanconi anemia, complementation group C
| HGNCid = 3584
| Symbol = FANCC
| AltSymbols =; FA3; FAC; FACC; FLJ14675
| OMIM = 227645
| ECnumber =
| Homologene = 109
| MGIid = 95480
| GeneAtlas_image1 = PBB_GE_FANCC_205189_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006289 |text = nucleotide-excision repair}} {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0007281 |text = germ cell development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2176
| Hs_Ensembl = ENSG00000158169
| Hs_RefseqProtein = NP_000127
| Hs_RefseqmRNA = NM_000136
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 96901158
| Hs_GenLoc_end = 97119812
| Hs_Uniprot = Q00597
| Mm_EntrezGene = 14088
| Mm_Ensembl = ENSMUSG00000021461
| Mm_RefseqmRNA = NM_001042673
| Mm_RefseqProtein = NP_001036138
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 63313931
| Mm_GenLoc_end = 63440720
| Mm_Uniprot = P50652
}}
}}
'''Fanconi anemia, complementation group C''', also known as '''FANCC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene delays the onset of apoptosis and promotes homologous recombination repair of damaged DNA. Mutations in this gene result in Fanconi anemia.<ref>{{cite web | title = Entrez Gene: FANCC Fanconi anemia, complementation group C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2176| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FOXO3A... {November 7, 2007 3:11:13 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:12:48 PM PST}
- CREATED: Created new protein page: FOXO3A {November 7, 2007 3:12:59 PM PST}
- INFO: Beginning work on GAA... {November 7, 2007 3:12:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:13:32 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II)
| HGNCid = 4065
| Symbol = GAA
| AltSymbols =; LYAG
| OMIM = 606800
| ECnumber =
| Homologene = 37268
| MGIid = 95609
| GeneAtlas_image1 = PBB_GE_GAA_202812_at_tn.png
| Function = {{GNF_GO|id=GO:0004553 |text = hydrolase activity, hydrolyzing O-glycosyl compounds}} {{GNF_GO|id=GO:0004558 |text = alpha-glucosidase activity}}
| Component = {{GNF_GO|id=GO:0005764 |text = lysosome}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0005980 |text = glycogen catabolic process}} {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2548
| Hs_Ensembl = ENSG00000171298
| Hs_RefseqProtein = NP_000143
| Hs_RefseqmRNA = NM_000152
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 75689877
| Hs_GenLoc_end = 75708273
| Hs_Uniprot = P10253
| Mm_EntrezGene = 14387
| Mm_Ensembl = ENSMUSG00000025579
| Mm_RefseqmRNA = NM_008064
| Mm_RefseqProtein = NP_032090
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 119084118
| Mm_GenLoc_end = 119101544
| Mm_Uniprot = P70699
}}
}}
'''Glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II)''', also known as '''GAA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes acid alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. Different forms of acid alpha-glucosidase are obtained by proteolytic processing. Defects in this gene are the cause of glycogen storage disease II, also known as Pompe's disease, which is an autosomal recessive disorder with a broad clinical spectrum. Three transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: GAA glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2548| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Reuser AJ, Kroos MA, Hermans MM, ''et al.'' |title=Glycogenosis type II (acid maltase deficiency). |journal=Muscle Nerve |volume=3 |issue= |pages= S61-9 |year= 1995 |pmid= 7603530 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HDAC4... {November 7, 2007 3:23:47 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HDAC4 image.jpg {November 7, 2007 3:24:25 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:24:43 PM PST}
- CREATED: Created new protein page: HDAC4 {November 7, 2007 3:24:50 PM PST}
- INFO: Beginning work on PKD2... {November 7, 2007 3:13:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:13:55 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Polycystic kidney disease 2 (autosomal dominant)
| HGNCid = 9009
| Symbol = PKD2
| AltSymbols =; PC2; APKD2; MGC138466; MGC138468; PKD4
| OMIM = 173910
| ECnumber =
| Homologene = 20104
| MGIid = 1099818
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005247 |text = voltage-gated chloride channel activity}} {{GNF_GO|id=GO:0005248 |text = voltage-gated sodium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0008092 |text = cytoskeletal protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005929 |text = cilium}} {{GNF_GO|id=GO:0005932 |text = basal body}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0007368 |text = determination of left/right symmetry}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0050974 |text = detection of mechanical stimulus during sensory perception}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5311
| Hs_Ensembl = ENSG00000118762
| Hs_RefseqProtein = NP_000288
| Hs_RefseqmRNA = NM_000297
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 89147844
| Hs_GenLoc_end = 89217952
| Hs_Uniprot = Q13563
| Mm_EntrezGene = 18764
| Mm_Ensembl = ENSMUSG00000034462
| Mm_RefseqmRNA = XM_984803
| Mm_RefseqProtein = XP_989897
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 104699752
| Mm_GenLoc_end = 104746120
| Mm_Uniprot = Q7TSI7
}}
}}
'''Polycystic kidney disease 2 (autosomal dominant)''', also known as '''PKD2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.<ref>{{cite web | title = Entrez Gene: PKD2 polycystic kidney disease 2 (autosomal dominant)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5311| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Torres VE |title=New insights into polycystic kidney disease and its treatment. |journal=Curr. Opin. Nephrol. Hypertens. |volume=7 |issue= 2 |pages= 159-69 |year= 1998 |pmid= 9529618 |doi= }}
*{{cite journal | author=Deltas CC |title=Mutations of the human polycystic kidney disease 2 (PKD2) gene. |journal=Hum. Mutat. |volume=18 |issue= 1 |pages= 13-24 |year= 2001 |pmid= 11438989 |doi= 10.1002/humu.1145 }}
*{{cite journal | author=Boletta A, Germino GG |title=Role of polycystins in renal tubulogenesis. |journal=Trends Cell Biol. |volume=13 |issue= 9 |pages= 484-92 |year= 2004 |pmid= 12946628 |doi= }}
*{{cite journal | author=Cantiello HF |title=Regulation of calcium signaling by polycystin-2. |journal=Am. J. Physiol. Renal Physiol. |volume=286 |issue= 6 |pages= F1012-29 |year= 2004 |pmid= 15130895 |doi= 10.1152/ajprenal.00181.2003 }}
*{{cite journal | author=Everson GT, Taylor MR, Doctor RB |title=Polycystic disease of the liver. |journal=Hepatology |volume=40 |issue= 4 |pages= 774-82 |year= 2004 |pmid= 15382167 |doi= 10.1002/hep.20431 }}
*{{cite journal | author=Witzgall R |title=TRPP2 channel regulation. |journal=Handb Exp Pharmacol |volume= |issue= 179 |pages= 363-75 |year= 2007 |pmid= 17217069 |doi= 10.1007/978-3-540-34891-7_22 }}
*{{cite journal | author=Köttgen M |title=TRPP2 and autosomal dominant polycystic kidney disease. |journal=Biochim. Biophys. Acta |volume=1772 |issue= 8 |pages= 836-50 |year= 2007 |pmid= 17292589 |doi= 10.1016/j.bbadis.2007.01.003 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRF1... {November 7, 2007 3:13:55 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:14:35 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Perforin 1 (pore forming protein)
| HGNCid = 9360
| Symbol = PRF1
| AltSymbols =; FLH2; HPLH2; MGC65093; P1; PFP
| OMIM = 170280
| ECnumber =
| Homologene = 3698
| MGIid = 97551
| GeneAtlas_image1 = PBB_GE_PRF1_214617_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016023 |text = cytoplasmic membrane-bound vesicle}}
| Process = {{GNF_GO|id=GO:0006926 |text = virus-infected cell apoptosis}} {{GNF_GO|id=GO:0006927 |text = transformed cell apoptosis}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0009405 |text = pathogenesis}} {{GNF_GO|id=GO:0019835 |text = cytolysis}} {{GNF_GO|id=GO:0019836 |text = hemolysis by symbiont of host red blood cells}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5551
| Hs_Ensembl = ENSG00000180644
| Hs_RefseqProtein = NP_005032
| Hs_RefseqmRNA = NM_005041
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 72027110
| Hs_GenLoc_end = 72032521
| Hs_Uniprot = P14222
| Mm_EntrezGene = 18646
| Mm_Ensembl = ENSMUSG00000037202
| Mm_RefseqmRNA = NM_011073
| Mm_RefseqProtein = NP_035203
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 60693191
| Mm_GenLoc_end = 60699667
| Mm_Uniprot = P10820
}}
}}
'''Perforin 1 (pore forming protein)''', also known as '''PRF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.<ref>{{cite web | title = Entrez Gene: PRF1 perforin 1 (pore forming protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5551| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Trapani JA |title=Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B. |journal=Australian and New Zealand journal of medicine |volume=25 |issue= 6 |pages= 793-9 |year= 1996 |pmid= 8770355 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMC5... {November 7, 2007 3:14:35 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:15:14 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) 26S subunit, ATPase, 5
| HGNCid = 9552
| Symbol = PSMC5
| AltSymbols =; p45; S8; SUG1; TBP10; TRIP1; p45/SUG
| OMIM = 601681
| ECnumber =
| Homologene = 2098
| MGIid = 105047
| GeneAtlas_image1 = PBB_GE_PSMC5_209503_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0031531 |text = thyrotropin-releasing hormone receptor binding}}
| Component = {{GNF_GO|id=GO:0000502 |text = proteasome complex (sensu Eukaryota)}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0030163 |text = protein catabolic process}} {{GNF_GO|id=GO:0043069 |text = negative regulation of programmed cell death}} {{GNF_GO|id=GO:0043161 |text = proteasomal ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0043193 |text = positive regulation of gene-specific transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5705
| Hs_Ensembl = ENSG00000087191
| Hs_RefseqProtein = NP_002796
| Hs_RefseqmRNA = NM_002805
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 59258519
| Hs_GenLoc_end = 59263098
| Hs_Uniprot = P62195
| Mm_EntrezGene = 19184
| Mm_Ensembl = ENSMUSG00000020708
| Mm_RefseqmRNA = NM_008950
| Mm_RefseqProtein = NP_032976
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 106072244
| Mm_GenLoc_end = 106079207
| Mm_Uniprot = Q99KR1
}}
}}
'''Proteasome (prosome, macropain) 26S subunit, ATPase, 5''', also known as '''PSMC5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha.<ref>{{cite web | title = Entrez Gene: PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5705| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTHR1... {November 7, 2007 3:15:14 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:15:51 PM PST}
- CREATED: Created new protein page: PTHR1 {November 7, 2007 3:15:58 PM PST}
- INFO: Beginning work on PTMA... {November 7, 2007 3:15:58 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:16:14 PM PST}
- CREATED: Created new protein page: PTMA {November 7, 2007 3:16:20 PM PST}
- INFO: Beginning work on PTN... {November 7, 2007 3:16:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:17:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
| HGNCid = 9630
| Symbol = PTN
| AltSymbols =; HARP; HBGF8; HBNF; NEGF1
| OMIM = 162095
| ECnumber =
| Homologene = 2117
| MGIid = 97804
| GeneAtlas_image1 = PBB_GE_PTN_209465_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTN_209466_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PTN_211737_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004864 |text = protein phosphatase inhibitor activity}} {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0007185 |text = transmembrane receptor protein tyrosine phosphatase signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007612 |text = learning}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0030282 |text = bone mineralization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5764
| Hs_Ensembl = ENSG00000105894
| Hs_RefseqProtein = NP_002816
| Hs_RefseqmRNA = NM_002825
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 136562637
| Hs_GenLoc_end = 136679086
| Hs_Uniprot = P21246
| Mm_EntrezGene = 19242
| Mm_Ensembl = ENSMUSG00000029838
| Mm_RefseqmRNA = NM_008973
| Mm_RefseqProtein = NP_032999
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 36645087
| Mm_GenLoc_end = 36741513
| Mm_Uniprot = Q3TSS2
}}
}}
'''Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)''', also known as '''PTN''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAD50... {November 7, 2007 3:24:50 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:25:55 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = RAD50 homolog (S. cerevisiae)
| HGNCid = 9816
| Symbol = RAD50
| AltSymbols =; RAD50-2; hRad50
| OMIM = 604040
| ECnumber =
| Homologene = 38092
| MGIid = 109292
| GeneAtlas_image1 = PBB_GE_RAD50_208393_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAD50_209349_at_tn.png
| Function = {{GNF_GO|id=GO:0000014 |text = single-stranded DNA specific endodeoxyribonuclease activity}} {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004518 |text = nuclease activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008408 |text = 3'-5' exonuclease activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000781 |text = chromosome, telomeric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}} {{GNF_GO|id=GO:0030870 |text = Mre11 complex}}
| Process = {{GNF_GO|id=GO:0000019 |text = regulation of mitotic recombination}} {{GNF_GO|id=GO:0006302 |text = double-strand break repair}} {{GNF_GO|id=GO:0007004 |text = telomere maintenance via telomerase}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007126 |text = meiosis}} {{GNF_GO|id=GO:0007131 |text = meiotic recombination}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10111
| Hs_Ensembl = ENSG00000113522
| Hs_RefseqProtein = NP_005723
| Hs_RefseqmRNA = NM_005732
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 131920529
| Hs_GenLoc_end = 132007651
| Hs_Uniprot = Q92878
| Mm_EntrezGene = 19360
| Mm_Ensembl = ENSMUSG00000020380
| Mm_RefseqmRNA = NM_009012
| Mm_RefseqProtein = NP_033038
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 53492942
| Mm_GenLoc_end = 53550742
| Mm_Uniprot = Q3UNL2
}}
}}
'''RAD50 homolog (S. cerevisiae)''', also known as '''RAD50''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.<ref>{{cite web | title = Entrez Gene: RAD50 RAD50 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10111| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Stracker TH, Theunissen JW, Morales M, Petrini JH |title=The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. |journal=DNA Repair (Amst.) |volume=3 |issue= 8-9 |pages= 845-54 |year= 2005 |pmid= 15279769 |doi= 10.1016/j.dnarep.2004.03.014 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RBBP4... {November 7, 2007 3:17:56 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:18:10 PM PST}
- CREATED: Created new protein page: RBBP4 {November 7, 2007 3:18:18 PM PST}
- INFO: Beginning work on SCNN1B... {November 7, 2007 3:18:18 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:18:53 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Sodium channel, nonvoltage-gated 1, beta (Liddle syndrome)
| HGNCid = 10600
| Symbol = SCNN1B
| AltSymbols =; ENaCb; ENaCbeta; SCNEB
| OMIM = 600760
| ECnumber =
| Homologene = 284
| MGIid = 104696
| GeneAtlas_image1 = PBB_GE_SCNN1B_205464_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015280 |text = amiloride-sensitive sodium channel activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0007588 |text = excretion}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6338
| Hs_Ensembl = ENSG00000168447
| Hs_RefseqProtein = NP_000327
| Hs_RefseqmRNA = NM_000336
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 23221133
| Hs_GenLoc_end = 23300120
| Hs_Uniprot = P51168
| Mm_EntrezGene = 20277
| Mm_Ensembl = ENSMUSG00000030873
| Mm_RefseqmRNA = NM_011325
| Mm_RefseqProtein = NP_035455
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 121656228
| Mm_GenLoc_end = 121709876
| Mm_Uniprot = Q3TP51
}}
}}
'''Sodium channel, nonvoltage-gated 1, beta (Liddle syndrome)''', also known as '''SCNN1B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Alvarez de la Rosa D, Canessa CM, Fyfe GK, Zhang P |title=Structure and regulation of amiloride-sensitive sodium channels. |journal=Annu. Rev. Physiol. |volume=62 |issue= |pages= 573-94 |year= 2000 |pmid= 10845103 |doi= 10.1146/annurev.physiol.62.1.573 }}
*{{cite journal | author=Rossier BC, Pradervand S, Schild L, Hummler E |title=Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors. |journal=Annu. Rev. Physiol. |volume=64 |issue= |pages= 877-97 |year= 2002 |pmid= 11826291 |doi= 10.1146/annurev.physiol.64.082101.143243 }}
*{{cite journal | author=Peters KW, Qi J, Johnson JP, ''et al.'' |title=Role of snare proteins in CFTR and ENaC trafficking. |journal=Pflugers Arch. |volume=443 Suppl 1 |issue= |pages= S65-9 |year= 2002 |pmid= 11845306 |doi= 10.1007/s004240100647 }}
*{{cite journal | author=Edelheit O, Hanukoglu I, Gizewska M, ''et al.'' |title=Novel mutations in epithelial sodium channel (ENaC) subunit genes and phenotypic expression of multisystem pseudohypoaldosteronism. |journal=Clin. Endocrinol. (Oxf) |volume=62 |issue= 5 |pages= 547-53 |year= 2005 |pmid= 15853823 |doi= 10.1111/j.1365-2265.2005.02255.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SFTPB... {November 7, 2007 3:18:53 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:19:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Surfactant, pulmonary-associated protein B
| HGNCid = 10801
| Symbol = SFTPB
| AltSymbols =; PSP-B; SFTB3; SFTP3; SP-B
| OMIM = 178640
| ECnumber =
| Homologene = 456
| MGIid = 109516
| GeneAtlas_image1 = PBB_GE_SFTPB_213936_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_SFTPB_214354_x_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005764 |text = lysosome}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006665 |text = sphingolipid metabolic process}} {{GNF_GO|id=GO:0007585 |text = respiratory gaseous exchange}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0050828 |text = regulation of liquid surface tension}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6439
| Hs_Ensembl = ENSG00000168878
| Hs_RefseqProtein = NP_000533
| Hs_RefseqmRNA = NM_000542
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 85737954
| Hs_GenLoc_end = 85748823
| Hs_Uniprot = P07988
| Mm_EntrezGene = 20388
| Mm_Ensembl = ENSMUSG00000056370
| Mm_RefseqmRNA = XM_974249
| Mm_RefseqProtein = XP_979343
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 72234134
| Mm_GenLoc_end = 72242441
| Mm_Uniprot = Q2M2M2
}}
}}
'''Surfactant, pulmonary-associated protein B''', also known as '''SFTPB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Pérez-Gil J |title=Lipid-protein interactions of hydrophobic proteins SP-B and SP-C in lung surfactant assembly and dynamics. |journal=Pediatric pathology & molecular medicine |volume=20 |issue= 6 |pages= 445-69 |year= 2002 |pmid= 11699574 |doi= }}
*{{cite journal | author=Johansson J, Curstedt T, Robertson B |title=Artificial surfactants based on analogues of SP-B and SP-C. |journal=Pediatric pathology & molecular medicine |volume=20 |issue= 6 |pages= 501-18 |year= 2002 |pmid= 11699576 |doi= }}
*{{cite journal | author=Nogee LM |title=Alterations in SP-B and SP-C expression in neonatal lung disease. |journal=Annu. Rev. Physiol. |volume=66 |issue= |pages= 601-23 |year= 2004 |pmid= 14977415 |doi= 10.1146/annurev.physiol.66.032102.134711 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SHBG... {November 7, 2007 3:19:48 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SHBG image.jpg {November 7, 2007 3:20:22 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:20:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SHBG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d2s.
| PDB = {{PDB2|1d2s}}, {{PDB2|1f5f}}, {{PDB2|1kdk}}, {{PDB2|1kdm}}, {{PDB2|1lhn}}, {{PDB2|1lho}}, {{PDB2|1lhu}}, {{PDB2|1lhv}}, {{PDB2|1lhw}}
| Name = Sex hormone-binding globulin
| HGNCid = 10839
| Symbol = SHBG
| AltSymbols =; ABP; MGC126834; MGC138391
| OMIM = 182205
| ECnumber =
| Homologene = 813
| MGIid = 98295
| GeneAtlas_image1 = PBB_GE_SHBG_215689_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005497 |text = androgen binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0009914 |text = hormone transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6462
| Hs_Ensembl = ENSG00000129214
| Hs_RefseqProtein = NP_001031
| Hs_RefseqmRNA = NM_001040
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 7472099
| Hs_GenLoc_end = 7477426
| Hs_Uniprot = P04278
| Mm_EntrezGene = 20415
| Mm_Ensembl = ENSMUSG00000005202
| Mm_RefseqmRNA = XM_001006589
| Mm_RefseqProtein = XP_001006589
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 69431028
| Mm_GenLoc_end = 69434100
| Mm_Uniprot = Q5F214
}}
}}
'''Sex hormone-binding globulin''', also known as '''SHBG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hammond GL, Bocchinfuso WP |title=Sex hormone-binding globulin: gene organization and structure/function analyses. |journal=Horm. Res. |volume=45 |issue= 3-5 |pages= 197-201 |year= 1996 |pmid= 8964583 |doi= }}
*{{cite journal | author=Rosner W, Hryb DJ, Khan MS, ''et al.'' |title=Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane. |journal=J. Steroid Biochem. Mol. Biol. |volume=69 |issue= 1-6 |pages= 481-5 |year= 1999 |pmid= 10419028 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TERF1... {November 7, 2007 3:20:36 PM PST}
- UPLOAD: Added new Image to wiki:
{November 7, 2007 3:20:54 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:21:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TERF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ba5.
| PDB = {{PDB2|1ba5}}, {{PDB2|1h6o}}, {{PDB2|1ity}}, {{PDB2|1iv6}}, {{PDB2|1w0t}}
| Name = Telomeric repeat binding factor (NIMA-interacting) 1
| HGNCid = 11728
| Symbol = TERF1
| AltSymbols =; TRF; FLJ41416; PIN2; TRBF1; TRF1; hTRF1-AS; t-TRF1
| OMIM = 600951
| ECnumber =
| Homologene = 7570
| MGIid = 109634
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003691 |text = double-stranded telomeric DNA binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0000781 |text = chromosome, telomeric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0007004 |text = telomere maintenance via telomerase}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7013
| Hs_Ensembl =
| Hs_RefseqProtein = NP_003209
| Hs_RefseqmRNA = NM_003218
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 21749
| Mm_Ensembl = ENSMUSG00000025925
| Mm_RefseqmRNA = NM_009352
| Mm_RefseqProtein = NP_033378
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 15790872
| Mm_GenLoc_end = 15828645
| Mm_Uniprot = Q7TSK8
}}
}}
'''Telomeric repeat binding factor (NIMA-interacting) 1''', also known as '''TERF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products.<ref>{{cite web | title = Entrez Gene: TERF1 telomeric repeat binding factor (NIMA-interacting) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7013| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TFF1... {November 7, 2007 3:21:16 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TFF1 image.jpg {November 7, 2007 3:21:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:22:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TFF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hi7.
| PDB = {{PDB2|1hi7}}, {{PDB2|1ps2}}
| Name = Trefoil factor 1
| HGNCid = 11755
| Symbol = TFF1
| AltSymbols =; BCEI; D21S21; HP1.A; HPS2; pNR-2; pS2
| OMIM = 113710
| ECnumber =
| Homologene = 2426
| MGIid = 88135
| GeneAtlas_image1 = PBB_GE_TFF1_205009_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component =
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7031
| Hs_Ensembl = ENSG00000160182
| Hs_RefseqProtein = NP_003216
| Hs_RefseqmRNA = NM_003225
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 42655462
| Hs_GenLoc_end = 42659713
| Hs_Uniprot = P04155
| Mm_EntrezGene = 21784
| Mm_Ensembl = ENSMUSG00000024032
| Mm_RefseqmRNA = NM_009362
| Mm_RefseqProtein = NP_033388
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 30872609
| Mm_GenLoc_end = 30892065
| Mm_Uniprot = Q149Y8
}}
}}
'''Trefoil factor 1''', also known as '''TFF1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.<ref>{{cite web | title = Entrez Gene: TFF1 trefoil factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7031| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Langer G, Jagla W, Behrens-Baumann W, ''et al.'' |title=Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells. |journal=Adv. Exp. Med. Biol. |volume=506 |issue= Pt A |pages= 313-6 |year= 2003 |pmid= 12613926 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TGFB3... {November 7, 2007 3:22:11 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TGFB3 image.jpg {November 7, 2007 3:22:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 3:22:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TGFB3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ktz.
| PDB = {{PDB2|1ktz}}, {{PDB2|1tgj}}, {{PDB2|1tgk}}
| Name = Transforming growth factor, beta 3
| HGNCid = 11769
| Symbol = TGFB3
| AltSymbols =; ARVD; FLJ16571; TGF-beta3
| OMIM = 190230
| ECnumber =
| Homologene = 2433
| MGIid = 98727
| GeneAtlas_image1 = PBB_GE_TGFB3_209747_at_tn.png
| Function = {{GNF_GO|id=GO:0005160 |text = transforming growth factor beta receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component =
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009790 |text = embryonic development}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0016049 |text = cell growth}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7043
| Hs_Ensembl = ENSG00000119699
| Hs_RefseqProtein = NP_003230
| Hs_RefseqmRNA = NM_003239
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 75494195
| Hs_GenLoc_end = 75517242
| Hs_Uniprot = P10600
| Mm_EntrezGene = 21809
| Mm_Ensembl = ENSMUSG00000021253
| Mm_RefseqmRNA = XM_994378
| Mm_RefseqProtein = XP_999472
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 86945904
| Mm_GenLoc_end = 86968101
| Mm_Uniprot = Q3TRQ9
}}
}}
'''Transforming growth factor, beta 3''', also known as '''TGFB3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kalluri R, Neilson EG |title=Epithelial-mesenchymal transition and its implications for fibrosis. |journal=J. Clin. Invest. |volume=112 |issue= 12 |pages= 1776-84 |year= 2004 |pmid= 14679171 |doi= 10.1172/JCI200320530 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRAF1... {November 7, 2007 3:22:58 PM PST}
- CREATE: Found no pages, creating new page. {November 7, 2007 3:23:40 PM PST}
- CREATED: Created new protein page: TRAF1 {November 7, 2007 3:23:47 PM PST}
end log.
