CYP51A1
| Cytochrome P450, Family 51, Subfamily A, Polypeptide 1 | |
|---|---|
| 識別 | |
| 符號 | CYP51A1 |
| 替換符號 | CYP51, P45014DM |
| Entrez | 1595 |
| HUGO | 2649 |
| OMIM | 601637 |
| RefSeq | NM_000786 |
| UniProt | Q16850 |
| 其他資料 | |
| EC編號 | 1.14.14.154 |
| 基因座 | 7 q21.2-21.3 |
細胞色素 P450 51A1（英語：Cytochrome P450 27A1，縮寫CYP51A1）也被稱為羊毛甾醇-14α-脫甲基酶（Lanosterol 14α-demethylase，EC 1.14.14.154），是細胞色素P450超家族的一員，在人類基因組中由CYP51A1基因編碼，可催化帶有14α甲基的甾醇（如羊毛甾醇）去甲基化並D環上的C14-C15脫氫生成對應的甾醇（如4,4-二甲基膽甾-8(9),14,24-三烯-3β-醇）[6]。在後鞭毛生物（包括動物和真菌）的膽固醇合成中，CYP51A1催化2,3-環氧鯊烯成環後的第一步反應，是參與甾體生成的第一個CYP酶[7]。
進化
[編輯]CYP51A1所屬的CYP51家族是進化上較保守的家族[8]，在功能上都催化對應甾醇的14α脫甲基化[9]，在真核域和細菌域中都廣泛存在，但不同生物界之間CYP51的相似性只有22-30%[10]。
參考文獻
[編輯]- ^ 對cytochrome P450 family 51 subfamily A member 1起作用的藥物；在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000001630 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000001467 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Metabocard for 4,4-Dimethylcholesta-8,14,24-trienol (HMDB01023). Human Metabolome Database. February 2014 [2020-04-18]. （原始內容存檔於2017-12-26）.
- ^ Lepesheva GI, Waterman MR. Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms. Biochimica et Biophysica Acta. March 2007, 1770 (3): 467–77. PMC 2324071
. PMID 16963187. doi:10.1016/j.bbagen.2006.07.018.
- ^ Lepesheva GI, Waterman MR. CYP51--the omnipotent P450. Molecular and Cellular Endocrinology. February 2004, 215 (1–2): 165–70. PMID 15026190. doi:10.1016/j.mce.2003.11.016.
- ^ Becher R, Wirsel SG. Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens. Applied Microbiology and Biotechnology. August 2012, 95 (4): 825–40. PMID 22684327. doi:10.1007/s00253-012-4195-9.
- ^ Lepesheva GI, Waterman MR. Structural basis for conservation in the CYP51 family. Biochimica et Biophysica Acta. January 2011, 1814 (1): 88–93. PMC 2962772 . PMID 20547249. doi:10.1016/j.bbapap.2010.06.006.